Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic Cancer

CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma

(2021) Deepak Raj et al.   CLINICAL CANCER RESEARCH

Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption

(2021) Sophie D. Adams et al.   CURRENT BIOLOGY

Myc instructs and maintains pancreatic adenocarcinoma phenotype

(2020) Nicole M Sodir et al.   Cancer Discovery

High‐grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF‐1

(2020) Anne Steins et al.   EMBO REPORTS

Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer

(2020) Sohinee Bhattacharyya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness

(2020) Mei-Yu Quan et al.   Frontiers in Cell and Developmental Biology

Infigratinib in patients with advanced cholangiocarcinoma with FGFR2 gene fusions/translocations: the PROOF 301 trial

(2020) Shalini Makawita et al.   Future Oncology

Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer

(2020) Hemant M. Kocher et al.   Nature Communications

FGF2 Inhibits Early Pancreatic Lineage Specification during Differentiation of Human Embryonic Stem Cells

(2020) Rabea Dettmer et al.   Cells

Experimental microdissection enables functional harmonisation of pancreatic cancer subtypes

(2019) Hans Carlo Maurer et al.   GUT

CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer

(2019) Letizia Porcelli et al.   Cancers

Deciphering role of FGFR signalling pathway in pancreatic cancer

(2019) Xiaodiao Kang et al.   CELL PROLIFERATION

E-cadherin is required for metastasis in multiple models of breast cancer

(2019) Veena Padmanaban et al.   NATURE

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The therapeutic targeting of the FGFR1/Src/NF-κB signaling axis inhibits pancreatic ductal adenocarcinoma stemness and oncogenicity

(2018) Shiue-Wei Lai et al.   CLINICAL & EXPERIMENTAL METASTASIS

An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers

(2018) Mélanie Mahe et al.   EMBO Molecular Medicine

Targeting glypican-4 overcomes 5-FU resistance and attenuates stem cell-like properties via suppression of Wnt/β-catenin pathway in pancreatic cancer cells

(2018) Junyu Cao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Ever-Evolving Concept of the Cancer Stem Cell in Pancreatic Cancer

(2018) Sandra Valle et al.   Cancers

Variable Effects of Growth Factors on Developmental Gene Expression in Pancreatic Cancer Cells

(2018) D. A. Gnatenko et al.   Doklady Biochemistry and Biophysics

A Phase Ib Study of the FGFR/VEGFR Inhibitor Dovitinib With Gemcitabine and Capecitabine in Advanced Solid Tumor and Pancreatic Cancer Patients

(2018) Wen Wee Ma et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment

(2018) Ernesto Cortes et al.   EMBO REPORTS

Inter- and intra-tumoral heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma

(2018) Cindy Neuzillet et al.   JOURNAL OF PATHOLOGY

A potential novel therapy for FGFR1‑amplified pancreatic cancer with bone metastasis, screened by next‑generation sequencing and a patient‑derived xenograft model

(2018) Zhonghai Guan et al.   Oncology Letters

Cotargeting of MEK and PDGFR/STAT3 Pathways to Treat Pancreatic Ductal Adenocarcinoma

(2017) Nisebita Sahu et al.   MOLECULAR CANCER THERAPEUTICS

SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer

(2017) H Zhou et al.   ONCOGENE

Unravelling the pharmacologic opportunities and future directions for targeted therapies in gastro-intestinal cancers Part 1: GI carcinomas

(2017) Cindy Neuzillet et al.   PHARMACOLOGY & THERAPEUTICS

The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance

(2017) Sunjida Ahmed et al.   Journal of Clinical Medicine

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation

(2016) Christopher J. Tape et al.   CELL

Echoes of the embryo: using the developmental biology toolkit to study cancer

(2016) Nicole M. Aiello et al.   Disease Models & Mechanisms

Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression

(2016) Pei‐Yu Chen et al.   EMBO Molecular Medicine

Pancreatic stellate cells regulate blood vessel density in the stroma of pancreatic ductal adenocarcinoma

(2016) Francesco Di Maggio et al.   PANCREATOLOGY

Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells

(2016) Michael Friberg Bruun Nielsen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

(2016) Antonios Chronopoulos et al.   Nature Communications

Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGFβ)-dependent smooth muscle cell phenotype modulation

(2016) Pei-Yu Chen et al.   Scientific Reports

Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer

(2015) Niranjan Awasthi et al.   CANCER LETTERS

Nintedanib Is a Highly Effective Therapeutic for Neuroendocrine Carcinoma of the Pancreas (PNET) in the Rip1Tag2 Transgenic Mouse Model

(2015) R. Bill et al.   CLINICAL CANCER RESEARCH

Homeostatic Restoration of Desmoplastic Stroma Rather Than Its Ablation Slows Pancreatic Cancer Progression

(2015) Fieke E.M. Froeling et al.   GASTROENTEROLOGY

Clinicopathological significance of fibroblast growth factor 1 in non–small cell lung cancer

(2015) Juan Li et al.   HUMAN PATHOLOGY

Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction

(2015) Edward P. Carter et al.   TRENDS IN CELL BIOLOGY

Pancreatic Adenocarcinoma

(2015) David P. Ryan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Inhibition of fibroblast growth factor receptor 2 attenuates proliferation and invasion of pancreatic cancer

(2014) Yoko Matsuda et al.   CANCER SCIENCE

Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion

(2014) S. J. Coleman et al.   EMBO Molecular Medicine

Serum Cytokine Profile in Patients With Pancreatic Cancer

(2014) Carolina Torres et al.   PANCREAS

The Tumor Suppressor Smad4/DPC4 Is Regulated by Phosphorylations that Integrate FGF, Wnt, and TGF-β Signaling

(2014) Hadrien Demagny et al.   Cell Reports

The desmoplastic stroma of pancreatic cancer is a barrier to immune cell infiltration

(2014) Jennifer Watt et al.   OncoImmunology

Cancer mortality in Europe, 2005–2009, and an overview of trends since 1980

(2013) C. Bosetti et al.   ANNALS OF ONCOLOGY

Enhanced FGFR signalling predisposes pancreatic cancer to the effect of a potent FGFR inhibitor in preclinical models

(2013) H Zhang et al.   BRITISH JOURNAL OF CANCER

Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling

(2013) Corentin Herbert et al.   CANCER CELL

Inhibition of Tumor Angiogenesis and Growth by a Small-Molecule Multi-FGF Receptor Blocker with Allosteric Properties

(2013) Françoise Bono et al.   CANCER CELL

Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma

(2013) Abasi Ene–Obong et al.   GASTROENTEROLOGY

Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes

(2013) Raghu Kadaba et al.   JOURNAL OF PATHOLOGY

BIBF 1120 (Nintedanib), a Triple Angiokinase Inhibitor, Induces Hypoxia but not EMT and Blocks Progression of Preclinical Models of Lung and Pancreatic Cancer

(2013) B. Kutluk Cenik et al.   MOLECULAR CANCER THERAPEUTICS

Enhanced Expression of Fibroblast Growth Factor Receptor 2 IIIc Promotes Human Pancreatic Cancer Cell Proliferation

(2012) Toshiyuki Ishiwata et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

Regulation of pancreatic function by connective tissue growth factor (CTGF, CCN2)

(2012) Alyssa Charrier et al.   CYTOKINE & GROWTH FACTOR REVIEWS

A Sox9/Fgf feed-forward loop maintains pancreatic organ identity

(2012) P. A. Seymour et al.   DEVELOPMENT

Ponatinib (AP24534), a Multitargeted Pan-FGFR Inhibitor with Activity in Multiple FGFR-Amplified or Mutated Cancer Models

(2012) J. M. Gozgit et al.   MOLECULAR CANCER THERAPEUTICS

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Retinoic Acid–Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt–β-Catenin Signaling to Slow Tumor Progression

(2011) Fieke E.M. Froeling et al.   GASTROENTEROLOGY

SOX9 controls epithelial branching by activating RET effector genes during kidney development

(2011) Antoine Reginensi et al.   HUMAN MOLECULAR GENETICS

Targeting FGFR/PDGFR/VEGFR Impairs Tumor Growth, Angiogenesis, and Metastasis by Effects on Tumor Cells, Endothelial Cells, and Pericytes in Pancreatic Cancer

(2011) J. Taeger et al.   MOLECULAR CANCER THERAPEUTICS

Analysis of the Human Pancreatic Stellate Cell Secreted Proteome

(2011) Angela Y. Wehr et al.   PANCREAS

FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis

(2011) L. A. Naiche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of Stellate Cells with Pancreatic Carcinoma Cells

(2010) Hansjörg Habisch et al.   Cancers

Inhibition of endogenous SPARC enhances pancreatic cancer cell growth: modulation by FGFR1-III isoform expression

(2009) G Chen et al.   BRITISH JOURNAL OF CANCER

Pancreatic Endocrine Tumors: Expression Profiling Evidences a Role for AKT-mTOR Pathway

(2009) Edoardo Missiaglia et al.   JOURNAL OF CLINICAL ONCOLOGY

Cadherin-Bound β-Catenin Feeds into the Wnt Pathway upon Adherens Junctions Dissociation: Evidence for an Intersection between β-Catenin Pools

(2009) Yoonseok Kam et al.   PLoS One

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

FGF10/FGFR2 signal induces cell migration and invasion in pancreatic cancer

(2008) S Nomura et al.   BRITISH JOURNAL OF CANCER

Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development

(2008) D. ten Berge et al.   DEVELOPMENT

An FGF–WNT gene regulatory network controls lung mesenchyme development

(2008) Yongjun Yin et al.   DEVELOPMENTAL BIOLOGY

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer

(2008) G. Feldmann et al.   MOLECULAR CANCER THERAPEUTICS

Analysis of mortality rates for pancreatic cancer across the world

(2008) D. Hariharan et al.   HPB