Targeting CX3CR1 Suppresses the Fanconi Anemia DNA Repair Pathway and Synergizes with Platinum

Fractalkine/CX3CL1 in Neoplastic Processes

(2020) Jan Korbecki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fanconi anemia pathway as a prospective target for cancer intervention

(2020) Wenjun Liu et al.   Cell and Bioscience

Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

(2020) Winnie Tan et al.   eLife

The identification of the ATR inhibitor VE-822 as a therapeutic strategy for enhancing cisplatin chemosensitivity in esophageal squamous cell carcinoma

(2018) Qi Shi et al.   CANCER LETTERS

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

Regulation of DNA damage repair and lipid uptake by CX3CR1 in epithelial ovarian carcinoma

(2018) Jia Xie et al.   Oncogenesis

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

(2018) Nina M. S. Gustafsson et al.   Nature Communications

ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links

(2018) Karun Mutreja et al.   Cell Reports

DNA repair pathways and cisplatin resistance: an intimate relationship

(2018) CR Rocha et al.   Clinics

FANCD2 limits replication stress and genome instability in cells lacking BRCA2

(2016) Johanna Michl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5′-DNA end

(2016) Koichi Sato et al.   NUCLEIC ACIDS RESEARCH

The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2

(2016) Chih-Chao Liang et al.   Nature Communications

The functional status of DNA repair pathways determines the sensitization effect to cisplatin in non-small cell lung cancer cells

(2016) Ping Chen et al.   CELLULAR ONCOLOGY

FANCD2 limits replication stress and genome instability in cells lacking BRCA2

(2016) Johanna Michl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CX3CL1/CX3CR1 in Alzheimer’s Disease: A Target for Neuroprotection

(2016) Peiqing Chen et al.   Biomed Research International

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

(2015) Guotai Xu et al.   NATURE

FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2

(2015) Maria Castella et al.   PLoS Genetics

DNA Damage Checkpoint Responses in the S Phase of Synchronized Diploid Human Fibroblasts

(2014) Paul D. Chastain et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Substituted 7-Amino-5-thio-thiazolo[4,5-d]pyrimidines as Potent and Selective Antagonists of the Fractalkine Receptor (CX3CR1)

(2013) Sofia Karlström et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition

(2011) Komaraiah Palle et al.   CELL CYCLE

Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M

(2009) T. R. Singh et al.   BLOOD

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

(2009) Renee D. Paulsen et al.   MOLECULAR CELL

The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

(2009) P. Knipscheer et al.   SCIENCE