Multiregional Sequencing of IDH-WT Glioblastoma Reveals High Genetic Heterogeneity and a Dynamic Evolutionary History

Hippo Signaling Pathway in Gliomas

(2021) Konstantin Masliantsev et al.   Cells

From cells to tissue: How cell scale heterogeneity impacts glioblastoma growth and treatment response

(2020) Jill A. Gallaher et al.   PLoS Computational Biology

CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications

(2020) Sebastià Franch-Expósito et al.   eLife

Phylogenetic Tree Inference: A Top-Down Approach to Track Tumor Evolution

(2020) Pin Wu et al.   Frontiers in Genetics

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Longer-term (≥ 2 years) survival in patients with glioblastoma in population-based studies pre- and post-2005: a systematic review and meta-analysis

(2020) Michael T. C. Poon et al.   Scientific Reports

Fusions involving BCOR and CREBBP are rare events in infiltrating glioma

(2020) David J. Pisapia et al.   Acta Neuropathologica Communications

Genomic profiling of newly diagnosed glioblastoma patients and its potential for clinical utility – a prospective, translational study

(2020) Dorte S. Nørøxe et al.   Molecular Oncology

Predicting Survival in Glioblastoma Patients Using Diffusion MR Imaging Metrics—A Systematic Review

(2020) Valentina Brancato et al.   Cancers

ELAVL1 Role in Cell Fusion and Tunneling Membrane Nanotube Formations with Implication to Treat Glioma Heterogeneity

(2020) Natalia Filippova et al.   Cancers

Current Opinion on Molecular Characterization for GBM Classification in Guiding Clinical Diagnosis, Prognosis, and Therapy

(2020) Pei Zhang et al.   Frontiers in Molecular Biosciences

Role of Notch Signaling Pathway in Glioblastoma Multiforme Pathogenesis

(2019) Riccardo Bazzoni et al.   Cancers

Comparison of Biomarker Assays for EGFR: Implications for Precision Medicine in Patients with Glioblastoma

(2019) Andrew B. Lassman et al.   CLINICAL CANCER RESEARCH

Whole exome sequencing reveals mutations in FAT1 tumor suppressor gene clinically impacting on peripheral T-cell lymphoma not otherwise specified

(2019) Maria Antonella Laginestra et al.   MODERN PATHOLOGY

Prognostic implications of a molecular classifier derived from whole‐exome sequencing in nasopharyngeal carcinoma

(2019) Hai‐Yun Wang et al.   Cancer Medicine

MET in glioma: signaling pathways and targeted therapies

(2019) Fangling Cheng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Therapeutic Targeting of the Notch Pathway in Glioblastoma

(2019) Zachary Gersey et al.   World Neurosurgery

Total copy number variation as a prognostic factor in adult astrocytoma subtypes

(2019) Kanish Mirchia et al.   Acta Neuropathologica Communications

Laser Capture Microdissection and RNA-Seq Analysis: High Sensitivity Approaches to Explain Histopathological Heterogeneity in Human Glioblastoma FFPE Archived Tissues

(2019) Prospero Civita et al.   Frontiers in Oncology

Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma

(2019) Stefanie N. Meyer et al.   IMMUNITY

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

(2019) Fadi Jacob et al.   CELL

A human co‐culture cell model incorporating microglia supports glioblastoma growth and migration, and confers resistance to cytotoxics

(2019) Diana M. Leite et al.   FASEB JOURNAL

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

Cancer astrocytes have a more conserved molecular status in long recurrence free survival (RFS) IDH1 wild-type glioblastoma patients: new emerging cancer players

(2018) Sara Franceschi et al.   Oncotarget

Evolutionary dynamics of residual disease in human glioblastoma

(2018) I Spiteri et al.   ANNALS OF ONCOLOGY

VarSome: the human genomic variant search engine

(2018) Christos Kopanos et al.   BIOINFORMATICS

European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas

(2017) Michael Weller et al.   LANCET ONCOLOGY

Spatiotemporal genomic architecture informs precision oncology in glioblastoma

(2017) Jin-Ku Lee et al.   NATURE GENETICS

Biological and therapeutic implications of multisector sequencing in newly diagnosed glioblastoma

(2017) Tatenda Mahlokozera et al.   NEURO-ONCOLOGY

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Inhibition of the PI3K/AKT/mTOR Pathway in Solid Tumors

(2016) Patricia Mucci LoRusso   JOURNAL OF CLINICAL ONCOLOGY

Expression and significance of Hippo/YAP signaling in glioma progression

(2016) Hao Zhang et al.   TUMOR BIOLOGY

PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma

(2016) Xiaoman Li et al.   Oncotarget

An expression based REST signature predicts patient survival and therapeutic response for glioblastoma multiforme

(2016) Jianfeng Liang et al.   Scientific Reports

CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing

(2016) Eric Talevich et al.   PLoS Computational Biology

Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma

(2016) Nicole R. Parker et al.   Scientific Reports

Spatiotemporal Evolution of the Primary Glioblastoma Genome

(2015) Jinkuk Kim et al.   CANCER CELL

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

(2015) Sue Richards et al.   GENETICS IN MEDICINE

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

(2015) Hoon Kim et al.   GENOME RESEARCH

TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data

(2015) Antonio Colaprico et al.   NUCLEIC ACIDS RESEARCH

DNA copy number analysis of Grade II–III and Grade IV gliomas reveals differences in molecular ontogeny including chromothripsis associated with IDH mutation status

(2015) Adam Cohen et al.   Acta Neuropathologica Communications

Epidemiologic and Molecular Prognostic Review of Glioblastoma

(2014) J. P. Thakkar et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

(2014) Gang Wu et al.   NATURE GENETICS

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival

(2013) S. Zheng et al.   GENES & DEVELOPMENT

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation

(2013) Luc G T Morris et al.   NATURE GENETICS

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

(2013) A. Sottoriva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells

(2012) Owen D. Stechishin et al.   NEURO-ONCOLOGY

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells

(2012) B Dikshit et al.   ONCOGENE

Heterogeneity Maintenance in Glioblastoma: A Social Network

(2011) R. Bonavia et al.   CANCER RESEARCH

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Migratory neighbors and distant invaders: tumor-associated niche cells

(2008) J. Wels et al.   GENES & DEVELOPMENT

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE