Article
Multidisciplinary Sciences
Joseph G. Kern, Andrew M. Tilston-Lunel, Anthony Federico, Boting Ning, Amy Mueller, Grace B. Peppler, Eleni Stampouloglou, Nan Cheng, Randy L. Johnson, Marc E. Lenburg, Jennifer E. Beane, Stefano Monti, Xaralabos Varelas
Summary: Conditional deletion of LATS1/2 kinases in mature mammary epithelial cells leads to the development of basal-like breast cancer. This study highlights the importance of LATS1/2 kinases in maintaining mammary epithelial cell homeostasis and fate control, and implicates signaling networks induced by the loss of LATS1/2 activity in the development of basal-like breast cancer.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Truc Phan Hoang Le, Nga Thi Thanh Nguyen, Duong Duy Thai Le, Muhammad Ayaz Anwar, Sang Yoon Lee
Summary: In this study, PIP5Ka was found to act as an activator of the Hippo pathway by interacting and colocalizing with Merlin. This interaction promoted PIP2-dependent Merlin activation and induced the local recruitment and activation of LATS1 on the PIP2-rich plasma membrane, resulting in the negative regulation of YAP/TAZ activity.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Youqin Xu, Mu Song, Ziyang Hong, Wancheng Chen, Qianbing Zhang, Jianlong Zhou, Chao Yang, Zilong He, Juanjuan Yu, Xiaolin Peng, Qiuhong Zhu, Shaotian Li, Kaiyuan Ji, Minfeng Liu, Qiang Zuo
Summary: In this study, the regulatory mechanism of breast cancer cell proliferation and metabolism through m6A methylation in the Hippo pathway was explored. It was found that METTL3 acted as the m6A writer, with YTHDF2 as the reader protein of LATS1 mRNA, promoting both tumorigenesis and glycolysis in breast cancer. Knockout of METTL3 or YTHDF2 increased the expression of LATS1 mRNA and suppressed breast cancer tumorigenesis by activating YAP/TAZ in the Hippo pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Boon Chin Heng, Xuehui Zhang, Dominique Aubel, Yunyang Bai, Xiaochan Li, Yan Wei, Martin Fussenegger, Xuliang Deng
Summary: YAP and TAZ are crucial proteins involved in maintaining tissue/organ size and have diverse roles in various biological processes, including cell proliferation, tissue regeneration, cell fate determination, tumorigenesis, and mechanosensing.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Oncology
Tao Luo, Kaikai Ding, Jianxiong Ji, Xin Zhang, Xiaobing Yang, Anjing Chen, Bin Huang, Di Zhang, Jian Wang, Xingang Li
Summary: The study suggests that CKAP4 is highly upregulated in glioma, and high expression of CKAP4 is associated with poor patient survival. CKAP4 promotes malignant progression of gliomas by inhibiting Hippo signaling. Therefore, CKAP4 has the potential to serve as a promising biomarker for predicting patient prognosis and targeting CKAP4 expression may be an effective therapeutic strategy for the treatment of human gliomas.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yi Zhang, Hongwei Xu, Guofei Cui, Binyong Liang, Xiangzheng Chen, Sungjin Ko, Silvia Affo, Xinhua Song, Yi Liao, Jianguo Feng, Pan Wang, Haichuan Wang, Meng Xu, Jingxiao Wang, Giovanni M. Pes, Silvia Ribback, Yong Zeng, Aatur Singhi, Robert F. Schwabe, Satdarshan P. Monga, Matthias Evert, Liling Tang, Diego F. Calvisi, Xin Chen
Summary: YAP induces cholangiocarcinogenesis through TEAD-dependent transcriptional activation and interaction with ss-Catenin. ss-Catenin binds to YAP in iCCA and is required for YAP's full transcriptional activity, revealing the functional crosstalk between YAP and ss-Catenin pathways in cholangiocarcinogenesis.
Review
Cell Biology
Linda Shyue Huey Chuang, Yoshiaki Ito
Summary: The Hippo-YAP signaling pathway plays critical roles in cell functions, interacts with the RUNX transcription factors in proliferation, differentiation, and cell fate determination, and contributes to development and tumorigenesis.
Review
Biochemistry & Molecular Biology
Filippos Koinis, Evangelia Chantzara, Michael Samarinas, Anastasia Xagara, Zisis Kratiras, Vasiliki Leontopoulou, Athanasios Kotsakis
Summary: This article summarizes the role of the Hippo pathway in prostate cancer and identifies knowledge gaps that need to be addressed for the development of YAP-targeted treatment strategies.
Review
Biochemistry & Molecular Biology
Masum M. Mia, Manvendra K. Singh
Summary: This review summarizes recent findings on the involvement of the Hippo signaling pathway in modulating the immune response in different acute and chronic inflammatory diseases, and its impact on tissue repair and remodeling.
Review
Oncology
Carmen Salguero-Aranda, Joaquin Olmedo-Pelayo, Enrique de alava, Ana Teresa Amaral, Juan Diaz-Martin
Summary: Cancer is a genetic disease caused by changes in genes controlling cell growth. The Hippo pathway, a developmental signaling system, plays a critical role in tissue and organ size regulation and is frequently deregulated in cancer. This article reviews the relevance of the Hippo pathway in specific sarcoma subtypes and discusses its genetic alterations and other molecular mechanisms involved in its deregulation. It also explores the potential for targeted therapy in sarcoma based on these alterations.
Review
Oncology
Kelly Coffey
Summary: Prostate cancer is a common cancer in men, and targeting the Hippo pathway for new treatment approaches may help improve the management of this disease.
Article
Biochemistry & Molecular Biology
Dimitrios Matthaios, Maria Tolia, Davide Mauri, Konstantinos Kamposioras, Michalis Karamouzis
Summary: The YAP and Hippo pathway play crucial roles in immune system and cancer, with effects such as modulating immune response, enhancing tumor microenvironment, and regulating immune suppression, suggesting their potential applications in cancer immunotherapy.
Article
Pathology
Jiyoon Jung, Jeong Won Kim, Gilhyang Kim, Joo Young Kim
Summary: In colorectal cancer patients, low expression of MST1/2 and negative expression of LATS1/2 are associated with poor differentiation, large tumor size, and worse overall survival. These findings suggest that MST1/2 and LATS1/2 may serve as prognostic indicators for colorectal cancer patients.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Cell Biology
Xiaolei Zhao, Tram P. Le, Shannon Erhardt, Tina O. Findley, Jun Wang
Summary: Neural crest cells are a migratory stem cell population in vertebrate embryogenesis that play a crucial role in the development of various tissues and organs. Recent studies have highlighted the importance of the Hippo-Yap pathway in normal neural crest development, but further research is needed to fully understand its roles and mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Yu-Ling Chung, Vincent Laiman, Po-Nien Tsao, Chung -Ming Chen, Didik Setyo Heriyanto, Kian Fan Chung, Kai-Jen Chuang, Hsiao-Chi Chuang
Summary: Prenatal exposure to traffic-related air pollution, specifically diesel exhaust particles (DEPs), inhibits lung development in mice fetuses. DEP exposure decreases lung branching morphogenesis and impairs the expression of lung development-related genes. DEPs disrupt the Hippo signaling pathway and induce early cellular senescence in fetal lung fibroblast cells. These findings highlight the adverse effects of air pollution on fetal lung development.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Neurosciences
Mohamad El Amki, Martine Dubois, Antoine Lefevre-Scelles, Nicolas Magne, Melanie Roussel, Thomas Clavier, Pierre-Olivier Guichet, Emmanuel Gerardin, Vincent Compere, Helene Castel
MOLECULAR NEUROBIOLOGY
(2018)
Article
Oncology
Konstantin Masliantsev, Baptiste Pinel, Anais Balbous, Pierre-Olivier Guichet, Gaelle Tachon, Serge Milin, Julie Godet, Mathilde Duchesne, Antoine Berger, Christos Petropoulos, Michel Wager, Lucie Karayan-Tapon
Article
Pathology
Gaelle Tachon, Konstantin Masliantsev, Pierre Rivet, Christos Petropoulos, Julie Godet, Serge Milin, Michel Wager, Pierre-Olivier Guichet, Lucie Karayan-Tapon
Article
Oncology
Elisa Le Boiteux, Franck Court, Pierre-Olivier Guichet, Catherine Vaurs-Barriere, Isabelle Vaillant, Emmanuel Chautard, Pierre Verrelle, Bruno M. Costa, Lucie Karayan-Tapon, Anne Fogli, Philippe Arnaud
Summary: HOX gene deregulation may contribute to the development of adult glioma by leading to widespread upregulation of HOX genes, possibly through escape from DNA hypermethylation at CpG island promoters. The study provides a comprehensive description of epigenetic changes at HOX clusters and their contribution to transcriptional changes observed in adult glioma, as well as identifying potential 'master' HOX proteins that may contribute to the tumorigenic potential of glioma stem cells.
MOLECULAR ONCOLOGY
(2021)
Article
Cell Biology
Vadim Le Joncour, Pierre-Olivier Guichet, Kleouforo-Paul Dembele, Alexandre Mutel, Daniele Campisi, Nicolas Perzo, Laurence Desrues, Romain Modzelewski, Pierre-Olivier Couraud, Jerome Honnorat, Francois-Xavier Ferracci, Florent Marguet, Annie Laquerriere, Pierre Vera, Pierre Bohn, Olivier Langlois, Fabrice Morin, Pierrick Gandolfo, Helene Castel
Summary: The study demonstrated that urotensin II induces aggressive behavior in GBM, leading to necrosis and angiogenesis through integrin activation, which can be targeted by UT biased ligands/antagonists.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Gaelle Tachon, Konstantin Masliantsev, Pierre Rivet, Amandine Desette, Serge Milin, Elise Gueret, Michel Wager, Lucie Karayan-Tapon, Pierre-Olivier Guichet
Summary: The study indicates that high expression of MEOX2 is associated with poor prognosis in glioma, especially for lower grade tumors. MEOX2 expression in GSC depends on the methylation state of its promoter and is strongly correlated with IDH mutations. Additionally, MEOX2 is involved in cell proliferation and viability regulation through the ERK/MAPK and PI3K/AKT pathways.
Article
Biochemistry & Molecular Biology
Marie-Elisa Pinson, Franck Court, Aymeric Masson, Yoan Renaud, Allison Fantini, Ophelie Bacoeur-Ouzillou, Marie Barriere, Bruno Pereira, Pierre-Olivier Guichet, Emmanuel Chautard, Lucie Karayan-Tapon, Pierre Verrelle, Philippe Arnaud, Catherine Vaurs-Barriere
Summary: In addition to the consequences of retrotransposition, L1 retrotransposons affect the host genome through their antisense promoter. The study found widespread expression of LCT in normal brain and glioma samples, with the transcriptional activities of L1 antisense promoters and their host loci being coupled.
HUMAN MOLECULAR GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Elisa Le Boiteux, Pierre-Olivier Guichet, Konstantin Masliantsev, Bertille Montibus, Catherine Vaurs-Barriere, Celine Gonthier-Gueret, Emmanuel Chautard, Pierre Verrelle, Lucie Karayan-Tapon, Anne Fogli, Franck Court, Philippe Arnaud
Summary: The overexpression of long non-coding RNA HOXA-AS2 in Glioma Stem Cells (GSCs) contributes to their aggressiveness by promoting proliferation and modulating the inflammation pathway through the regulation of key transcription factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Konstantin Masliantsev, Margaux Mordrel, Tania Banor, Amandine Desette, Julie Godet, Serge Milin, Michel Wager, Lucie Karayan-Tapon, Pierre-Olivier Guichet
Summary: Gliomas are common and lethal brain tumors, particularly glioblastomas, which pose a therapeutic challenge with poor prognosis. The transcriptional cofactors YAP and TAZ have emerged as crucial factors in malignancy, but their regulation in brain tumors remains unclear. This study investigated the link between EGFR and YAP/TAZ in glioblastomas and found an association between EGFR activation and YAP nuclear location. Pharmacological inhibition of EGFR resulted in increased YAP phosphorylation in PTEN wild-type cultures. These findings suggest the regulation of pS397-YAP by the EGFR-AKT axis in a PTEN-dependent manner, providing new insights into the pathogenesis of glioblastomas.
LABORATORY INVESTIGATION
(2023)
Article
Gastroenterology & Hepatology
Amandine Desette, Pierre-Olivier Guichet, Sheik Emambux, Konstantin Masliantsev, Ulrich Cortes, Birama Ndiaye, Serge Milin, Simon George, Mathieu Faigner, Julie Tisserand, Afsaneh Gaillard, Sebastien Brot, Michel Wager, David Tougeron, Lucie Karayan-Tapon
Summary: This study describes the identification and characterization of cancer stem cells in brain metastasis from colorectal cancer (CRC). These cancer stem cells have self-renewal properties and exhibit invasive and migratory capabilities. Further analysis also identifies a potential candidate gene for identifying high-risk CRC patients.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)