Large Scale Molecular Studies of Pituitary Neuroendocrine Tumors: Novel Markers, Mechanisms and Translational Perspectives

Medication for Acromegaly Reduces Expression of MUC16, MACC1 and GRHL2 in Pituitary Neuroendocrine Tumour Tissue

(2021) Rihards Saksis et al.   Frontiers in Oncology

Case report: recurrent pituitary adenoma has increased load of somatic variants

(2020) Raitis Peculis et al.   BMC Endocrine Disorders

MicroRNAs expression in pituitary tumors: differences related to functional status, pathological features, and clinical behavior

(2020) T. M. Vicchio et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

In silico analysis of the immunological landscape of pituitary adenomas

(2020) Jacky T. Yeung et al.   JOURNAL OF NEURO-ONCOLOGY

Somatic SF3B1 hotspot mutation in prolactinomas

(2020) Chuzhong Li et al.   Nature Communications

Pituispheres Contain Genetic Variants Characteristic to Pituitary Adenoma Tumor Tissue

(2020) Raitis Peculis et al.   Frontiers in Endocrinology

Discovery of novel USP8 inhibitors via Ubiquitin-Rho-110 fluorometric assay based high throughput screening

(2020) Jie Han et al.   BIOORGANIC CHEMISTRY

The tumour microenvironment of pituitary neuroendocrine tumours

(2020) Pedro Marques et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Circulating Plasma microRNA to Differentiate Cushing's Disease From Ectopic ACTH Syndrome

(2020) Zhanna Belaya et al.   Frontiers in Endocrinology

Comprehensive analysis of the immunological landscape of pituitary adenomas: implications of immunotherapy for pituitary adenomas

(2020) Wenjianlong Zhou et al.   JOURNAL OF NEURO-ONCOLOGY

USP8 Inhibitor Suppresses HER-2 Positive Gastric Cancer Cell Proliferation and Metastasis via the PI3K/AKT Signaling Pathway

(2020) Jiangang Sun et al.   OncoTargets and Therapy

miR-16-5p Suppresses Progression and Invasion of Osteosarcoma via Targeting at Smad3

(2020) Zhijian Gu et al.   Frontiers in Pharmacology

Molecular Network Basis of Invasive Pituitary Adenoma: A Review

(2019) Qi Yang et al.   Frontiers in Endocrinology

Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors

(2019) Sayka Barry et al.   ONCOGENE

Comprehensive analysis of circulating microRNAs in plasma of patients with pituitary adenomas

(2019) Kinga Németh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MiR-338-5p promotes metastasis of colorectal cancer by inhibition of phosphatidylinositol 3-kinase, catalytic subunit type 3-mediated autophagy pathway

(2019) Chien-An Chu et al.   EBioMedicine

MicroRNA let-7g acts as tumor suppressor and predictive biomarker for chemoresistance in human epithelial ovarian cancer

(2019) Flavia Biamonte et al.   Scientific Reports

MiR-16-5p inhibits breast cancer by reducing AKT3 to restrain NF-κB pathway

(2019) Liwei Ruan et al.   BIOSCIENCE REPORTS

The Genomic Landscape of Sporadic Prolactinomas

(2019) Sunita M. C. De Sousa et al.   ENDOCRINE PATHOLOGY

Exosome-transmitted lncRNA H19 inhibits the growth of pituitary adenoma

(2019) Yong Zhang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Dopamine agonist resistant prolactinomas: any alternative medical treatment?

(2019) P. Souteiro et al.   Pituitary

Evaluation of the Possibility to Detect Circulating Tumor DNA From Pituitary Adenoma

(2019) Kaspars Megnis et al.   Frontiers in Endocrinology

GENETICS IN ENDOCRINOLOGY: Somatic and germline mutations in the pathogenesis of pituitary adenomas

(2019) Silvia Vandeva et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Upregulation Of miR-149-3p Suppresses Spinal Chordoma Malignancy By Targeting Smad3

(2019) Jie Yao et al.   OncoTargets and Therapy

Long non-coding RNA SNHG1 indicates poor prognosis and facilitates disease progression in acute myeloid leukemia

(2019) Ming Tian et al.   Biology Open

Chemokines modulate the tumour microenvironment in pituitary neuroendocrine tumours

(2019) Pedro Marques et al.   Acta Neuropathologica Communications

The Microenvironment of Pituitary Tumors—Biological and Therapeutic Implications

(2019) Mirela Diana Ilie et al.   Cancers

Identification of Transcriptional Metabolic Dysregulation in Subtypes of Pituitary Adenoma by Integrated Bioinformatics Analysis

(2019) Jintao Hu et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Pangenomic Classification of Pituitary Neuroendocrine Tumors

(2019) Mario Neou et al.   CANCER CELL

Pituitary tumour fibroblast-derived cytokines influence tumour aggressiveness

(2019) Pedro Marques et al.   ENDOCRINE-RELATED CANCER

Multiomics-Based Signaling Pathway Network Alterations in Human Non-functional Pituitary Adenomas

(2019) Ying Long et al.   Frontiers in Endocrinology

New WHO classification of pituitary adenomas (4th edition): assessment of pituitary transcription factors and the prognostic histological factors

(2018) Hiroshi Nishioka et al.   Brain Tumor Pathology

The Epigenomic Landscape of Pituitary Adenomas Reveals Specific Alterations and Differentiates Among Acromegaly, Cushing's Disease and Endocrine-Inactive Subtypes

(2018) Matthew P. Salomon et al.   CLINICAL CANCER RESEARCH

Decreased expression of SFRP2 promotes development of the pituitary corticotroph adenoma by upregulating Wnt signaling

(2018) Jie Ren et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Genomic Alterations and Complex Subclonal Architecture in Sporadic GH-Secreting Pituitary Adenomas

(2018) Mirella Hage et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Gene expression profiling in human corticotrope tumors reveals distinct, neuroendocrine profiles

(2018) Maria Francesca Cassarino et al.   JOURNAL OF NEUROENDOCRINOLOGY

Epidemiology, clinical presentation and diagnosis of non-functioning pituitary adenomas

(2018) Georgia Ntali et al.   Pituitary

miR-16-5p inhibits chordoma cell proliferation, invasion and metastasis by targeting Smad3

(2018) Hongliang Zhang et al.   Cell Death & Disease

Multi-chaperone function modulation and association with cytoskeletal proteins are key features of the function of AIP in the pituitary gland

(2018) Laura C. Hernández-Ramírez et al.   Oncotarget

miR-143-3p inhibits the proliferation, migration and invasion in osteosarcoma by targeting FOSL2

(2018) Xiangran Sun et al.   Scientific Reports

Diagnostic accuracy and comparison of BIPSS in response to lysine vasopressin and hCRH

(2018) Kush Dev Singh Jarial et al.   Endocrine Connections

Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/β-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors

(2018) Heyuan Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MicroRNA-93 mediates cabergoline-resistance by targeting ATG7 in prolactinoma

(2018) Zerui Wu et al.   JOURNAL OF ENDOCRINOLOGY

A Consensus Statement on acromegaly therapeutic outcomes

(2018) Shlomo Melmed et al.   Nature Reviews Endocrinology

miR-665 promotes hepatocellular carcinoma cell migration, invasion, and proliferation by decreasing Hippo signaling through targeting PTPRB

(2018) Yuanchang Hu et al.   Cell Death & Disease

Lnc-SNHG1 may promote the progression of non-small cell lung cancer by acting as a sponge of miR-497

(2018) Zhanxia Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours

(2018) Ze Rui Wu et al.   Nature Communications

Genome-wide identification of lncRNAs and mRNAs differentially expressed in non-functioning pituitary adenoma and construction of an lncRNA-mRNA co-expression network

(2018) Weikang Xing et al.   Biology Open

Tumor suppressor miR-145-5p sensitizes prolactinoma to bromocriptine by downregulating TPT1

(2018) M. Jian et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Clinical Identification of Oncogenic Drivers and Copy-Number Alterations in Pituitary Tumors

(2017) Wenya Linda Bi et al.   ENDOCRINOLOGY

Gene expression profiling of fast- and slow-growing non-functioning gonadotroph pituitary adenomas

(2017) Camilla Maria Falch et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Corticotroph Pituitary Carcinoma in a Patient With Lynch Syndrome (LS) and Pituitary Tumors in a Nationwide LS Cohort

(2017) Daniel Bengtsson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Aggressive Behavior in Silent Subtype III Pituitary Adenomas May Depend on Suppression of Local Immune Response: A Whole Transcriptome Analysis

(2017) Timothy E. Richardson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Genetics of pituitary adenomas

(2017) Márta Korbonits et al.   NEUROLOGY INDIA

Expression of cell cycle regulators and biomarkers of proliferation and regrowth in human pituitary adenomas

(2017) Mark Gruppetta et al.   Pituitary

Somatostatin receptor ligands in the treatment of acromegaly

(2017) Monica R. Gadelha et al.   Pituitary

MicroRNA-16-5p overexpression suppresses proliferation and invasion as well as triggers apoptosis by targeting VEGFA expression in breast carcinoma

(2017) Yunhui Qu et al.   Oncotarget

A Novel Invasive-Related Biomarker in Three Subtypes of Nonfunctioning Pituitary Adenomas

(2017) Yong Chen et al.   World Neurosurgery

miRNA-34c-5p inhibits amphiregulin-induced ovarian cancer stemness and drug resistance via downregulation of the AREG-EGFR-ERK pathway

(2017) S-L Tung et al.   Oncogenesis

Transcriptome Analysis Showed a Differential Signature between Invasive and Non-invasive Corticotrophinomas

(2017) Leonardo Jose Tadeu de Araújo et al.   Frontiers in Endocrinology

The genome-wide mutational landscape of pituitary adenomas

(2016) Zhi-Jian Song et al.   CELL RESEARCH

Landscape of Genomic Alterations in Pituitary Adenomas

(2016) Wenya Linda Bi et al.   CLINICAL CANCER RESEARCH

Novel Genetic Causes of Pituitary Adenomas

(2016) F. Caimari et al.   CLINICAL CANCER RESEARCH

Somatostatin analogues in acromegaly and gastroenteropancreatic neuroendocrine tumours: past, present and future

(2016) Kjell Öberg et al.   ENDOCRINE-RELATED CANCER

Polymorphisms inMEN1andDRD2genes are associated with the occurrence and characteristics of pituitary adenomas

(2016) Raitis Peculis et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Whole-Exome Sequencing Study of Thyrotropin-Secreting Pituitary Adenomas

(2016) Santosh Sapkota et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Ensembl 2017

(2016) Bronwen L. Aken et al.   NUCLEIC ACIDS RESEARCH

Somatostatin receptor ligands in acromegaly: clinical response and factors predicting resistance

(2016) Rosa Maria Paragliola et al.   Pituitary

Integrative proteomics and transcriptomics identify novel invasive-related biomarkers of non-functioning pituitary adenomas

(2016) Sheng-Yuan Yu et al.   TUMOR BIOLOGY

Whole-exome sequencing identifies variants in invasive pituitary adenomas

(2016) Xiaolei Lan et al.   Oncology Letters

Genome-wide analysis of differentially expressed lncRNAs and mRNAs in primary gonadotrophin adenomas by RNA-seq

(2016) Jiye Li et al.   Oncotarget

Recurrent gain-of-function USP8 mutations in Cushing's disease

(2015) Zeng-Yi Ma et al.   CELL RESEARCH

Downregulation of miR-375 in aldosterone-producing adenomas promotes tumour cell growth via MTDH

(2015) Juan He et al.   CLINICAL ENDOCRINOLOGY

Small and Long Non-Coding RNAs: Novel Targets in Perspective Cancer Therapy

(2015) Chi Li et al.   CURRENT GENOMICS

Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients

(2015) Liliya Rostomyan et al.   ENDOCRINE-RELATED CANCER

The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing's disease

(2015) K. Hayashi et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas

(2015) Cristina L Ronchi et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Whole-Genome Sequencing of Growth Hormone (GH)-Secreting Pituitary Adenomas

(2015) Niko Välimäki et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Gene of the Ubiquitin-Specific Protease 8 Is Frequently Mutated in Adenomas Causing Cushing's Disease

(2015) Luis G. Perez-Rivas et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pituitary Adenoma With Paraganglioma/Pheochromocytoma (3PAs) and Succinate Dehydrogenase Defects in Humans and Mice

(2015) Paraskevi Xekouki et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes

(2015) Haiqing Hu et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Computational analysis identifies invasion-associated genes in pituitary adenomas

(2015) CHANGJUN CAO et al.   Molecular Medicine Reports

Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma

(2015) Zhao Ye et al.   NATURE GENETICS

The effects of somatostatin analogue therapy on pituitary tumor volume in patients with acromegaly

(2015) Annamaria Colao et al.   Pituitary

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergoline

(2015) Shao Jian Lin et al.   Oncotarget

Cushing's syndrome: epidemiology and developments in disease management

(2015) Richard Feelders et al.   Clinical Epidemiology

Pituitary blastoma: a pathognomonic feature of germ-line DICER1 mutations

(2014) Leanne de Kock et al.   ACTA NEUROPATHOLOGICA

Epidemiology and etiopathogenesis of pituitary adenomas

(2014) Elena D. Aflorei et al.   JOURNAL OF NEURO-ONCOLOGY

The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas

(2014) Li Zhenye et al.   Journal of Translational Medicine

MicroRNA expression profile of bromocriptine-resistant prolactinomas

(2014) Zhe Bao Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mutations in the deubiquitinase gene USP8 cause Cushing's disease

(2014) Martin Reincke et al.   NATURE GENETICS

PRKACB and Carney Complex

(2014) Antonella Forlino et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation

(2014) Giampaolo Trivellin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System

(2014) Federica Barbieri et al.   International Journal of Endocrinology

Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival

(2013) Weimin Chen et al.   CELL CYCLE

Genetic analysis in young patients with sporadic pituitary macroadenomas: besides AIP don't forget MEN1 genetic analysis

(2013) Thomas Cuny et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Whole-Exome Sequencing Studies of Nonfunctioning Pituitary Adenomas

(2013) Paul J. Newey et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma

(2013) Yunli Zhou et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Identification of Differentially Coexpressed Genes in Gonadotrope Tumors and Normal Pituitary Using Bioinformatics Methods

(2013) Tao Cai et al.   PATHOLOGY & ONCOLOGY RESEARCH

p21 overexpression sensitizes osteosarcoma U2OS cells to cisplatin via evoking caspase-3 and Bax/Bcl-2 cascade

(2013) Yong Ding et al.   TUMOR BIOLOGY

MicroRNA-143 suppresses gastric cancer cell growth and induces apoptosis by targeting COX-2

(2013) Xiao-Li Wu   WORLD JOURNAL OF GASTROENTEROLOGY

Gene Expression Profiling Identifies ESRP1 as a Potential Regulator of Epithelial Mesenchymal Transition in Somatotroph Adenomas from a Large Cohort of Patients with Acromegaly

(2012) Tove Lekva et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Towards an integrated molecular and clinical strategy to predict early recurrence in surgically resected non-functional pituitary adenomas

(2012) Nicholas F. Marko et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Plasma specific miRNAs as predictive biomarkers for diagnosis and prognosis of glioma

(2012) Qiong Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Identification of Growth Arrest and DNA-Damage-Inducible Gene β (GADD45β) as a Novel Tumor Suppressor in Pituitary Gonadotrope Tumors

(2011) Katherine A. Michaelis et al.   ENDOCRINOLOGY

Screening for acromegaly by application of a simple questionnaire evaluating the enlargement of extremities in adult patients seen at primary health care units

(2011) Pedro Weslley Rosario et al.   Pituitary

Isolated familial somatotropinoma: 11Q13-LOH and gene/protein expression analysis suggests a possible involvement of aip also in non-pituitary tumorigenesis

(2010) Rodrigo A. Toledo et al.   Clinics

Differential gene expression profiles of invasive and non-invasive non-functioning pituitary adenomas based on microarray analysis

(2010) Françoise Galland et al.   ENDOCRINE-RELATED CANCER

The Deubiquitinating Enzyme USP8 Promotes Trafficking and Degradation of the Chemokine Receptor 4 at the Sorting Endosome

(2010) Ilana Berlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of microRNA length variety

(2010) Julia Starega-Roslan et al.   NUCLEIC ACIDS RESEARCH

GeneCards Version 3: the human gene integrator

(2010) M. Safran et al.   Database-The Journal of Biological Databases and Curation

The epidemiology and genetics of pituitary adenomas

(2009) Adrian F. Daly et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

A heritable predisposition to pituitary tumors

(2009) William T. Couldwell et al.   Pituitary

Overexpression of Stromal Cell-Derived Factor 1 and Its Receptor CXCR4 Induces Autocrine/Paracrine Cell Proliferation in Human Pituitary Adenomas

(2008) F. Barbieri et al.   CLINICAL CANCER RESEARCH

High prevalence of biochemical acromegaly in primary care patients with elevated IGF-1 levels

(2008) H. J. Schneider et al.   CLINICAL ENDOCRINOLOGY

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Selective Loss ofMEG3Expression and Intergenic Differentially Methylated Region Hypermethylation in theMEG3/DLK1Locus in Human Clinically Nonfunctioning Pituitary Adenomas

(2008) Roger Gejman et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Kcnq1ot1 Antisense Noncoding RNA Mediates Lineage-Specific Transcriptional Silencing through Chromatin-Level Regulation

(2008) Radha Raman Pandey et al.   MOLECULAR CELL

Prevalence of gsp oncogene in somatotropinomas and clinically non-functioning pituitary adenomas: our experience

(2008) Giselle Fernandes Taboada et al.   Pituitary

Molecular pathogenesis of human prolactinomas identified by gene expression profiling, RT-qPCR, and proteomic analyses

(2008) Chheng-Orn Evans et al.   Pituitary