Attribution of NF-κB Activity to CHUK/IKKα-Involved Carcinogenesis

NLRP3 Inhibition Ameliorates Severe Cutaneous Autoimmune Manifestations in a Mouse Model of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy–Like Disease

(2020) Feng Zhu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Intestinal non-canonical NFκB signaling shapes the local and systemic immune response

(2019) Sadeesh K. Ramakrishnan et al.   Nature Communications

LncRNA PCAT1 activates AKT and NF-κB signaling in castration-resistant prostate cancer by regulating the PHLPP/FKBP51/IKKα complex

(2019) Zhiqun Shang et al.   NUCLEIC ACIDS RESEARCH

Integrity of IKK/NF-κB Shields Thymic Stroma That Suppresses Susceptibility to Autoimmunity, Fungal Infection, and Carcinogenesis

(2018) Feng Zhu et al.   BIOESSAYS

IκB Kinase α Is Required for Development and Progression ofKRAS-Mutant Lung Adenocarcinoma

(2018) Malamati Vreka et al.   CANCER RESEARCH

IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways

(2018) Na-Young Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage inducible nitric oxide synthase promotes the initiation of lung squamous cell carcinoma by maintaining circulated inflammation

(2018) Zane Gray et al.   Cell Death & Disease

Esophageal Expression of Active IκB Kinase-β in Mice Up-Regulates Tumor Necrosis Factor and Granulocyte-Macrophage Colony-Stimulating Factor, Promoting Inflammation and Angiogenesis

(2016) Marie-Pier Tétreault et al.   GASTROENTEROLOGY

Role of the RANK/RANKL pathway in breast cancer

(2016) Ludwig Kiesel et al.   MATURITAS

Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity

(2015) Paul R. Giacomin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A nonsense mutation in IKBKB causes combined immunodeficiency

(2014) T. Mousallem et al.   BLOOD

Immunodeficiency and disseminated mycobacterial infection associated with homozygous nonsense mutation of IKKβ

(2014) Siobhan O. Burns et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immunodeficiency Associated with a Nonsense Mutation of IKBKB

(2014) Christian Nielsen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The Lymphotoxin Pathway Regulates Aire-Independent Expression of Ectopic Genes and Chemokines in Thymic Stromal Cells

(2014) N. Seach et al.   JOURNAL OF IMMUNOLOGY

IKKα restoration via EZH2 suppression induces nasopharyngeal carcinoma differentiation

(2014) Min Yan et al.   Nature Communications

IKKα negatively regulates ASC-dependent inflammasome activation

(2014) Bradley N. Martin et al.   Nature Communications

The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas

(2013) Zuoxiang Xiao et al.   CANCER CELL

Tumor Necrosis Factor Receptor Signaling in Keratinocytes Triggers Interleukin-24-Dependent Psoriasis-like Skin Inflammation in Mice

(2013) Snehlata Kumari et al.   IMMUNITY

Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice

(2013) Ning Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficiency of Innate and Acquired Immunity Caused by an IKBKB Mutation

(2013) Ulrich Pannicke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model

(2012) Yifeng Xia et al.   NATURE CELL BIOLOGY

IKKα represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin

(2011) B Liu et al.   CELL DEATH AND DIFFERENTIATION

IKK  Overexpression Leads to Pathologic Lesions in Stratified Epithelia and Exocrine Glands and to Tumoral Transformation of Oral Epithelia

(2011) A. Page et al.   MOLECULAR CANCER RESEARCH

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1

(2011) Noula Shembade et al.   NATURE IMMUNOLOGY

IKKα takes control of canonical NF-κB activation

(2011) Christiane Pelzer et al.   NATURE IMMUNOLOGY

An Innate Role for IL-17

(2011) M. Dominguez-Villar et al.   SCIENCE

Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity

(2011) A. Puel et al.   SCIENCE

Reduction of IKKα Expression Promotes Chronic Ultraviolet B Exposure-Induced Skin Inflammation and Carcinogenesis

(2010) Xiaojun Xia et al.   AMERICAN JOURNAL OF PATHOLOGY

IKKβ Leads to an Inflammatory Skin Disease Resembling Interface Dermatitis

(2010) Angustias Page et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MutantCHUKand Severe Fetal Encasement Malformation

(2010) Jenni Lahtela et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aire

(2009) Diane Mathis et al.   Annual Review of Immunology

Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma

(2009) Etienne Meylan et al.   NATURE

IKKα Is Required to Maintain Skin Homeostasis and Prevent Skin Cancer

(2008) Bigang Liu et al.   CANCER CELL

The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

(2008) Taishin Akiyama et al.   IMMUNITY

IKK  is a critical coregulator of a Smad4-independent TGF -Smad2/3 signaling pathway that controls keratinocyte differentiation

(2008) P. Descargues et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA