CTLA-4 in Regulatory T Cells for Cancer Immunotherapy

CTLA-4 expression by B-1a B cells is essential for immune tolerance

(2021) Yang Yang et al.   Nature Communications

IL36 Cooperates With Anti-CTLA-4 mAbs to Facilitate Antitumor Immune Responses

(2020) Qiuxia Qu et al.   Frontiers in Immunology

Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects

(2020) Chunxiao Li et al.   Molecular Cancer

Cytotoxic CD8+ T cells in cancer and cancer immunotherapy

(2020) Hans Raskov et al.   BRITISH JOURNAL OF CANCER

Cancer statistics for adolescents and young adults, 2020

(2020) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The role of macrophages type 2 and T-regs in immune checkpoint inhibitor related adverse events

(2020) Daniela Mihic-Probst et al.   IMMUNOBIOLOGY

Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions

(2020) Guoming Zeng et al.   Cancer Management and Research

CD47/SIRPα blocking peptide identification and synergistic effect with irradiation for cancer immunotherapy

(2020) Hongfei Wang et al.   Journal for ImmunoTherapy of Cancer

Combination of radiotherapy and suppression of Tregs enhances abscopal antitumor effect and inhibits metastasis in rectal cancer

(2020) Dengbo Ji et al.   Journal for ImmunoTherapy of Cancer

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cancer immunotherapy with check point inhibitor can cause autoimmune adverse events due to loss of Treg homeostasis

(2019) Prabhakaran Kumar et al.   SEMINARS IN CANCER BIOLOGY

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

(2019) Yosuke Togashi et al.   Nature Reviews Clinical Oncology

Innate, innate-like and adaptive lymphocytes in the pathogenesis of MS and EAE

(2019) Luc Van Kaer et al.   Cellular & Molecular Immunology

The CTLA-4 x OX40 bispecific antibody ATOR-1015 induces anti-tumor effects through tumor-directed immune activation

(2019) Anne Månsson Kvarnhammar et al.   Journal for ImmunoTherapy of Cancer

Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy

(2019) Yan Zhang et al.   CELL RESEARCH

New insights on T-cell self-tolerance

(2019) Jaeu Yi et al.   CURRENT OPINION IN IMMUNOLOGY

A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy

(2018) Xuexiang Du et al.   CELL RESEARCH

Identification of new allosteric sites and modulators of AChE through computational and experimental tools

(2018) Carlos Roca et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synergy of Immune Checkpoint Blockade with a Novel Synthetic Consensus DNA Vaccine Targeting TERT

(2018) Elizabeth K. Duperret et al.   MOLECULAR THERAPY

Anti-CTLA-4 antibodies in cancer immunotherapy: selective depletion of intratumoral regulatory T cells or checkpoint blockade?

(2018) Fei Tang et al.   Cell and Bioscience

Tumor-Specific Inhibition of In Situ Vaccination by Distant Untreated Tumor Sites

(2018) Zachary S. Morris et al.   Cancer Immunology Research

Unraveling Natural Killer T-Cells Development

(2018) Sabrina Bianca Bennstein   Frontiers in Immunology

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity

(2018) Chien-Chun Steven Pai et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8+ T cells in the tumor microenvironment

(2018) Yasuko Tada et al.   Journal for ImmunoTherapy of Cancer

Immune checkpoint Ab enhances the antigen-specific anti-tumor effects by modulating both dendritic cells and regulatory T lymphocytes

(2018) Nai-Yun Sun et al.   CANCER LETTERS

MAIT cells: an historical and evolutionary perspective

(2017) Olivier Lantz et al.   IMMUNOLOGY AND CELL BIOLOGY

Improved Method for the Identification and Validation of Allosteric Sites

(2017) Kun Song et al.   Journal of Chemical Information and Modeling

The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8 + T cells in the tumor microenvironment

(2017) Jason B. Williams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment

(2017) Jingjing Xie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab

(2017) Udupi A. Ramagopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNFR2: A Novel Target for Cancer Immunotherapy

(2017) Éva S. Vanamee et al.   TRENDS IN MOLECULAR MEDICINE

Enhancement of antitumor immunity by combination of anti-CTLA-4 antibody and radioimmunotherapy through the suppression of Tregs

(2017) Cheol-Hun Son et al.   Oncology Letters

Structural basis of the therapeutic anti-PD-L1 antibody atezolizumab

(2017) Fei Zhang et al.   Oncotarget

Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies

(2017) Mengnan He et al.   Oncotarget

Treg Depletion Licenses T Cell–Driven HEV Neogenesis and Promotes Tumor Destruction

(2017) Emily J. Colbeck et al.   Cancer Immunology Research

The Immunosuppressive Effect of CTLA4 Immunoglobulin Is Dependent on Regulatory T Cells at Low But Not High Doses

(2016) C. Schwarz et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Interleukin-35 Limits Anti-Tumor Immunity

(2016) Meghan E. Turnis et al.   IMMUNITY

Parallels and differences between innate and adaptive lymphocytes

(2016) Sammy Bedoui et al.   NATURE IMMUNOLOGY

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

(2016) Takuro Saito et al.   NATURE MEDICINE

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

The epigenetic landscape of T cell exhaustion

(2016) D. R. Sen et al.   SCIENCE

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

(2015) Alan Serrels et al.   CELL

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

(2015) Alison M. Paterson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy

(2015) W. Peng et al.   Cancer Discovery

Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis

(2015) Bin Shang et al.   Scientific Reports

γδT Cells: First Line of Defense and Beyond

(2014) Yueh-hsiu Chien et al.   Annual Review of Immunology

Disruption of CCR5-Dependent Homing of Regulatory T Cells Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer

(2014) M. C. B. Tan et al.   JOURNAL OF IMMUNOLOGY

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation

(2014) H. Morikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of self-reactive CD8+T cells with an anergic phenotype in healthy individuals

(2014) Yuka Maeda et al.   SCIENCE

Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo

(2014) Linda C Sandin et al.   OncoImmunology

Future directions for peptide therapeutics development

(2013) Allan A. Kaspar et al.   DRUG DISCOVERY TODAY

Depleting tumor-specific Tregs at a single site eradicates disseminated tumors

(2013) Aurélien Marabelle et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans

(2013) D. Sugiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells

(2013) S. Spranger et al.   Science Translational Medicine

T-Cell Trafficking Facilitated by High Endothelial Venules Is Required for Tumor Control after Regulatory T-Cell Depletion

(2012) J. P. Hindley et al.   CANCER RESEARCH

The T-cell Receptor Repertoire of Tumor-Infiltrating Regulatory T Lymphocytes Is Skewed Toward Public Sequences

(2012) A. Sainz-Perez et al.   CANCER RESEARCH

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

(2012) Naganari Ohkura et al.   IMMUNITY

Cutting Edge: CTLA-4 on Effector T Cells Inhibits In Trans

(2012) E. Corse et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Increase the Avidity of Primary CD8+ T Cell Responses and Promote Memory

(2012) L. Pace et al.   SCIENCE

IL-17 + Regulatory T Cells in the Microenvironments of Chronic Inflammation and Cancer

(2011) Ilona Kryczek et al.   JOURNAL OF IMMUNOLOGY

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

(2011) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Intratumoral forkhead box P3-positive regulatory T cells predict poor survival in cyclooxygenase-2-positive uveal melanoma

(2010) Dimitrios Mougiakakos et al.   CANCER

Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

(2010) J. P. Hindley et al.   CANCER RESEARCH

Tremelimumab (anti-CTLA4) mediates immune responses mainly by direct activation of T effector cells rather than by affecting T regulatory cells

(2010) Sameena Khan et al.   CLINICAL IMMUNOLOGY

Rigid-body Ligand Recognition Drives Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Receptor Triggering

(2010) Chao Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockade of CCL1 Inhibits T Regulatory Cell Suppressive Function Enhancing Tumor Immunity without Affecting T Effector Responses

(2010) D. B. Hoelzinger et al.   JOURNAL OF IMMUNOLOGY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity

(2010) N. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FOXP3 Defines Regulatory T Cells in Human Tumor and Autoimmune Disease

(2009) I. Kryczek et al.   CANCER RESEARCH

Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells

(2009) Gang Wei et al.   IMMUNITY

CD4+regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

(2009) Randall H. Friedline et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

CD4+ Regulatory T Cells Control TH17 Responses in a Stat3-Dependent Manner

(2009) A. Chaudhry et al.   SCIENCE

CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion

(2008) B. Kavanagh et al.   BLOOD

Regulatory T cells in health and disease

(2008) Ciriaco A. Piccirillo   CYTOKINE

Multiple roles for CD4+T cells in anti-tumor immune responses

(2008) Richard Kennedy et al.   IMMUNOLOGICAL REVIEWS

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE