Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 63, Issue -, Pages 14-20Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2019.10.002
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Funding
- National Health and Medical Research Council [APP1145714, APP1078243]
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Self-tolerance of T cells is maintained by a combination of thymic negative selection and suppression by T regulatory cells (Tregs); both processes are driven by recognition of self MHC ligands. Treg function ensures that most T cells remain quiescent as naive cells, but enables some T cells to proliferate and differentiate into cells with a memory phenotype (MP). In this review, we discuss how Tregs shape this compartmentalization of T cells into subsets of naive and MP T cells.
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