The role of caveolin-1 in the biofate and efficacy of anti-tumor drugs and their nano-drug delivery systems

Involvement of Caveolin-1-mediated transcytosis in the intratumoral accumulation of liposomes

(2020) Yu Sakurai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Caveolin-1 Promotes Chemoresistance of Gastric Cancer Cells to Cisplatin by Activating WNT/β-Catenin Pathway

(2020) Xi Wang et al.   Frontiers in Oncology

Tumor extravasation and infiltration as barriers of nanomedicine for high efficacy: The current status and transcytosis strategy

(2020) Quan Zhou et al.   BIOMATERIALS

Drug uptake-based chemoresistance in breast cancer treatment

(2020) Helena Muley et al.   BIOCHEMICAL PHARMACOLOGY

Mechanical cues modulate cellular uptake of nanoparticles in cancer via clathrin-mediated and caveolae-mediated endocytosis pathways

(2019) Xiao Wei et al.   Nanomedicine

Caveolin‐1 knockdown increases the therapeutic sensitivity of lung cancer to cisplatin‐induced apoptosis by repressing Parkin‐related mitophagy and activating the ROCK1 pathway

(2019) Yi Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy

(2019) Quan Zhou et al.   Nature Nanotechnology

Transcytosis of Nanomedicine for Tumor Penetration

(2019) Yan Liu et al.   NANO LETTERS

Caveolin-mediated endocytosis of the Chlamydia M278 outer membrane peptide encapsulated in poly(lactic acid)-Poly(ethylene glycol) nanoparticles by mouse primary dendritic cells enhances specific immune effectors mediated by MHC class II and CD4 + T cells

(2018) Saurabh Dixit et al.   BIOMATERIALS

Liposomal Treatment of Cancer Cells Modulates Uptake Pathway of Polymeric Nanoparticles by Altering Membrane Stiffness

(2018) Shengnan Xiang et al.   Small

Metformin-induced caveolin-1 expression promotes T-DM1 drug efficacy in breast cancer cells

(2018) Yuan-Chiang Chung et al.   Scientific Reports

Metabolic Reprogramming of Cancer Associated Fibroblasts: The Slavery of Stromal Fibroblasts

(2018) Angelica Avagliano et al.   Biomed Research International

Multifunctional Nanoparticles Enable Efficient Oral Delivery of Biomacromolecules via Improving Payload Stability and Regulating the Transcytosis Pathway

(2018) Yaxian Zheng et al.   ACS Applied Materials & Interfaces

Caveolin-1 expression predicts efficacy of weekly nab-paclitaxel plus gemcitabine for metastatic breast cancer in the phase II clinical trial

(2018) Yannan Zhao et al.   BMC CANCER

Enhanced anticancer activity and intracellular uptake of paclitaxel-containing solid lipid nanoparticles in multidrug-resistant breast cancer cells

(2018) Wenting Xu et al.   International Journal of Nanomedicine

Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy

(2018) Patrícia M. R. Pereira et al.   Nature Communications

Caveolae-Mediated Endocytosis as a Novel Mechanism of Resistance to Trastuzumab Emtansine (T-DM1)

(2017) Matthew Sung et al.   MOLECULAR CANCER THERAPEUTICS

Metabolic reprogramming of carcinoma-associated fibroblasts and its impact on metabolic heterogeneity of tumors

(2017) Duojiao Wu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development

(2017) Lindsay Wilde et al.   SEMINARS IN ONCOLOGY

Engineering of caveolae-specific self-micellizing anticancer lipid nanoparticles to enhance the chemotherapeutic efficacy of oxaliplatin in colorectal cancer cells

(2016) Pasupathi Sundaramoorthy et al.   Acta Biomaterialia

Overexpression of caveolin-1 in inflammatory breast cancer cells enables IBC-specific gene delivery and prodrug conversion using histone-targeted polyplexes

(2016) Nikki L. Ross et al.   BIOTECHNOLOGY AND BIOENGINEERING

Nab-paclitaxel for the treatment of triple-negative breast cancer: Rationale, clinical data and future perspectives

(2016) Francesco Schettini et al.   CANCER TREATMENT REVIEWS

Journey to the Center of the Cell: Current Nanocarrier Design Strategies Targeting Biopharmaceuticals to the Cytoplasm and Nucleus

(2016) Erik V. Munsell et al.   CURRENT PHARMACEUTICAL DESIGN

Cholesterol-modified poly(lactide-co-glycolide) nanoparticles for tumor-targeted drug delivery

(2016) Jeong-Jun Lee et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Caveolae: One Function or Many?

(2016) Jade P.X. Cheng et al.   TRENDS IN CELL BIOLOGY

Downregulation of caveolin-1 increases the sensitivity of drug-resistant colorectal cancer HCT116 cells to 5-fluorouracil

(2016) Zhaoyang Li et al.   Oncology Letters

On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer

(2016) Judith Penkert et al.   Oncotarget

Prognostic value of Caveolin-1 in patients treated with radical prostatectomy: a multicentric validation study

(2015) Romain Mathieu et al.   BJU INTERNATIONAL

Albumin corona on nanoparticles – a strategic approach in drug delivery

(2015) Jessy Mariam et al.   DRUG DELIVERY

Metabolic reprogramming of the tumour microenvironment

(2015) Yazhi Xing et al.   FEBS Journal

Caveolae - mechanosensitive membrane invaginations linked to actin filaments

(2015) A. Echarri et al.   JOURNAL OF CELL SCIENCE

Caveolin-1 mediates chemoresistance in cisplatin-resistant ovarian cancer cells by targeting apoptosis through the Notch-1/Akt/NF-κB pathway

(2015) WEI ZOU et al.   ONCOLOGY REPORTS

Enhanced Gene Silencing through Human Serum Albumin-Mediated Delivery of Polyethylenimine-siRNA Polyplexes

(2015) Elena Nicolì et al.   PLoS One

Caveolin and cavin family members: Dual roles in cancer

(2014) Reshu Gupta et al.   BIOCHIMIE

Trastuzumab emtansine: mechanisms of action and drug resistance

(2014) Mark Barok et al.   BREAST CANCER RESEARCH

Src/caveolin-1-regulated EGFR activation antagonizes TRAIL-induced apoptosis in gastric cancer cells

(2014) LING XU et al.   ONCOLOGY REPORTS

Differential uptake of nanoparticles by endothelial cells through polyelectrolytes with affinity for caveolae

(2014) J. Voigt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Value of caveolin-1 in cancer progression and prognosis: Emphasis on cancer-associated fibroblasts, human cancer cells and mechanism of caveolin-1 expression (Review)

(2014) DALI CHEN et al.   Oncology Letters

Loss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progression

(2013) Gustavo Ayala et al.   JOURNAL OF PATHOLOGY

Implications of receptor-mediated endocytosis and intracellular trafficking dynamics in the development of antibody drug conjugates

(2013) Michael Ritchie et al.   mAbs

Caveolin-1 abrogates TGF-β mediated hepatocyte apoptosis

(2013) C Meyer et al.   Cell Death & Disease

Identification of Caveolin-1 as a Potential Causative Factor in the Generation of Trastuzumab Resistance in Breast Cancer Cells

(2013) Sreeja C Sekhar et al.   Journal of Cancer

Polymeric Nucleic Acid Vehicles Exploit Active Interorganelle Trafficking Mechanisms

(2012) Katye M. Fichter et al.   ACS Nano

Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival

(2012) Karen N. Wu et al.   CELL CYCLE

Gemcitabine reactivates epigenetically silenced genes and functions as a DNA methyltransferase inhibitor

(2012) STEVEN G. GRAY et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Caveolin-1, caveolae, and glioblastoma

(2012) M.-O. Parat et al.   NEURO-ONCOLOGY

Caveolin-1 and Cancer Metabolism in the Tumor Microenvironment: Markers, Models, and Mechanisms

(2011) Federica Sotgia et al.   Annual Review of Pathology-Mechanisms of Disease

Towards a new “stromal-based” classification system for human breast cancer prognosis and therapy

(2011) Agnieszka K. Witkiewicz et al.   CELL CYCLE

An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease spread and epithelial Akt activation

(2011) Dolores Di Vizio et al.   CELL CYCLE

Stromal Caveolin-1 Expression in Breast Carcinoma. Correlation with Early Tumor Recurrence and Clinical Outcome

(2011) Saba Mohamed El-Gendi et al.   PATHOLOGY & ONCOLOGY RESEARCH

Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

(2010) Yulia Komarova et al.   Annual Review of Physiology

Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 down-regulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy

(2010) Isabelle Mercier et al.   CANCER BIOLOGY & THERAPY

Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

(2010) Agnieszka K. Witkiewicz et al.   CANCER BIOLOGY & THERAPY

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Targeted delivery for breast cancer therapy: the history of nanoparticle-albumin-bound paclitaxel

(2010) Fausto Petrelli et al.   EXPERT OPINION ON PHARMACOTHERAPY

Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity

(2010) Tae Hyung Kim et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation

(2010) Arnold Hayer et al.   JOURNAL OF CELL BIOLOGY

Endocytosis of nanomedicines

(2010) Gaurav Sahay et al.   JOURNAL OF CONTROLLED RELEASE

RNA interference-directed caveolin-1 knockdown sensitizes SN12CPM6 cells to doxorubicin-induced apoptosis and reduces lung metastasis

(2010) Juwon Park et al.   TUMOR BIOLOGY

Size and Dynamics of Caveolae Studied Using Nanoparticles in Living Endothelial Cells

(2009) Zhenjia Wang et al.   ACS Nano

Caveolin-1 (P132L), a Common Breast Cancer Mutation, Confers Mammary Cell Invasiveness and Defines a Novel Stem Cell/Metastasis-Associated Gene Signature

(2009) Gloria Bonuccelli et al.   AMERICAN JOURNAL OF PATHOLOGY

Stromal Cell Expression of Caveolin-1 Predicts Outcome in Breast Cancer

(2009) Erica K. Sloan et al.   AMERICAN JOURNAL OF PATHOLOGY

An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers

(2009) Agnieszka K. Witkiewicz et al.   AMERICAN JOURNAL OF PATHOLOGY

The exploitation of differential endocytic pathways in normal and tumor cells in the selective targeting of nanoparticulate chemotherapeutic agents

(2009) Gaurav Sahay et al.   BIOMATERIALS

Efficient polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells

(2009) Nathan P. Gabrielson et al.   JOURNAL OF CONTROLLED RELEASE

Caveolin-1 Promotes Autoregulatory, Akt-Mediated Induction of Cancer-Promoting Growth Factors in Prostate Cancer Cells

(2009) L. Li et al.   MOLECULAR CANCER RESEARCH

Protein nanoparticles as drug carriers in clinical medicine

(2008) Michael J. Hawkins et al.   ADVANCED DRUG DELIVERY REVIEWS

Caveolin 1 and Caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype

(2008) S E Elsheikh et al.   BRITISH JOURNAL OF CANCER

Caveats of caveolin-1 in cancer progression

(2008) Elke Burgermeister et al.   CANCER LETTERS