Propagation of F-actin disassembly via Myosin15-Mical interactions

Actin at stereocilia tips is regulated by mechanotransduction and ADF/cofilin

(2021) Jamis McGrath et al.   CURRENT BIOLOGY

The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness

(2020) Fangfang Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability

(2019) Guillaume Jacquemet et al.   CURRENT BIOLOGY

GPSM2-GNAI Specifies the Tallest Stereocilia and Defines Hair Bundle Row Identity

(2019) Abigail L.D. Tadenev et al.   CURRENT BIOLOGY

Genotype-phenotype correlation analysis of MYO15A variants in autosomal recessive non-syndromic hearing loss

(2019) Jing Zhang et al.   BMC Medical Genetics

MICALs

(2018) Laura Taylor Alto et al.   CURRENT BIOLOGY

The MICALs are a Family of F-actin Dismantling Oxidoreductases Conserved from Drosophila to Humans

(2018) Heng Wu et al.   Scientific Reports

Axon formation, extension, and navigation: only a neuroscience phenomenon?

(2018) Shannon K Rich et al.   CURRENT OPINION IN NEUROBIOLOGY

Regulated methionine oxidation by monooxygenases

(2017) Bruno Manta et al.   FREE RADICAL BIOLOGY AND MEDICINE

Emerging roles of MICAL family proteins – from actin oxidation to membrane trafficking during cytokinesis

(2017) Stéphane Frémont et al.   JOURNAL OF CELL SCIENCE

Retrograde semaphorin–plexin signalling drives homeostatic synaptic plasticity

(2017) Brian O. Orr et al.   NATURE

Stereocilia morphogenesis and maintenance through regulation of actin stability

(2017) Jamis McGrath et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome

(2017) Stephanie A. Mauriac et al.   Nature Communications

Catastrophic disassembly of actin filaments via Mical-mediated oxidation

(2017) Elena E. Grintsevich et al.   Nature Communications

Mutational Spectrum ofMYO15Aand the Molecular Mechanisms of DFNB3 Human Deafness

(2016) Atteeq U. Rehman et al.   HUMAN MUTATION

Cofilin-mediated actin dynamics promotes actin bundle formation during Drosophila bristle development

(2016) Jing Wu et al.   MOLECULAR BIOLOGY OF THE CELL

F-actin dismantling through a redox-driven synergy between Mical and cofilin

(2016) Elena E. Grintsevich et al.   NATURE CELL BIOLOGY

Myosin MyTH4-FERM structures highlight important principles of convergent evolution

(2016) Vicente José Planelles-Herrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gel-free mass spectrometry analysis ofDrosophila melanogasterheads

(2015) Jana Aradska et al.   PROTEOMICS

Length regulation of mechanosensitive stereocilia depends on very slow actin dynamics and filament-severing proteins

(2015) Praveena Narayanan et al.   Nature Communications

Self-organization of waves and pulse trains by molecular motors in cellular protrusions

(2015) A. Yochelis et al.   Scientific Reports

The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing

(2015) Qing Fang et al.   eLife

Cargo Recognition and Cargo-Mediated Regulation of Unconventional Myosins

(2014) Qing Lu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Evolution and Classification of Myosins, a Paneukaryotic Whole-Genome Approach

(2014) Arnau Sebé-Pedrós et al.   Genome Biology and Evolution

Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking

(2014) J. E. Bird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells

(2013) Tae-Jun Kwon et al.   HUMAN MOLECULAR GENETICS

MsrB1 and MICALs Regulate Actin Assembly and Macrophage Function via Reversible Stereoselective Methionine Oxidation

(2013) Byung Cheon Lee et al.   MOLECULAR CELL

SelR reverses Mical-mediated oxidation of actin to regulate F-actin dynamics

(2013) Ruei-Jiun Hung et al.   NATURE CELL BIOLOGY

Regulation of Stereocilia Length by Myosin XVa and Whirlin Depends on the Actin-Regulatory Protein Eps8

(2011) Uri Manor et al.   CURRENT BIOLOGY

Direct Redox Regulation of F-Actin Assembly and Disassembly by Mical

(2011) R.-J. Hung et al.   SCIENCE

Functional Null Mutations of MSRB3 Encoding Methionine Sulfoxide Reductase Are Associated with Human Deafness DFNB74

(2010) Zubair M. Ahmed et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Targeting of the Hair Cell Proteins Cadherin 23, Harmonin, Myosin XVa, Espin, and Prestin in an Epithelial Cell Model

(2010) L. Zheng et al.   JOURNAL OF NEUROSCIENCE

Mical links semaphorins to F-actin disassembly

(2010) Ruei-Jiun Hung et al.   NATURE

LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease

(2010) Dean S. Griffiths et al.   NATURE CELL BIOLOGY

Gelsolin Plays a Role in the Actin Polymerization Complex of Hair Cell Stereocilia

(2010) Philomena Mburu et al.   PLoS One

BrainTrap: a database of 3D protein expression patterns in the Drosophila brain

(2010) Seymour Knowles-Barley et al.   Database-The Journal of Biological Databases and Curation

Drosophilagrowth cones: A genetically tractable platform for the analysis of axonal growth dynamics

(2009) Natalia Sánchez-Soriano et al.   Developmental Neurobiology

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT