Length regulation of mechanosensitive stereocilia depends on very slow actin dynamics and filament-severing proteins

Live-cell imaging of actin dynamics reveals mechanisms of stereocilia length regulation in the inner ear

(2015) Meghan C. Drummond et al.   Nature Communications

Aip1 Destabilizes Cofilin-Saturated Actin Filaments by Severing and Accelerating Monomer Dissociation from Ends

(2014) Ambika V. Nadkarni et al.   CURRENT BIOLOGY

Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice

(2014) Ruth Taylor et al.   HUMAN MOLECULAR GENETICS

Aip1 Promotes Actin Filament Severing by Cofilin and Regulates Constriction of the Cytokinetic Contractile Ring

(2014) Qian Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization and regulation of an additional actin-filament-binding site in large isoforms of the stereocilia actin-bundling protein espin

(2014) L. Zheng et al.   JOURNAL OF CELL SCIENCE

Synergies between Aip1p and capping protein subunits (Acp1p and Acp2p) in clathrin-mediated endocytosis and cell polarization in fission yeast

(2014) Julien Berro et al.   MOLECULAR BIOLOGY OF THE CELL

Actin Filament Elongation in Arp2/3-Derived Networks Is Controlled by Three Distinct Mechanisms

(2013) Alphée Michelot et al.   DEVELOPMENTAL CELL

Biophysics of actin filament severing by cofilin

(2013) W. Austin Elam et al.   FEBS LETTERS

 -Actin and Fascin-2 Cooperate to Maintain Stereocilia Length

(2013) B. J. Perrin et al.   JOURNAL OF NEUROSCIENCE

Molecular architecture of the chick vestibular hair bundle

(2013) Jung-Bum Shin et al.   NATURE NEUROSCIENCE

Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2

(2013) David N. Furness et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Remodeling of Tip Links Underlies Mechanosensory Regeneration in Auditory Hair Cells

(2013) Artur A. Indzhykulian et al.   PLOS BIOLOGY

Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia

(2012) Duan-Sun Zhang et al.   NATURE

Fate-Restricted Neural Progenitors in the Mammalian Cerebral Cortex

(2012) S. J. Franco et al.   SCIENCE

Cofilin cooperates with fascin to disassemble filopodial actin filaments

(2011) D. Breitsprecher et al.   JOURNAL OF CELL SCIENCE

Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia

(2011) E. Caberlotto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of the Espin Actin-Bundling Proteins in the Morphogenesis and Stabilization of Hair Cell Stereocilia Revealed in CBA/CaJ Congenic Jerker Mice

(2011) Gabriella Sekerková et al.   PLoS Genetics

The cell biology of hearing

(2010) Martin Schwander et al.   JOURNAL OF CELL BIOLOGY

ADF/Cofilin: a functional node in cell biology

(2010) Barbara W. Bernstein et al.   TRENDS IN CELL BIOLOGY

β-Actin and γ-Actin Are Each Dispensable for Auditory Hair Cell Development But Required for Stereocilia Maintenance

(2010) Benjamin J. Perrin et al.   PLoS Genetics

Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging

(2009) Maryline Beurg et al.   NATURE NEUROSCIENCE

A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells

(2009) M. Schwander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers

(2008) Hao Yuan Kueh et al.   JOURNAL OF CELL BIOLOGY

Dynamic stabilization of actin filaments

(2008) H. Y. Kueh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA