A tumor-suppressive circular RNA mediates uncanonical integrin degradation by the proteasome in liver cancer

CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer

(2020) Hongbao Yang et al.   Molecular Cancer

Extracellular Vesicle-Mediated Delivery of CircSCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models

(2020) Li Yang et al.   CIRCULATION

The Circular RNA circSKA3 Binds Integrin β1 to Induce Invadopodium Formation Enhancing Breast Cancer Invasion

(2020) William W. Du et al.   MOLECULAR THERAPY

The expanding regulatory mechanisms and cellular functions of circular RNAs

(2020) Ling-Ling Chen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging New Concepts of Degrader Technologies

(2020) Yu Ding et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

(2020) Junjie Xu et al.   Molecular Cancer

Restriction of hepatitis B virus replication by c-Abl–induced proteasomal degradation of the viral polymerase

(2019) Lidan Hou et al.   Science Advances

Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance

(2019) Jonathan Cooper et al.   CANCER CELL

Circular RNA MAT2B Promotes Glycolysis and Malignancy of Hepatocellular Carcinoma Through the miR‐338‐3p/PKM2 Axis Under Hypoxic Stress

(2019) Qing Li et al.   HEPATOLOGY

The Cytoskeleton—A Complex Interacting Meshwork

(2019) Hohmann et al.   Cells

CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress

(2019) Qidong Li et al.   Cell Metabolism

Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice

(2019) Senlin Huang et al.   CIRCULATION

Therapeutic targeting of circ‐ CUX 1 / EWSR 1/ MAZ axis inhibits glycolysis and neuroblastoma progression

(2019) Huanhuan Li et al.   EMBO Molecular Medicine

Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation

(2019) Feng Yang et al.   Molecular Cancer

Engineering, delivery, and biological validation of artificial microRNA clusters for gene therapy applications

(2019) Vivek Bhaskaran et al.   Nature Protocols

Targeted protein degradation: expanding the toolbox

(2019) Matthieu Schapira et al.   NATURE REVIEWS DRUG DISCOVERY

N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

(2019) Ri-Xin Chen et al.   Nature Communications

Circular RNA Sequencing Identifies CircASAP1 as a Key Regulator in Hepatocellular Carcinoma Metastasis

(2019) Zhi‐Qiang Hu et al.   HEPATOLOGY

Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function

(2019) Xiaoyan Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1

(2018) Ling Fang et al.   CELL DEATH AND DIFFERENTIATION

Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing

(2018) Meng Duan et al.   CELL RESEARCH

Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma

(2018) Jian Yu et al.   JOURNAL OF HEPATOLOGY

VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling

(2018) Johannes van den Boom et al.   MOLECULAR CELL

Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome

(2018) Kapil V. Ramachandran et al.   MOLECULAR CELL

Circular RNAs in hepatocellular carcinoma: Functions and implications

(2018) Liyun Fu et al.   Cancer Medicine

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling

(2018) Ling-jie Sang et al.   MOLECULAR CELL

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Circular RNAs in cancer: an emerging key player

(2017) Yeping Dong et al.   Journal of Hematology & Oncology

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function

(2017) Kapil V Ramachandran et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HDOCK: a web server for protein–protein and protein–DNA/RNA docking based on a hybrid strategy

(2017) Yumeng Yan et al.   NUCLEIC ACIDS RESEARCH

Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma

(2017) Liang Shi et al.   Cell Death & Disease

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function

(2017) Kapil V Ramachandran et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Endogenous microRNA sponges: evidence and controversy

(2016) Daniel W. Thomson et al.   NATURE REVIEWS GENETICS

Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

(2016) William W. Du et al.   NUCLEIC ACIDS RESEARCH

Hepatocellular carcinoma

(2016) Josep M. Llovet et al.   Nature Reviews Disease Primers

Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis

(2015) Xing Guo et al.   NATURE CELL BIOLOGY

Correlation of circular RNA abundance with proliferation – exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis and normal human tissues

(2015) Anna Bachmayr-Heyda et al.   Scientific Reports

Androgen receptor enhances cell adhesion and decreases cell migration via modulating β1-integrin-AKT signaling in hepatocellular carcinoma cells

(2014) Wen-Lung Ma et al.   CANCER LETTERS

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice

(2014) Roman L. Bogorad et al.   Nature Communications

MUC15 Inhibits Dimerization of EGFR and PI3K–AKT Signaling and Is Associated With Aggressive Hepatocellular Carcinomas in Patients

(2013) Ruo–Yu Wang et al.   GASTROENTEROLOGY

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail

(2012) Ralph Thomas Böttcher et al.   NATURE CELL BIOLOGY

Automated 3D structure composition for large RNAs

(2012) Mariusz Popenda et al.   NUCLEIC ACIDS RESEARCH

Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy

(2011) Yanfen Liu et al.   CELL RESEARCH

Visualizing Proteins and Macromolecular Complexes by Negative Stain EM: from Grid Preparation to Image Acquisition

(2011) David S. Booth et al.   Jove-Journal of Visualized Experiments

Ubiquitination of α5β1 Integrin Controls Fibroblast Migration through Lysosomal Degradation of Fibronectin-Integrin Complexes

(2010) Viola Hélène Lobert et al.   DEVELOPMENTAL CELL

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

Collective cell migration in morphogenesis, regeneration and cancer

(2009) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY