Engineering, delivery, and biological validation of artificial microRNA clusters for gene therapy applications

The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma

(2019) Vivek Bhaskaran et al.   Nature Communications

Analysis of microRNA and Gene Expression Profiles in Alzheimer’s Disease: A Meta-Analysis Approach

(2018) Shirin Moradifard et al.   Scientific Reports

Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

(2018) Thomas Treiber et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Unicellular Origin of the Animal MicroRNA Machinery

(2018) Jon Bråte et al.   CURRENT BIOLOGY

Engineering Artificial MicroRNAs for Multiplex Gene Silencing and Simplified Transgenic Screen

(2018) Nannan Zhang et al.   PLANT PHYSIOLOGY

Gene synthesis allows biologists to source genes from farther away in the tree of life

(2018) Aditya M. Kunjapur et al.   Nature Communications

Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study

(2017) Nico van Zandwijk et al.   LANCET ONCOLOGY

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors

(2016) Muhammad S. Beg et al.   INVESTIGATIONAL NEW DRUGS

Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder

(2016) Ye E Wu et al.   NATURE NEUROSCIENCE

Construction and Characterization of a Synthetic MicroRNA Cluster for Multiplex RNA Interference in Mammalian Cells

(2015) Tingting Wang et al.   ACS Synthetic Biology

Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA- and protein-based antiangiogenic factors

(2015) Anne Louise Askou et al.   Molecular Therapy-Methods & Clinical Development

Kaplan–Meier curves for survivor causal effects with time-to-event outcomes

(2013) Yasutaka Chiba   Clinical Trials

Preclinical Evaluation of An Anti-HCV miRNA Cluster for Treatment of HCV Infection

(2013) Xiao Yang et al.   MOLECULAR THERAPY

The miR-302-367 cluster as a potential stemness regulator in ESCs

(2011) Alicia Barroso-del Jesus et al.   CELL CYCLE

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Expression of Multiple Artificial MicroRNAs from a Chicken miRNA126-Based Lentiviral Vector

(2011) Steve C.-Y. Chen et al.   PLoS One

Causes and consequences of microRNA dysregulation in cancer

(2009) Carlo M. Croce   NATURE REVIEWS GENETICS

The CMV early enhancer/chicken β actin (CAG) promoter can be used to drive transgene expression during the differentiation of murine embryonic stem cells into vascular progenitors

(2008) Annika N Alexopoulou et al.   BMC CELL BIOLOGY

Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron

(2008) Ying Poi Liu et al.   NUCLEIC ACIDS RESEARCH