Increasing brain palmitoylation rescues behavior and neuropathology in Huntington disease mice

Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease

(2020) Xiaochao Wei et al.   CIRCULATION RESEARCH

Huntington’s disease alters human neurodevelopment

(2020) Monia Barnat et al.   SCIENCE

Dynamic Palmitoylation of the Sodium-Calcium Exchanger Modulates Its Structure, Affinity for Lipid-Ordered Domains, and Inhibition by XIP

(2020) Caglar Gök et al.   Cell Reports

Upregulation of Cellular Palmitoylation Mitigates α‐Synuclein Accumulation and Neurotoxicity

(2020) Gary P.H. Ho et al.   MOVEMENT DISORDERS

CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis

(2020) Jian-Wei Hao et al.   Nature Communications

Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network

(2019) Simona Gribaudo et al.   Stem Cell Reports

Identifying the potential substrates of the depalmitoylation enzyme Acyl-protein thioesterase 1

(2019) Huicong Liu et al.   CURRENT MOLECULAR MEDICINE

Axonal transport and neurological disease

(2019) James N. Sleigh et al.   Nature Reviews Neurology

Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington’s Disease

(2018) Amandine Virlogeux et al.   Cell Reports

High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration

(2018) Ismael Al-Ramahi et al.   Cell Systems

Neuronal network maturation differently affects secretory vesicles and mitochondria transport in axons

(2018) Eve Moutaux et al.   Scientific Reports

Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice

(2016) Peter Langfelder et al.   NATURE NEUROSCIENCE

Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease

(2016) Eduardo E. Arteaga-Bracho et al.   NEUROBIOLOGY OF DISEASE

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

HIPPIE v2.0: enhancing meaningfulness and reliability of protein–protein interaction networks

(2016) Gregorio Alanis-Lobato et al.   NUCLEIC ACIDS RESEARCH

Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington’s disease

(2016) Aldrin E. Molero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease

(2016) Xing Guo et al.   Nature Communications

Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport

(2016) María-Victoria Hinckelmann et al.   Nature Communications

Huntingtin functions as a scaffold for selective macroautophagy

(2015) Yan-Ning Rui et al.   NATURE CELL BIOLOGY

A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease

(2015) Kristina Bečanović et al.   NATURE NEUROSCIENCE

ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization

(2015) David Tse Shen Lin et al.   eLife

The Autodepalmitoylating Activity of APT Maintains the Spatial Organization of Palmitoylated Membrane Proteins

(2014) Nachiket Vartak et al.   BIOPHYSICAL JOURNAL

Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane

(2014) H. Brandstaetter et al.   Disease Models & Mechanisms

Neurotrophin receptor p75NTR mediates Huntington’s disease–associated synaptic and memory dysfunction

(2014) Verónica Brito et al.   JOURNAL OF CLINICAL INVESTIGATION

The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation

(2014) Y. C. Wong et al.   JOURNAL OF NEUROSCIENCE

Potential function for the Huntingtin protein as a scaffold for selective autophagy

(2014) Joseph Ochaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

(2013) Diana Zala et al.   CELL

COPII — a flexible vesicle formation system

(2013) Elizabeth A Miller et al.   CURRENT OPINION IN CELL BIOLOGY

Mutant Huntingtin Alters Retrograde Transport of TrkB Receptors in Striatal Dendrites

(2013) G. Liot et al.   JOURNAL OF NEUROSCIENCE

Huntingtin Acts Non Cell-Autonomously on Hippocampal Neurogenesis and Controls Anxiety-Related Behaviors in Adult Mouse

(2013) Patrick Pla et al.   PLoS One

Embryonic stem cells neural differentiation qualifies the role of Wnt/β-Catenin signals in human telencephalic specification and regionalization

(2013) Camille Nicoleau et al.   STEM CELLS

Releasing the brake: restoring fast axonal transport in neurodegenerative disorders

(2013) Maria-Victoria Hinckelmann et al.   TRENDS IN CELL BIOLOGY

Confirming Target Engagement for Reversible Inhibitors in Vivo by Kinetically Tuned Activity-Based Probes

(2012) Alexander Adibekian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

Synchronization of secretory protein traffic in populations of cells

(2012) Gaelle Boncompain et al.   NATURE METHODS

Altered palmitoylation and neuropathological deficits in mice lacking HIP14

(2011) R. R. Singaraja et al.   HUMAN MOLECULAR GENETICS

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis

(2010) Sarah J Tabrizi et al.   LANCET NEUROLOGY

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking

(2010) Raúl Pardo et al.   Molecular Brain

Mutant Huntingtin Impairs Post-Golgi Trafficking to Lysosomes by Delocalizing Optineurin/Rab8 Complex from the Golgi Apparatus

(2009) Daniel del Toro et al.   MOLECULAR BIOLOGY OF THE CELL

A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

(2009) Gabriele Siegel et al.   NATURE CELL BIOLOGY

Altered white matter microstructure in the corpus callosum in Huntington's disease: Implications for cortical “disconnection”

(2009) H. Diana Rosas et al.   NEUROIMAGE

Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression

(2008) ÁT Behan et al.   MOLECULAR PSYCHIATRY