4.3 Article

A Comprehensive, Flexible Collection of SARS-CoV-2 Coding Regions

Journal

G3-GENES GENOMES GENETICS
Volume 10, Issue 9, Pages 3399-3402

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1534/g3.120.401554

Keywords

SARS-CoV-2; coding sequence collection; Gateway-compatible; TEV (tobacco etch virus) sequence

Funding

  1. Canadian Institutes for Health Research Foundation
  2. Canada Excellence Research Chairs Program
  3. Thistledown Foundation
  4. LabEx Integrative Biology of Emerging Infectious Diseases [10-LABX-0062]
  5. Platform for European Preparedness Against (Re-)emerging Epidemics, EU [602525]

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The world is facing a global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.

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