Article
Nutrition & Dietetics
Murat Ozan, Yusuf Buzdagli, Cemre Didem Eyipinar, Nurcan Kilic Baygutalp, Neslihan Yuce, Furkan Oget, Emirhan Kan, Fatih Baygutalp
Summary: The study demonstrated that the combined intake of caffeine and taurine significantly improved physical performance in elite male boxers compared to placebo. Additionally, taurine alone also showed significant improvements in peak power compared to the caffeine group. Furthermore, the combined intake of caffeine and taurine had positive effects on balance, agility, and cognitive function in the athletes.
Article
Cell Biology
Wei Wang, Yuqing Xiong, Haomiao Zhao, Rongli Xu
Summary: This study found that CircEXOC5 was upregulated in the lung tissues of septic ALI. Silencing CircEXOC5 inhibited cell pyroptosis and the release of inflammatory cytokines in LPS-stimulated MPVEC cells. The study also found that CircEXOC5 suppressed Nrf2 expression in MPVEC cells by recruiting EZH2.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Liying Zou, Qing Yu, Luyun Zhang, Xiu Yuan, Fang Fang, Feng Xu
Summary: Through experiments and analyses, potential regulators in septic acute lung injury were identified, including the long non-coding RNA Gm33647, as well as other lncRNAs and mRNAs related to inflammation.
Article
Immunology
Ruifeng Bai, Jianqiu Pei, Shengqiang Pei, Xiangfeng Cong, Jerold Chun, Fang Wang, Xi Chen
Summary: The study found that the expression of atypical protein kinase C-iota (aPKC-ι) was increased in septic acute lung injury (ALI). In a mouse model, the absence of aPKC-ι led to worsened ALI, while regulating the activation of aPKC-ι through the agonist DBIBB can alleviate the damage of ALI.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Bernhard Aigner, Christian Heumann
Summary: The use of mice as animal models in biomedical research allows for standardization, but there is still significant variability in blood parameters, immunological parameters, and behavioral tests. This variability may be influenced by complex interactions between genotype, environment, and experiment.
Article
Multidisciplinary Sciences
Yuya Kondo, Saori Abe, Hirofumi Toko, Tomoya Hirota, Hiroyuki Takahashi, Masaru Shimizu, Hisashi Noma, Hiroto Tsuboi, Isao Matsumoto, Toshiro Inaba, Takayuki Sumida
Summary: The aim of this study was to investigate the impact of climatic environment on the immunological features of rheumatoid arthritis (RA). Blood samples were collected from RA patients and healthy controls residing in two different locations with varying altitude, average air temperature, and atmospheric pressure. The analysis revealed significant differences in T and B cell subpopulations between the two sites. These findings suggest that climatic environment may influence immune cell proportions and functions, potentially contributing to the pathogenesis of RA.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Analytical
Weizhu Chen, Wenhui Jin, Hua Fang, Hui Chen, Xiaoying Chen, Yiping Zhang, Zhuan Hong
Summary: This paper describes the development of a taurine purity certified reference material (CRM) based on ISO principles. The CRM was characterized using mass balance and quantitative nuclear magnetic resonance spectroscopy. The results showed that the CRM had sufficient homogeneity and remained stable under certain conditions. It can validate analytical measurements in laboratories to ensure accuracy, traceability, reliability, and comparability of results.
MICROCHEMICAL JOURNAL
(2022)
Review
Critical Care Medicine
Xavier Monnet, Christopher Lai, Jean-Louis Teboul
Summary: During septic shock, personalized fluid therapy based on patient characteristics and clinical situation is suggested. Different tests and assessments are recommended for fluid volume expansion and the detection of fluid accumulation. The choice of fluid type and the consideration of potential hypovolemia induced by fluid losses are important factors to consider. Preload responsiveness should be assessed after initial fluid infusion, and different tests can be used depending on the patient's ventilation status and monitoring capabilities. Assessment of fluid accumulation should take into account the specific clinical conditions of the patient. Fluid removal in the de-escalation phase can be guided by preload responsiveness testing.
Article
Critical Care Medicine
Imane Adda, Christopher Lai, Jean-Louis Teboul, Laurent Guerin, Francesco Gavelli, Xavier Monnet
Summary: Norepinephrine enhances the Pms increase induced by PLR in septic shock patients. The study results suggest that a bolus of fluid of the same volume has a greater hemodynamic effect at a high dose than at a low dose of norepinephrine.
Article
Food Science & Technology
Guixiang Qin, Sunbang Yi
Summary: The aim of this study was to assess the potential effects of genkwanin (GKA) in septic lung injury and its related mechanisms. An animal model of cecal ligation and puncture (CLP)-induced acute lung injury was constructed. The results showed that GKA reduced lung edema and inflammation in CLP mice and improved inflammatory injury by regulating the NF-κB signaling pathway. These findings suggest that GKA could be a promising drug for the treatment of sepsis-induced acute lung injury.
QUALITY ASSURANCE AND SAFETY OF CROPS & FOODS
(2022)
Article
Endocrinology & Metabolism
Jia Wang, Yuanyuan Wang, Wei Zheng, Xianxian Yuan, Cheng Liu, Ya Zhang, Wei Song, Xiaoxin Wang, Shengnan Liang, Xu Ma, Guanghui Li
Summary: This study aimed to observe the dynamic changes of serum taurine during pregnancy and investigate its relationship with gestational diabetes mellitus (GDM) in early pregnancy. The results showed that low serum taurine concentration in the first trimester was significantly associated with the development of GDM, but the association disappeared as the pregnancy progressed. This may be related to the inhibition of taurine transporter (TauT) activity by high glucose.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Jiali Li, Zihang Zeng, Qiuji Wu, Jiarui Chen, Xingyu Liu, Jianguo Zhang, Yuan Luo, Wenjie Sun, Zhengrong Huang, Junhong Zhang, Yan Gong, Conghua Xie
Summary: The review summarizes the imbalance of Th1 and Th2 cells in the tumorigenic microenvironment and the impact of IR on Th1/Th2 polarization, discussing the role in post-radiotherapy complications and highlighting that high-dose IR promotes a shift towards Th2, leading to an immunosuppressive cytokine network.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Review
Immunology
Kari Ann Shirey, Jorge C. G. Blanco, Stefanie N. Vogel
Summary: Respiratory viral infections, such as influenza, can lead to severe consequences due to misalignments between circulating strains and predicted vaccine strains. In addition to traditional antiviral treatments, blocking the host's immune response may offer a more effective approach to combat these infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Seong Hoon Kim, Hye-Won Yum, Seung Hyeon Kim, Su-Jung Kim, Kyeojin Kim, Chaekyun Kim, Young-Ger Suh, Young-Joon Surh
Summary: Taurine chloramine (TauCl) can effectively protect the skin from photodamage by reducing oxidative damage, apoptotic cell death, and inflammation. This protective effect is associated with inhibition of STAT3 activation and induction of antioxidant enzymes.
Article
Chemistry, Multidisciplinary
Apurva Panjla, Irfan Qayoom, Ashok Kumar, Sandeep Verma
Summary: The novel diketopiperazine (DT) designed and synthesized in this study induces osteoblastic differentiation of pre-osteoblasts and bone-marrow-derived stem cells in vitro, enhancing the osteogenic potential of cryogel matrix. These functional diketopiperazines have potential as scaffolds for bone healing and regeneration.
CHEMICAL COMMUNICATIONS
(2021)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)