Combating COVID-19: The role of drug repurposing and medicinal plants

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Potential interventions for novel coronavirus in China: A systematic review

(2020) Lei Zhang et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

First Case of 2019 Novel Coronavirus in the United States

(2020) Michelle L. Holshue et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

(2020) Xintian Xu et al.   Science China-Life Sciences

Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies

(2020) Syed Faraz Ahmed et al.   Viruses-Basel

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

(2020) Timothy P. Sheahan et al.   Nature Communications

Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial

(2020) Jesús Villar et al.   Lancet Respiratory Medicine

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

(2020) Xueting Yao et al.   CLINICAL INFECTIOUS DISEASES

SARS CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and Other Drugs for the Treatment of the New Coronavirus

(2020) Michele Costanzo et al.   CURRENT MEDICINAL CHEMISTRY

New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

(2020) Christian A. Devaux et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Aminoquinolines against coronavirus disease 2019 (COVID-19): chloroquine or hydroxychloroquine

(2020) Zahra Sahraei et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression

(2020) Dan Zhou et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Potential inhibitors of coronavirus 3-chymotrypsin-like protease (3CLpro): an in silico screening of alkaloids and terpenoids from African medicinal plants

(2020) Gideon A. Gyebi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Molecular Docking, Simulation and MM-PBSA Studies of Nigella Sativa Compounds: A Computational Quest to identify Potential Natural Antiviral for COVID-19 Treatment

(2020) Sajjad Ahmad et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

In silico study the inhibition of angiotensin converting enzyme 2 receptor of COVID-19 by Ammoides verticillata components harvested from Western Algeria

(2020) Imane Abdelli et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach

(2020) Sukanth Kumar Enmozhi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Drug repurposing against COVID-19: focus on anticancer agents

(2020) Gennaro Ciliberto et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study

(2020) Lisi Deng et al.   JOURNAL OF INFECTION

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Are certain drugs associated with enhanced mortality in COVID-19?

(2020) M R Goldstein et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

Can complementary and alternative medicines be beneficial in the treatment of COVID-19 through improving immune system function?

(2020) Mehrbakhsh Nilashi et al.   Journal of Infection and Public Health

Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants

(2020) Muhammad Tahir ul Qamar et al.   Journal of Pharmaceutical Analysis

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

(2020) Leon Caly et al.   ANTIVIRAL RESEARCH

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

(2020) Ka-Tim Choy et al.   ANTIVIRAL RESEARCH

Potential benefits of combination of Nigella sativa and Zn supplements to treat COVID-19

(2020) Mohammad Tariqur Rahman   Journal of Herbal Medicine

Antiviral potential of curcumin

(2018) Dony Mathew et al.   Journal of Functional Foods

SELECTIVE INHIBITION OF HEPATITIS C VIRUS REPLICATION BY ALPHA-ZAM, A Nigella sativa SEED FORMULATION

(2016) Olufunmilayo G. Oyero et al.   African Journal of Traditional Complementary and Alternative Medicines

Broad-spectrum antiviral properties of andrographolide

(2016) Swati Gupta et al.   ARCHIVES OF VIROLOGY

A review of treatment modalities for Middle East Respiratory Syndrome

(2016) Yin Mo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A review on antiviral activity of the Himalayan medicinal plants traditionally used to treat bronchitis and related symptoms

(2016) Rahila Amber et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Can you teach old drugs new tricks?

(2016) Nicola Nosengo   NATURE

Synergistic effects of thymoquinone and curcumin on immune response and anti-viral activity against avian influenza virus (H9N2) in turkeys

(2016) S. Umar et al.   POULTRY SCIENCE

Curcumin inhibits HIV-1 by promoting Tat protein degradation

(2016) Amjad Ali et al.   Scientific Reports

Promising Anti-influenza Properties of Active Constituent of Withania somnifera Ayurvedic Herb in Targeting Neuraminidase of H1N1 Influenza: Computational Study

(2015) Zhi Cai et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry

(2015) Wenjiao Wu et al.   Viruses-Basel

Autophagy Activation and Antiviral Activity by a Licorice Triterpene

(2014) Samuela Laconi et al.   PHYTOTHERAPY RESEARCH

Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS

(2013) Jan Felix Drexler et al.   ANTIVIRAL RESEARCH

Antiviral Activity of Glycyrrhizin against Hepatitis C Virus In Vitro

(2013) Yoshihiro Matsumoto et al.   PLoS One

Effects ofNigella sativaon outcome of hepatitis C in Egypt

(2013) Eman Mahmoud Fathy Barakat   WORLD JOURNAL OF GASTROENTEROLOGY

EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo

(2012) Linda L. Theisen et al.   ANTIVIRAL RESEARCH

Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13

(2012) Mi-Sun Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel antiviral activity of baicalein against dengue virus

(2012) Keivan Zandi et al.   BMC Complementary and Alternative Medicine

HMGB1 Protein Binds to Influenza Virus Nucleoprotein and Promotes Viral Replication

(2012) D. Moisy et al.   JOURNAL OF VIROLOGY

Inhibition of Angiotensin-Converting Enzyme Activity by Flavonoids: Structure-Activity Relationship Studies

(2012) Ligia Guerrero et al.   PLoS One

Glycyrrhizin as antiviral agent against Hepatitis C Virus

(2011) Usman A Ashfaq et al.   Journal of Translational Medicine

Membranotropic Effects of Arbidol, a Broad Anti-Viral Molecule, on Phospholipid Model Membranes

(2010) José Villalaín   JOURNAL OF PHYSICAL CHEMISTRY B

Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway

(2009) KyeongJin Kim et al.   FEBS LETTERS

Curcumin inhibits influenza virus infection and haemagglutination activity

(2009) Da-Yuan Chen et al.   FOOD CHEMISTRY