PNOC Expressed by B Cells in Cholangiocarcinoma Was Survival Related and LAIR2 Could Be a T Cell Exhaustion Biomarker in Tumor Microenvironment: Characterization of Immune Microenvironment Combining Single-Cell and Bulk Sequencing Technology

scTPA: A web tool for single-cell transcriptome analysis of pathway activation signatures

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Helicid reverses lipopolysaccharide‐induced inflammation and promotes GDNF levels in C6 glioma cells through modulation of prepronociceptin

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Single-cell RNA sequencing reveals the tumor microenvironment and facilitates strategic choices to circumvent treatment failure in a chemorefractory bladder cancer patient

(2020) Hye Won Lee et al.   Genome Medicine

Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels tumour heterogeneity plus M2-like tumour-associated macrophage infiltration and aggressiveness in TNBC

(2020) Xuanwen Bao et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma

(2020) Min Zhang et al.   JOURNAL OF HEPATOLOGY

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion

(2020) David H. Peng et al.   Nature Communications

Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation

(2020) Tiago Carvalheiro et al.   Frontiers in Immunology

Establishment of a Colorectal Cancer-Related MicroRNA-mRNA Regulatory Network by Microarray and Bioinformatics

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Benchmarking algorithms for pathway activity transformation of single-cell RNA-seq data

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Editorial: The Role of Inhibitory Receptors in Inflammation and Cancer

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Programmed cell death ligand 1 (PD-L1, CD274) in cholangiocarcinoma – correlation with clinicopathological data and comparison of antibodies

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The immune milieu of cholangiocarcinoma: From molecular pathogenesis to precision medicine

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Biologics, Immunotherapy, and Future Directions in the Treatment of Advanced Cholangiocarcinoma

(2019) Anwaar Saeed et al.   Clinical Colorectal Cancer

TISIDB: an integrated repository portal for tumor-immune system interactions

(2019) Beibei Ru et al.   BIOINFORMATICS

Comprehensive Integration of Single-Cell Data

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Identification of key genes related to high-risk gastrointestinal stromal tumors using bioinformatics analysis

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Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets

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Screening the full leukocyte receptor complex (LRC) region revealed associations with pemphigus that might be explained by gene regulation

(2018) Ticiana Della Justina Farias et al.   IMMUNOLOGY

Single sample scoring of molecular phenotypes

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Successful response to the combination of immunotherapy and chemotherapy in cholangiocarcinoma with high tumour mutational burden and PD-L1 expression: a case report

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Characterisation of the immune-related transcriptome in resected biliary tract cancers

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The Reactome Pathway Knowledgebase

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GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

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PD-L1 expression in perihilar and intrahepatic cholangiocarcinoma

(2017) Jacqueline Fontugne et al.   Oncotarget

Systemic and Adjuvant Therapies for Intrahepatic Cholangiocarcinoma

(2017) Yun Shin Chun et al.   Cancer Control

Genomic Profiling of Biliary Tract Cancers and Implications for Clinical Practice

(2016) Apurva Jain et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Variants of opioid system genes are associated with non-dependent opioid use and heroin dependence

(2016) Matthew Randesi et al.   DRUG AND ALCOHOL DEPENDENCE

Repeated nicotine exposure modulates prodynorphin and pronociceptin levels in the reward pathway

(2016) Lucia Carboni et al.   DRUG AND ALCOHOL DEPENDENCE

Gene-Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-Based Microarray Analysis

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PD-L1 and HLA Class I Antigen Expression and Clinical Course of the Disease in Intrahepatic Cholangiocarcinoma

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Differential gene expression levels might explain association of LAIR2 polymorphisms with pemphigus

(2015) Carolina Maciel Camargo et al.   HUMAN GENETICS

Delta opioid agonists: a concise update on potential therapeutic applications

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(2015) Aaron M Newman et al.   NATURE METHODS

Review The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge

(2015) Katarzyna Tomczak et al.   Wspolczesna Onkologia-Contemporary Oncology

The Soluble Leukocyte-Associated Ig-Like Receptor (LAIR)-2 Antagonizes the Collagen/LAIR-1 Inhibitory Immune Interaction

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Integrative Molecular Analysis of Intrahepatic Cholangiocarcinoma Reveals 2 Classes That Have Different Outcomes

(2013) Daniela Sia et al.   GASTROENTEROLOGY

Inhibition of the Classical and Lectin Pathway of the Complement System by Recombinant LAIR-2

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Serum LAIR-2 Is Increased in Autoimmune Thyroid Diseases

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Inflammatory Mediators Influence the Expression of Nociceptin and Its Receptor in Human Whole Blood Cultures

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Pediatric brainstem gangliogliomas show overexpression of neuropeptide prepronociceptin (PNOC) by microarray and immunohistochemistry

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Enhanced secretion of leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) and soluble LAIR-1 in rheumatoid arthritis: LAIR-2 is a more efficient antagonist of the LAIR-1-collagen inhibitory interaction than is soluble LAIR-1

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Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors

(2011) Jesper B. Andersen et al.   GASTROENTEROLOGY

Efficient Inhibition of Collagen-Induced Platelet Activation and Adhesion by LAIR-2, a Soluble Ig-Like Receptor Family Member

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Expression of pronociceptin and its receptor is downregulated in the brain of human alcoholics

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(2009) Linde Meyaard   IMMUNOLOGY LETTERS

Identification of multiple potent binding sites for human leukocyte associated Ig-like receptor LAIR on collagens II and III

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(2009) Da Wei Huang et al.   Nature Protocols

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