Article
Obstetrics & Gynecology
Dominique Bulgin, Stephen W. W. Patrick, Tamarra McElroy, Elizabeth McNeer, William D. D. Dupont, Velma McBride Murry
Summary: This study aims to examine the factors that affect access to treatment for women with opioid use disorder, including race and ethnicity, community characteristics, and pregnancy status. The analysis of secondary data from a simulated patient caller study in 10 U.S. states reveals that community race and ethnicity distribution and clinic type are associated with the likelihood of securing an appointment for treatment.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sarah D. Lichenstein, Dustin Scheinost, Marc N. Potenza, Kathleen M. Carroll, Sarah W. Yip
Summary: The study identified an opioid abstinence network characterized by specific brain connections associated with substance use treatment response. These findings could lead to the development of personalized treatment approaches and predicting treatment outcomes. The anatomical substrates of opioid vs. cocaine abstinence were found to be distinct, suggesting the potential for novel opioid-specific treatment approaches in combating the opioid epidemic.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Wen-Long Hu, Meng-Chang Tsai, Chun-En Kuo, Chun-Ting Liu, Szu-Ying Wu, Tzu-Chan Wu, Yu-Chiang Hung
Summary: This study investigated the effects of adjuvant laser meridian massage (LMM) in men with opioid use disorder (OUD) undergoing methadone maintenance treatment (MMT). The results showed that LMM significantly reduced heroin use and improved physical health in the experimental group.
BIOMEDICAL JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Gary B. Kaplan, Benjamin L. Thompson
Summary: Opioid use disorder is characterized by excessive use of opioids, inability to control use, withdrawal syndrome, and likelihood of relapse. The opponent process view of motivation suggests that opioid addiction involves positive affective experiences during active involvement and negative affective experiences during abstinence. These negative experiences are hypothesized to be caused by neuroadaptations in the extended amygdala, which includes the CeA, BNST, and NAc shell, as well as input from the BLA. Animal models of opioid withdrawal demonstrate the somatic, motivational, affective, and learning related aspects of withdrawal. Neuroadaptations in the extended amygdala lead to aversive and fear-related effects, hypodopaminergia, and increased vulnerability to relapse. Understanding and reversing these neuroadaptations could lead to new interventions for opioid use disorder.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Substance Abuse
Juliana I. Byanyima, Xinyi Li, Sianneh A. Vesslee, Henry R. Kranzler, Zhenhao Shi, Corinde E. Wiers
Summary: Opioid use disorder (OUD) is a chronic condition with serious adverse consequences, including high incarceration rates and overdose-related fatalities. Medications used for OUD treatment have been shown to cause metabolic impairments, but the effects vary depending on the individual's metabolic condition. Further research is needed to determine the best approach for reducing the risk of metabolic disorders in OUD treatment.
CURRENT ADDICTION REPORTS
(2023)
Article
Biology
Sandra Cole, Stephen Wirkus
Summary: Opioid use disorder is a serious health issue in the USA, leading to addiction, disability, or overdose death. A mathematical model is proposed to predict the development of heroin use disorder in the population, highlighting the importance of specialty treatment facilities.
BULLETIN OF MATHEMATICAL BIOLOGY
(2022)
Article
Psychiatry
Bradley Watts, Daniel J. Gottlieb, Natalie B. Riblet, Jiang Gui, Brian Shiner
Summary: Medication treatment for opioid use disorder (MOUD) has been shown to significantly reduce the risk of suicide mortality as well as external causes of mortality and all-cause mortality.
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Article
Neurosciences
Joshua G. Berenbaum, Prianca A. Nadkarni, Cherie L. Marvel
Summary: This study used functional magnetic resonance imaging to examine the neural mechanisms involved in working memory in opioid-dependent individuals. The results showed that the opioid-dependent group had slower response time and differences in brain activity compared to the healthy controls. Understanding these neural differences can shed light on the impact of substance use on the brain and cognition, potentially leading to new therapeutic targets for substance use disorder.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Tsuo-Cheng Lu, Chun-En Kuo, Szu-Ying Wu, Yi-Hsun Tsai, Yu-Chiang Hung, Wen-Long Hu, Meng-Chang Tsai
Summary: This study aims to investigate the effect of adjuvant light needle therapy in patients with opioid use disorder on methadone maintenance treatment. 100 participants will be enrolled and randomly assigned to an experimental or control group. Treatment effects will be evaluated through assessments of urinary morphine levels, self-reporting of heroin use, quality of life, and pulse diagnosis.
Review
Pharmacology & Pharmacy
Giorgia Caspani, Viktoria Sebok, Nowshin Sultana, Jonathan R. Swann, Alexis Bailey
Summary: Metabolomics can elucidate the biochemical impact of substance abuse, understand the addiction cycle, and predict prognosis for recovery or relapse.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Chieh-Liang Huang, Ping-Ho Chen, Hsien-Yuan Lane, Ing-Kang Ho, Chia-Min Chung
Summary: This study aimed to identify heroin addicts with specific genetic variants in their dopaminergic reward systems and found multiple genes associated with heroin use and craving scores. The results showed a dose-response relationship between the number of genetic risk alleles and heroin craving scores, suggesting potential implications for predicting relapse risk and developing targeted therapies for heroin addiction.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Teddy G. Goetz, Jill B. Becker, Carolyn M. Mazure
Summary: Amidst the coronavirus pandemic, the ongoing opioid epidemic in the United States, fueled by the widespread prescribing of opioids in the 1990s, continues to be a significant issue. Women, who experience more acute and chronic pain, have been prescribed opioids in higher numbers than men, thus leading to misuse and addiction. Efforts to reduce the availability of prescription opioids have unintentionally driven individuals to other synthetic opioids like heroin and fentanyl, prolonging the public health crisis of opioid addiction. Understanding gender differences in opioid use and its effects is crucial for developing effective treatment approaches and public health policies.
Review
Pharmacology & Pharmacy
Dan-Ni Cao, Fei Li, Ning Wu, Jin Li
Summary: Opioid use disorder is a global societal problem and public health burden. Current medications, such as methadone, buprenorphine, and naltrexone, have limitations in terms of abuse liability and compliance. Therefore, there is an urgent need to develop more effective medications with lower abuse potential and better compliance. Recent research progress has identified potential treatment targets and strategies, providing insights for future medication development.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Alison Lynch, Stephan Arndt, Laura Acion
Summary: The number of older adults entering treatment for OUD-H has nearly tripled in the past decade. Late-onset heroin users are more likely to be white, female, educated, and rural, with different referral sources compared to early-onset users.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Medicine, General & Internal
James Wilton, Younathan Abdia, Mei Chong, Mohammad Ehsanul Karim, Stanley Wong, Aaron MacInnes, Rob Balshaw, Bin Zhao, Tara Gomes, Amanda Yu, Maria Alvarez, Richard C. Dart, Mel Krajden, Jane A. Buxton, Naveed Z. Janjua, Roy Purssell
Summary: This study assessed the risk of initiating injection drug use associated with long term prescription opioid treatment and found that individuals with chronic opioid use had a higher risk of IDU initiation compared to other groups.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Statistics & Probability
Camila Epprecht, Dominique Guegan, Alvaro Veiga, Joel Correa da Rosa
Summary: This article compares two approaches of model selection methods for linear regression models: the classical approach Autometrics and the statistical learning methods LASSO and adaLASSO. Through simulation experiments and application with genomic data, the performance of these methods under different scenarios are evaluated.
COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION
(2021)
Article
Pharmacology & Pharmacy
Matthew Randesi, Orna Levran, Wim van den Brink, Peter Blanken, Jan M. van Ree, Jurg Ott, Mary J. Kreek
Article
Hematology
Moonjung Jung, Parinda A. Mehta, Caroline S. Jiang, Rasim O. Rosti, Gabriel Usleaman, Joel M. Correa da Rosa, Francis P. Lach, Erica Goodridge, Arleen D. Auerbach, Stella M. Davies, Agata Smogorzewska, Farid Boulad
Summary: Among siblings with Fanconi anaemia, there is significant correlation in hematological progression, while constitutional abnormalities do not show strong concordance except for kidney abnormalities and microcephaly.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Biochemical Research Methods
Daniel S. Gareau, James Browning, Joel Correa Da Rosa, Mayte Suarez-Farinas, Samantha Lish, Amanda M. Zong, Benjamin Firester, Charles Vrattos, Yael Renert-Yuval, Mauricio Gamboa, Maria G. Vallone, Zamira F. Barragan-Estudillo, Alejandra L. Tamez-Pena, Javier Montoya, Miriam A. Jesus-Silva, Cristina Carrera, Josep Malvehy, Susana Puig, Ashfaq Marghoob, John A. Carucci, James G. Krueger
JOURNAL OF BIOMEDICAL OPTICS
(2020)
Article
Multidisciplinary Sciences
Stefan Eirefelt, Martin Stahlhut, Naila Svitacheva, Martin A. Carnerup, Joel Mauricio Correa Da Rosa, David Adrian Ewald, Troels T. Marstrand, Mikkel Krogh-Madsen, Georg Dunstl, Kevin Neil Dack, Anna Ollerstam, Hanne Norsgaard
Summary: This study describes a selective non-steroidal glucocorticoid receptor (GR) agonist, LEO 134310, for topical use, which is rapidly deactivated in the blood resulting in low systemic exposure and a higher therapeutic index compared with currently used glucocorticoids. The selectivity of LEO 134310 for GR was confirmed within a panel of nuclear receptors, and topical treatment with LEO 134310 in minipigs did not result in significant epidermal thinning.
SCIENTIFIC REPORTS
(2022)
Article
Dermatology
Yael Renert-Yuval, Joel Correa da Rosa, Sandra Garcet, Ana B. Pavel, Jennifer Bares, Margot Chima, Jason E. Hawkes, Patricia Gilleaudeau, Mary Sullivan-Whalen, Giselle K. Singer, James G. Krueger, Emma Guttman-Yassky
Summary: This study investigated the utility of two different alopecia areata-targeted questionnaires, and found that the Alopecia Areata Symptom Impact Scale (AASIS) correlated strongly with alopecia areata severity and clinical response. Patients with <= 20% scalp hair loss after treatment reported improvement in multiple quality-of-life items, which may guide clinicians and improve the development of future clinical trials.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tu Hu, Tanja Todberg, Daniel Andersen, Niels Banhos Danneskiold-Samsoe, Sofie Boesgaard Neestrup Hansen, Karsten Kristiansen, David Adrian Ewald, Susanne Brix, Joel Correa da Rosa, Ilka Hoof, Lone Skov, Thomas Litman
Summary: This study used BRB-seq technique to analyze the transcriptome of tape-stripped skin samples from atopic dermatitis patients and healthy controls. An AD signature consisting of genes related to skin barrier and inflammatory response was identified. However, the low and highly variable transcript counts in tape-stripped samples were a limiting factor for epidermal transcriptome profiling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Dermatology
Jill I. Olydam, Linde E. M. de Wijs, Willem A. Dik, Mads A. Ropke, Joel Correa Da Rosa, Dirk Jan Hijnen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dermatology
Joseph Han, Scott Stratman, Jade N. Young, Dina Poplausky, Shayan Owji, Yen Luu, Yeriel Estrada, Joel Correa da Rosa, James G. Krueger, Nicholas Gulati
Summary: Diphencyprone (DPCP) causes a delayed-type hypersensitivity reaction when applied topically, and is used clinically for various conditions. In this study, proteomic analysis of healthy volunteers showed upregulation of immune cell activation, tissue remodeling, antineoplastic markers, and Th1 axis markers following DPCP application. Negative regulators of immune function were also upregulated, which may explain the therapeutic benefits in autoimmune conditions. The study also revealed a transient Th2 response followed by Th1 polarization. Overall, DPCP induces a complex and evolving immunological response.
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Tu Hu, Tanja Todberg, David Adrian Ewald, Ilka Hoof, Joel Correa da Rosa, Lone Skov, Thomas Litman
Summary: The skin transcriptome of atopic dermatitis (AD) is stable over time, with the largest variation due to disease, individual, and skin site. AD-specific differentially expressed genes revealed disrupted skin barrier and activated immune response as the main features of AD. Potential novel targets in AD were also identified. This study provides new methods and insights for future skin research.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Substance Abuse
Patty van Benthem, Renske Spijkerman, Peter Blanken, Albert Boon, Robert Vermeiren, Vincent Hendriks
Summary: This study investigated the value of systematic client feedback in youth mental health and addiction care. The results showed that the client feedback intervention did not lead to improved therapeutic alliance or treatment outcomes for the participants.
EUROPEAN ADDICTION RESEARCH
(2023)
Article
Allergy
Paola Facheris, Joel Correa Da Rosa, Angel D. D. Pagan, Michael Angelov, Ester Del Duca, Grace Rabinowitz, Pedro Jesus Gomez Arias, Camille Rothenberg Lausell, Yeriel D. D. Estrada, Swaroop Bose, Mashkura Chowdhury, Avner Shemer, Ana B. B. Pavel, Emma Guttman-Yassky
Summary: The unique characteristics of adult-onset atopic dermatitis (AOAD) compared to pediatric-onset AD persisting into adulthood (POAD) have not been well-studied, hindering the development of targeted therapeutics. This study analyzed skin and blood samples from AOAD, POAD, and healthy controls and found that both AOAD and POAD showed immune and barrier dysregulations with shared Th2/Th22 hyperactivation. POAD had greater inflammation and compromised epidermal barrier compared to AOAD. AOAD also had more dysregulated proteins in serum, including pro-inflammatory and cardiovascular-risk markers.
Article
Biotechnology & Applied Microbiology
Joel Correa da Rosa, Jose O. Aleman, Jason Mohabir, Yupu Liang, Jan L. Breslow, Peter R. Holt
Summary: Obesity is a growing epidemic in the United States, and there is limited understanding of the mechanisms behind weight gain and loss. Integrating omics data has become a popular method to increase understanding of complex phenotypes. The study developed a strategy to screen predictors from a small cohort of obese women, and successfully identified baseline fecal bile acids and regulation in RT-polymerase chain reaction as the most predictive data sources for forecasting weight loss rates.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2022)
Article
Clinical Neurology
Vadim Yuferov, Eduardo R. Butelman, Matthew Randesi, Wim van den Brink, Peter Blanken, Jan M. van Ree, Mary Jeanne Kreek
Summary: The functional SERT promoter tandem repeat genotype may be associated with heavy cocaine exposure and more rapid escalation of cocaine use, in persons with and without opioid dependence diagnosis.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Medicine, Research & Experimental
Christina Pressl, Caroline S. Jiang, Joel Correa da Rosa, Maximilian Friedrich, Roger Vaughan, Winrich A. Freiwald, Jonathan N. Tobin
Summary: The study found a diagnostic rate for prosopagnosia of 0.012% (12 per 100,000 individuals). Elevated frequency of prosopagnosia diagnosis was observed in individuals with certain comorbid conditions such as personality disorder, depression, epilepsy, and anxiety. Furthermore, prosopagnosia diagnoses increased with the number of comorbid conditions.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
