Contribution of Heptose Metabolites and the cag Pathogenicity Island to the Activation of Monocytes/Macrophages by Helicobacter pylori

The HopQ-CEACAM Interaction Controls CagA Translocation, Phosphorylation, and Phagocytosis of Helicobacter pylori in Neutrophils

(2020) Ina-Kristin Behrens et al.   mBio

Helicobacter pylori Avoids the Critical Activation of NLRP3 Inflammasome-Mediated Production of Oncogenic Mature IL-1β in Human Immune Cells

(2020) Suneesh Kumar Pachathundikandi et al.   Cancers

The Transcriptional Network That Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1

(2020) Iveta Gažová et al.   Frontiers in Cell and Developmental Biology

Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection

(2019) Loryn Holokai et al.   PLoS Pathogens

Characterization of Glucose Transporter 6 in Lipopolysaccharide-Induced Bone Marrow–Derived Macrophage Function

(2019) Beth T. Caruana et al.   JOURNAL OF IMMUNOLOGY

OAS1, OAS2 and OAS3 restrict intracellular M. tb replication and enhance cytokine secretion

(2019) Gina Leisching et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Transcriptional characteristics of activated macrophages

(2019) Victor Glanz et al.   CURRENT PHARMACEUTICAL DESIGN

ADP heptose, a novel pathogen-associated molecular pattern identified in Helicobacter pylori

(2019) Lennart Pfannkuch et al.   FASEB JOURNAL

Comparison of human monocyte derived macrophages and THP1-like macrophages as in vitro models for M. tuberculosis infection

(2019) Abhilasha Madhvi et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

The Helicobacter pylori adhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA

(2018) Daniel A Bonsor et al.   EMBO JOURNAL

The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2

(2018) Dimitry A. Chistiakov et al.   IMMUNOBIOLOGY

d-Glycero-β-d-Manno-Heptose 1-Phosphate and d-Glycero-β-d-Manno-Heptose 1,7-Biphosphate Are Both Innate Immune Agonists

(2018) Itunuoluwa A. Adekoya et al.   JOURNAL OF IMMUNOLOGY

Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose

(2018) Ping Zhou et al.   NATURE

Functional expression of TLR5 of different vertebrate species and diversification in intestinal pathogen recognition

(2018) Eugenia Faber et al.   Scientific Reports

GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages

(2018) Shotaro Maedera et al.   FEBS LETTERS

Integrin but not CEACAM receptors are dispensable for Helicobacter pylori CagA translocation

(2018) Qing Zhao et al.   PLoS Pathogens

Molecular dissection of protein-protein interactions between integrin α5β1 and the Helicobacter pylori Cag type IV secretion system

(2017) Thomas Koelblen et al.   FEBS Journal

Helicobacter pylori: A Paradigm Pathogen for Subverting Host Cell Signal Transmission

(2017) Michael Naumann et al.   TRENDS IN MICROBIOLOGY

TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection

(2017) Alevtina Gall et al.   mBio

ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System

(2017) Stephanie Zimmermann et al.   Cell Reports

ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria

(2017) Milica Milivojevic et al.   PLoS Pathogens

Helicobacter pylori modulates host cell responses by CagT4SS-dependent translocation of an intermediate metabolite of LPS inner core heptose biosynthesis

(2017) Saskia C. Stein et al.   PLoS Pathogens

The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus

(2016) Maria E. Lund et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system

(2016) M G Varga et al.   ONCOGENE

TIFA as a crucial mediator for NLRP3 inflammasome

(2016) Ting-Yang Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular and Structural Analysis of the Helicobacter pylori cag Type IV Secretion System Core Complex

(2016) Arwen E. Frick-Cheng et al.   mBio

Macrophages recognize theHelicobacter pyloritype IV secretion system in the absence of toll-like receptor signalling

(2015) Manuel Koch et al.   CELLULAR MICROBIOLOGY

Helicobacter pylori Activates and Expands Lgr5+ Stem Cells Through Direct Colonization of the Gastric Glands

(2015) Michael Sigal et al.   GASTROENTEROLOGY

Activation of NLRP3 inflammasome in human neutrophils by Helicobacter pylori infection

(2015) Erandi Pérez-Figueroa et al.   Innate Immunity

Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity

(2015) R. G. Gaudet et al.   SCIENCE

THP-1 cell line: An in vitro cell model for immune modulation approach

(2014) Wasaporn Chanput et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

TLR9 and NF-κB Are Partially Involved in Activation of Human Neutrophils by Helicobacter pylori and Its Purified DNA

(2014) Lourdes Alvarez-Arellano et al.   PLoS One

Dynamics of Lewis b Binding and Sequence Variation of the babA Adhesin Gene during Chronic Helicobacter pylori Infection in Humans

(2014) Sandra Nell et al.   mBio

Helicobacter pyloriouter membrane protein HopQ identified as a novel T4SS-associated virulence factor

(2013) Elena Belogolova et al.   CELLULAR MICROBIOLOGY

The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production inHelicobacter pyloriinfected dendritic cells

(2013) Dong-Jae Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Helicobacter pylori induces type 4 secretion system-dependent, but CagA-independent activation of IκBs and NF-κB/RelA at early time points

(2013) Olga Sokolova et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Nucleotide Oligomerization Domain 1 Enhances IFN-  Signaling in Gastric Epithelial Cells during Helicobacter pylori Infection and Exacerbates Disease Severity

(2013) C. C. Allison et al.   JOURNAL OF IMMUNOLOGY

Impact of cagPAI and T4SS on the Inflammatory Response of Human Neutrophils to Helicobacter pylori Infection

(2013) Norma Angélica Sánchez-Zauco et al.   PLoS One

A novel NOD1- and CagA-independent pathway of interleukin-8 induction mediated by theHelicobacter pyloritype IV secretion system

(2012) Rebecca J. Gorrell et al.   CELLULAR MICROBIOLOGY

Comparative Analysis of the Interaction of Helicobacter pylori with Human Dendritic Cells, Macrophages, and Monocytes

(2012) Michael Fehlings et al.   INFECTION AND IMMUNITY

In VivoExpression of Helicobacter pylori Virulence Genes in Patients with Gastritis, Ulcer, and Gastric Cancer

(2011) Francisco Avilés-Jiménez et al.   INFECTION AND IMMUNITY

Enhanced M1 Macrophage Polarization in Human Helicobacter pylori-Associated Atrophic Gastritis and in Vaccinated Mice

(2010) Marianne Quiding-Järbrink et al.   PLoS One

A Global Overview of the Genetic and Functional Diversity in the Helicobacter pylori cag Pathogenicity Island

(2010) Patrick Olbermann et al.   PLoS Genetics

Extracellular and Intracellular Pattern Recognition Receptors Cooperate in the Recognition of Helicobacter pylori

(2009) Roland Rad et al.   GASTROENTEROLOGY

SagA of CagA in Helicobacter pylori pathogenesis

(2008) Masanori Hatakeyama   CURRENT OPINION IN MICROBIOLOGY

Protein Subassemblies of the Helicobacter pylori Cag Type IV Secretion System Revealed by Localization and Interaction Studies

(2008) S. Kutter et al.   JOURNAL OF BACTERIOLOGY

STRING 8--a global view on proteins and their functional interactions in 630 organisms

(2008) L. J. Jensen et al.   NUCLEIC ACIDS RESEARCH

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark