Inhibition of Pseudomonas aeruginosa Alginate Synthesis by Ebselen Oxide and Its Analogues

Persistence and Microevolution of Pseudomonas aeruginosa in the Cystic Fibrosis Lung: A Single-Patient Longitudinal Genomic Study

(2019) Irene Bianconi et al.   Frontiers in Microbiology

VX-445–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

(2018) Dominic Keating et al.   NEW ENGLAND JOURNAL OF MEDICINE

VX-659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

(2018) Jane C. Davies et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cystic Fibrosis Gene Therapy: Looking Back, Looking Forward

(2018) Ashley Cooney et al.   Genes

Repurposing antipsychotic drugs into antifungal agents: Synergistic combinations of azoles and bromperidol derivatives in the treatment of various fungal infections

(2017) Selina Y.L. Holbrook et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thermal and Photoinduced Copper-Promoted C–Se Bond Formation: Synthesis of 2-Alkyl-1,2-benzisoselenazol-3(2H)-ones and Evaluation against Mycobacterium tuberculosis

(2017) Sandeep Thanna et al.   JOURNAL OF ORGANIC CHEMISTRY

Safety and efficacy of ebselen for the prevention of noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trial

(2017) Jonathan Kil et al.   LANCET

Versatile modes of cellular regulation via cyclic dinucleotides

(2017) Petya Violinova Krasteva et al.   Nature Chemical Biology

Development of ebsulfur analogues as potent antibacterials against methicillin-resistant Staphylococcus aureus

(2016) Huy X. Ngo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of methionine aminopeptidase 2 as a molecular target of the organoselenium drug ebselen and its derivatives/analogues: Synthesis, inhibitory activity and molecular modeling study

(2016) Ewelina Węglarz-Tomczak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity

(2016) Huy X. Ngo et al.   ChemMedChem

Substituent effects on axial chirality in 1-aryl-3,4-dihydroisoquinolines: controlling the rate of bond rotation

(2016) Josep Mas Roselló et al.   TETRAHEDRON

Dimeric c-di-GMP Is Required for Post-translational Regulation of Alginate Production inPseudomonas aeruginosa

(2015) John C. Whitney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A combination approach to treating fungal infections

(2015) Sanjib K. Shrestha et al.   Scientific Reports

Turnover of strains and intraclonal variation amongst Pseudomonas aeruginosa isolates from paediatric CF patients

(2014) Amanda J. Hall et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Catalytic Mechanism and Mode of Action of the Periplasmic Alginate Epimerase AlgG

(2014) Francis Wolfram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics and associations of microbial community types across the human body

(2014) Tao Ding et al.   NATURE

Mechanism of activation of bacterial cellulose synthase by cyclic di-GMP

(2014) Jacob L W Morgan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Highly efficient synthesis and antioxidant capacity of N-substituted benzisoselenazol-3(2H)-ones

(2014) Agata J. Pacuła et al.   RSC Advances

Coexistence and Within-Host Evolution of Diversified Lineages of Hypermutable Pseudomonas aeruginosa in Long-term Cystic Fibrosis Infections

(2014) Sofía Feliziani et al.   PLoS Genetics

P. aeruginosa SGNH Hydrolase-Like Proteins AlgJ and AlgX Have Similar Topology but Separate and Distinct Roles in Alginate Acetylation

(2014) Perrin Baker et al.   PLoS Pathogens

High-Throughput Screening Using the Differential Radial Capillary Action of Ligand Assay Identifies Ebselen As an Inhibitor of Diguanylate Cyclases

(2013) Ori J. Lieberman et al.   ACS Chemical Biology

Structural and Functional Characterization ofPseudomonas aeruginosaAlgX

(2013) Laura M. Riley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ebsulfur Is a Benzisothiazolone Cytocidal Inhibitor Targeting the Trypanothione Reductase ofTrypanosoma brucei

(2013) Jun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

(2013) U. Romling et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Ivacaftor in Subjects With Cystic Fibrosis Who Are Homozygous for the F508del-CFTR Mutation

(2012) Patrick A. Flume et al.   CHEST

Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione

(2012) Jun Lu et al.   FASEB JOURNAL

Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production inPseudomonas aeruginosa

(2012) John C. Whitney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

A CFTR Potentiator in Patients with Cystic Fibrosis and theG551DMutation

(2011) Bonnie W. Ramsey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions

(2011) K. G. Roelofs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for alginate secretion across the bacterial outer membrane

(2011) John C. Whitney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

(2011) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTRMutation

(2010) Frank J. Accurso et al.   NEW ENGLAND JOURNAL OF MEDICINE

AlgK Is a TPR-Containing Protein and the Periplasmic Component of a Novel Exopolysaccharide Secretin

(2010) Carrie-Lynn Keiski et al.   STRUCTURE

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

(2009) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Annual Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007

(2008) Alicia I. Hidron et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY