Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner

(2014) W. W.-L. Wong et al.   BLOOD

Role of Inflammation-Associated Microenvironment in Tumorigenesis and Metastasis

(2014) Feng Gao et al.   CURRENT CANCER DRUG TARGETS

Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

(2014) K. Newton et al.   SCIENCE

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

(2014) Q Remijsen et al.   Cell Death & Disease

Expedient Synthesis of Highly Potent Antagonists of Inhibitor of Apoptosis Proteins (IAPs) with Unique Selectivity for ML-IAP

(2013) Mitchell Vamos et al.   ACS Chemical Biology

Control of Life-or-Death Decisions by RIP1 Kinase

(2013) Dana E Christofferson et al.   Annual Review of Physiology

The impact of personalized medicine on survival: Comparisons of results in metastatic breast, colorectal and non-small-cell lung cancers

(2013) Antonio Rossi et al.   CANCER TREATMENT REVIEWS

The genetic complexity of common cancers and the promise of personalized medicine: is there any hope?

(2013) Monica Arnedos et al.   JOURNAL OF PATHOLOGY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Evaluating cell lines as tumour models by comparison of genomic profiles

(2013) Silvia Domcke et al.   Nature Communications

Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism

(2012) Jennifer L. Allensworth et al.   BREAST CANCER RESEARCH AND TREATMENT

AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancer

(2012) Melissa K. Brunckhorst et al.   CANCER BIOLOGY & THERAPY

Fra-1 Promotes Breast Cancer Chemosensitivity by Driving Cancer Stem Cells from Dormancy

(2012) D. Lu et al.   CANCER RESEARCH

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Minireview: Animal Models and Mechanisms of Ovarian Cancer Development

(2012) Lisa K. Mullany et al.   ENDOCRINOLOGY

Targeting IAP proteins for therapeutic intervention in cancer

(2012) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL