Article
Chemistry, Multidisciplinary
Jia Li, Leli Zeng, Zheng Wang, Hengxing Chen, Shuo Fang, Jinquan Wang, Chao-Yun Cai, Enming Xing, Xinxing Liao, Zhi-Wei Li, Charles R. Ashby, Zhe-Sheng Chen, Hui Chao, Yihang Pan
Summary: RuZ, a cycloruthenated complex, self-assembles into nanoaggregates in cell culture medium, leading to high intracellular concentrations in multi-drug resistant (MDR) cancer cells. It decreases oxygen consumption, inhibits glycolysis, lowers ATP levels, increases retention in MDR cells, induces oxidative stress and apoptosis. Proteomic analysis shows RuZ decreases glycolysis and mitochondrial respiration proteins while increasing apoptosis-related proteins. It inhibits proliferation of 35 cancer cell lines, including drug-resistant ones, and is effective in doxorubicin-resistant mouse tumor xenografts.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Haoran Wang, Jianhua Wei, Hong Jiang, Ye Zhang, Caina Jiang, Xianli Ma
Summary: The novel metal complexes 6a and 6c exhibit superior antitumor activity compared to cisplatin, inducing DNA damage, G1 cell cycle arrest, and apoptosis to exert their effects.
Article
Biochemistry & Molecular Biology
Guang-Bin Jiang, Wen-Yao Zhang, Miao He, Yi-Ying Gu, Lan Bai, Yang-Jie Wang, Qiao-Yan Yi, Fan Du
Summary: Ruthenium-containing complexes show excellent cytotoxicity against HepG-2 cells, exhibit better antitumor activity than cisplatin, and have no obvious toxicity to normal cells. DNA binding results suggest interaction with DNA, and the complexes induce apoptosis through different pathways.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Yuliang Yang, Xiaofeng Zou, Yanyan Sun, Feihong Chen, Jian Zhao, Shaohua Gou
Summary: This article presents a rational design of half-sandwich Ru(II) complexes for mitochondria-targeted anticancer and antimetastatic agents by introducing the NDI unit into the N,N-chelating ligand of these complexes, which exhibit excellent emission performance. These complexes have potential applications in the design of multifunctional theranostic agents and fluorescent biomarkers.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yuanwei Liang, Weiting Huang, Siqi Wang, Weiming Su, Qianyi Situ, Luxin He
Summary: In this study, a fairly small-sized aryl nitrogen mustard-conjugated terpyridine ligand was synthesized in only two steps to chelate with RuCl3 and form a [Ru(tpy-CM)(2)]Cl-2 complex. This complex showed prominent antiproliferative activity against several tumor cells, particularly human renal clear cell carcinoma cells, by inducing G1 phase cell cycle arrest and apoptosis.
JOURNAL OF CHEMICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Marwa F. Ahmed, Atiah H. Almalki
Summary: New thiosemicarbazone derivatives were synthesized and evaluated for their anticancer activity, with compounds IIIa, IIIe, and IIIh showing promising results. Compound IIIa exhibited potent inhibitory activity against ribonucleotide reductase and induced apoptosis through activating the intrinsic apoptotic pathway.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Ajay Kumar, Bunty Sharma, Ujjawal Sharma, Gaurav Parashar, Nidarshana Chaturvedi Parashar, Isha Rani, Seema Ramniwas, Satwinderjeet Kaur, Shafiul Haque, Hardeep Singh Tuli
Summary: Cucurbitacins, a class of secondary metabolites produced by the Cucurbitaceae family, have significant anticancer activity by inhibiting cell proliferation, invasion, and migration, inducing apoptosis, and encouraging cell cycle arrest. They also suppress the JAK-STAT3, Wnt, PI3K/Akt, and MAPK signaling pathways, which are essential for cancer cell survival and apoptosis. This study provides a comprehensive summary of potential molecular targets for cucurbitacins in suppressing various malignant processes.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Lan-Shan Liao, Lin-Jie Tan, Yin Chen, Qi-Yuan Yang, Muhammad Iqbal Choudhary, Ying-Ming Pan, Hai-Tao Tang, Gui-Fa Su, Hong Liang, Zhen-Feng Chen
Summary: An efficient one-pot reaction for the synthesis of oxoaporphine alkaloids has been developed, and their antitumor activities have been evaluated. Compound 4B exhibited the most potent activity, inhibiting the growth of T-24 tumor cells effectively and showing significant tumor growth inhibition in a mouse model. Substitution at the C3-position of the oxoaporphine core with -NO2 significantly enhanced the anticancer activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xing Huang, Chang-Hao Zhang, Hao Deng, Dan Wu, Hong-Yan Guo, Jung Joon Lee, Fen-Er Chen, Qing-Kun Shen, Li-Li Jin, Zhe-Shan Quan
Summary: A series of quillaic acid derivatives with different substituents were synthesized and evaluated for their antitumor activity against human cancer cell lines. One compound showed strong antiproliferative activity and induced apoptosis and cell cycle arrest by modulating signaling pathways.
FRONTIERS IN CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Weifeng Lin, Yingchun Yang, Yang Lei, Feifei An, Leming Sun, Yong Qin, Lianbing Zhang
Summary: The self-assembly of nonfluorescent peptides can generate fluorescent peptide nanoparticles for drug delivery and therapeutic agent tracking. A study demonstrated the self-assembly of the antitumor dipeptide carnosine into fluorescent carnosine nanoparticles in the presence of zinc ions, showing biocompatibility and fluorescence tracing ability.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Zhenxi Niu, Shuli Ma, Lei Zhang, Qibing Liu, Shengnan Zhang
Summary: A novel series of quinazoline derivatives were designed and synthesized, and compound 18 showed potent antitumor activity and selectivity against MGC-803 cells, with low micromolar cytotoxicity and inhibition of tumor growth.
Article
Biochemistry & Molecular Biology
Caio Cesar Candido, Henrique Vieira Reis Silva, Bruno Zavan, Marisa Ionta, Marilia Imaculada Frazao Barbosa, Antonio Carlos Doriguetto
Summary: In this study, novel ruthenium(II) complexes with metronidazole as a ligand were synthesized and characterized. The results showed that complexes (1) and (3) exhibited inhibitory effects on the proliferation of MCF-7 cells and induced apoptosis.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yuhan Wang, Xinxin Li, Debin Zheng, Yumiao Chen, Zhenghao Zhang, Zhimou Yang
Summary: A novel strategy utilizing self-assembly between ALP and PD-L1 to selectively degrade PD-L1 in tumor cells is reported. This strategy selectively encapsulates PD-L1 in nanomaterials for further degradation, showing potential for inhibiting tumor growth in animal models.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Srividya Swaminathan, Jebiti Haribabu, Naveen Kumar Kalagatur, Maroli Nikhil, Nithya Balakrishnan, Nattamai S. P. Bhuvanesh, Krishna Kadirvelu, Ponmalai Kolandaivel, Ramasamy Karvembu
Summary: The synthesis of fourteen new Ru-II-arene complexes were characterized and found to exhibit high toxicity towards IMR-32 cancer cells, with two complexes showing the highest activity and the ability to induce apoptosis and cell cycle arrest. These complexes also demonstrated good binding affinity with receptors commonly overexpressed in cancer cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Katia M. Oliveira, Joao Honorato, Felipe C. Demidoff, Mario S. Schultz, Chaquip D. Netto, Marcia R. Cominetti, Rodrigo S. Correa, Alzir A. Batista
Summary: The preparation and characterization of two new Ru(II)/diphosphine complexes containing Lapachol and Lawsone are described. These complexes exhibited high cytotoxicity against cancer cells, with complex (1) showing particular selectivity to triple-negative breast cancer cells. Mechanistic studies suggested that these complexes induce apoptosis in cancer cells through multiple pathways, making them promising candidates for cancer treatment.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Di Zhu, Yu Lu, Lin Gui, Wenjing Wang, Xi Hu, Su Chen, Yanming Wang, Yuji Wang
Summary: ZD-E-1 is a self-assembling carrier-free nanodrug that responds to pH, inhibits PAD4 activity, blocks neutrophil extracellular traps formation, and improves the tumor immune microenvironment.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Medicinal
Jie Gao, Yijiang Jia, Taledaohan Ayijiang, Tuohan MarMar, Xi Hu, Li Li, Yuanming Li, Yuji Wang
Summary: C10NLV-based TAX-loaded micelles inhibit the proliferative and metastatic capacities of lung cancer cells in a dose-dependent manner. These micelles reduce the volume and weight of tumors and the numbers of metastatic foci without inducing systemic toxicity.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Chemistry, Multidisciplinary
Jie Zhong, Weiye Wen, Jinjin Wang, Mengyu Zhang, Yijiang Jia, Xiaowei Ma, Yu-Xiong Su, Yuji Wang, Xinmiao Lan
Summary: A bone-targeted dual functional lipid-coated drug delivery system has been developed for precise delivery of drugs to tumor sites. The system demonstrates efficient anticancer effects and reduces bone resorption and loss.
PHARMACEUTICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shuangling Chen, Meng Liang, Chengli Wu, Xiaoyi Zhang, Yuji Wang, Ming Zhao
Summary: In order to mitigate the bleeding side effects during thrombolytic therapy, a novel biodegradable nanosystem was developed to deliver drugs specifically to the thrombus. The UK/PD-RGDS complex nano-globule showed 1.3 times higher thrombolytic potency compared to commercial UK. In vivo experiments demonstrated that the UK/PD-RGDS complex could achieve equivalent thrombolysis with a 90% reduction in UK dosage.
Article
Multidisciplinary Sciences
Wen Pan, Geng Hu, Shaorong Li, Guoqing Li, Xiaoyu Feng, Zhifang Wu, Dong Zhang, Lizheng Qin, Xue Wang, Liang Hu, Junji Xu, Lei Hu, Yijiang Jia, Xin Wen, Jinsong Wang, Chunmei Zhang, Jian Zhou, Wenbin Li, Xiaogang Wang, Yuji Wang, Songlin Wang
Summary: In this study, a swarm learning-based combination drug prediction system was developed to identify vitamin C as the drug of choice to be combined with nitrate. Nitrate nanoparticle called Nanonitrator was prepared using microencapsulation technology, which significantly increased the efficacy and effect duration of nitrate in irradiation-induced salivary gland injury. This study also provided a method for incorporating inorganic compounds into sustained-release nanoparticles.
Article
Pharmacology & Pharmacy
Shangyan Gu, Yu Lu, Yuji Wang, Wensheng Lu, Wei Wang
Summary: In this study, the C18ADPA hydrogel was utilized as a drug carrier for in vivo delivery of a copper salt, promoting wound healing in a mouse model. Cryo-SEM images revealed a structural transition from a layered structure to a self-assembled fibrillar network after drug loading. The hydrogel formulation exhibited clear advantages in regenerating tissue structure.
Article
Chemistry, Medicinal
Di Zhu, Yu Lu, Bo Hu, Yuheng Pang, Bingru Liu, Miao Zhang, Wenjing Wang, Yuji Wang
Summary: This study aims to obtain highly targeted PAD4 inhibitors by modifying PAD4 protein inhibitors with different phenylboronic acid groups. The activity and mechanism of PBA-PAD4 inhibitors were examined in vitro and in vivo, showing significant antitumor effects and inhibition of tumor cell metastasis. The results suggest that PBA-PAD4 inhibitors have great potential in tumor therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Cong Liu, Lin Gui, Jia-Jia Zheng, Yong-Qiang Xu, Benli Song, Li Yi, Yijiang Jia, Ayijiang Taledaohan, Yuji Wang, Xingfa Gao, Zeng-Ying Qiao, Hao Wang, Zhiyong Tang
Summary: Metaloxide nanozymes have emerged as the most promising candidates for treating oxidative stress-mediated disorders, but their current efficacy is insufficient. This study introduces an intrinsic strain-mediated ultrathin ceria nanoantioxidant, which exhibits enhanced SOD-mimetic and total antioxidant activities. In vivo experiments demonstrate that these ultrathin ceria nanoplates can significantly improve the treatment of ischemic stroke, outperforming the commonly used drug edaravone.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Pharmacology & Pharmacy
Yuheng Pang, Runze Shi, Liujia Chan, Yu Lu, Di Zhu, Tong Liu, Meisi Yan, Yuji Wang, Wenjing Wang
Summary: This study investigated the synergistic potential of Vorinostat (SAHA) and Doxorubicin (DOX) in combination against triple-negative breast cancer (TNBC). The results showed that the combination of these two drugs could enhance the inhibitory effect on cancer cell proliferation, alter cell mitotic phase, and regulate the immune microenvironment within tumors. This presents a promising avenue for innovative combination chemotherapy in the context of TNBC.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Engineering, Biomedical
Xinmiao Lan, Jie Zhong, Regina Huang, Yuhan Liu, Xiaowei Ma, Xuan Li, Dan Zhao, Guangchao Qing, Yuxuan Zhang, Lu Liu, Jinjin Wang, Xu Ma, Ting Luo, Weisheng Guo, Yuji Wang, Li-Li Li, Yu-Xiong Su, Xing-Jie Liang
Summary: Antimicrobial peptides (AMPs), a class of natural and synthetic oligopeptides, have shown potential in obtaining new therapeutic agents with improved properties. Self-assembled AMPs have become a hot topic for biomedical applications due to their diverse forms and advantages, such as stability and biocompatibility.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Bo Hu, Jinyuan Gao, Yu Lu, Yuji Wang
Summary: Hydrogels are suitable materials for loading drug delivery agents due to their high water content and cross-linked nature. Biodegradable hydrogels have become a promising technology in disease treatment and drug delivery methods due to their advantageous properties.
Article
Chemistry, Multidisciplinary
Yu Lu, Di Zhu, Liujia Chan, Bo Hu, MarMar Tuohan, Li Li, Wei Wang, Yuji Wang
Summary: In this study, a carboline derivative and its ruthenium complex, NBD and NBD-Ru, were synthesized and characterized. The introduction of ruthenium improved the solubility and stability, enabling NBD-Ru to self-assemble into nanoparticles with the EPR effect. The binding affinity with transferrin increased significantly after complexation, allowing NBD-Ru to target and selectively kill tumors via the Tf/TfR pathway. Moreover, ruthenium assisted the complex in achieving nuclear penetration and interact with DNA to kill tumor cells. In vivo experiments confirmed the in vitro findings, showing that NBD-Ru inhibited primary tumor growth and lung metastasis, while reducing systemic toxicity and improving biosafety.
Article
Medicine, Research & Experimental
Yijiang Jia, Ayijiang Taledaohan, Renbo Jia, Xin Wang, Yunshu Jia, Jiawang Liu, Yuji Wang
Summary: This study focuses on the development of a stimulus-responsive nanodrug that can respond to the tumor microenvironment by inhibiting the activity of PAD4, blocking the formation of neutrophil extracellular traps (NETs), and improving the tumor immune microenvironment. The nanodrug was constructed by covalently attaching a PAD4 inhibitor to a chitosan modified with RGD sequence peptide. The results showed that this nanodrug exhibited excellent anti-tumor and anti-metastatic properties both in vitro and in vivo, and it also modulated the ratio of immune cells in tumor-bearing mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Chemistry, Multidisciplinary
Yu Lu, Di Zhu, Quynh Le, Yuji Wang, Wei Wang
Summary: This review highlights the importance of ruthenium complexes in antitumor drug research, including the transition from single chemotherapy drugs to combination therapy and the evolution of drug delivery systems. The review also discusses the applications of ruthenium complexes in combination therapy, such as photodynamic therapy, photothermal therapy, photoactivated chemotherapy, and immunotherapy, as well as the future prospects of ruthenium-based antitumor drugs.