Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells

Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters

(2020) Unmesh Jadhav et al.   MOLECULAR CELL

A cell atlas of the adult Drosophila midgut

(2020) Ruei-Jiun Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Switch in Tissue Stem Cell Identity Causes Neuroendocrine Tumors in Drosophila Gut

(2020) Zhaohui Li et al.   Cell Reports

Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction

(2019) Imilce A. Rodriguez-Fernandez et al.   Nature Communications

The single-cell transcriptional landscape of mammalian organogenesis

(2019) Junyue Cao et al.   NATURE

Polycomb/Trithorax Antagonism: Cellular Memory in Stem Cell Fate and Function

(2019) Marjorie Brand et al.   Cell Stem Cell

Stem Cell Proliferation Is Kept in Check by the Chromatin Regulators Kismet/CHD7/CHD8 and Trr/MLL3/4

(2019) Louis Gervais et al.   DEVELOPMENTAL CELL

Loss of PRC1 activity in different stem cell compartments activates a common transcriptional program with cell type–dependent outcomes

(2019) Silvia Pivetti et al.   Science Advances

Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation

(2019) Jie Zhou et al.   Nature Communications

Intestinal Stem Cell Aging: Origins and Interventions

(2019) Heinrich Jasper   Annual Review of Physiology

Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression

(2018) Rene C. Adam et al.   Cell Stem Cell

Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel

(2018) Li He et al.   NATURE

Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells

(2018) Jun Chen et al.   NATURE CELL BIOLOGY

Cellular and epigenetic drivers of stem cell ageing

(2018) Maria Ermolaeva et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polycomb and Trithorax Group Genes inDrosophila

(2017) Judith A. Kassis et al.   GENETICS

Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity

(2017) J J Worthington et al.   Mucosal Immunology

Reversed graph embedding resolves complex single-cell trajectories

(2017) Xiaojie Qiu et al.   NATURE METHODS

Molecular mechanisms underlying lineage bias in aging hematopoiesis

(2017) Harold K. Elias et al.   SEMINARS IN HEMATOLOGY

Polycomb and Hox Genes Control JNK-Induced Remodeling of the Segment Boundary during Drosophila Morphogenesis

(2017) Solange Roumengous et al.   Cell Reports

Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells

(2017) Kodandaramireddy Nalapareddy et al.   Cell Reports

Piwi Is Required to Limit Exhaustion of Aging Somatic Stem Cells

(2017) Pedro Sousa-Victor et al.   Cell Reports

Polycomb and Trithorax Group Genes inDrosophila

(2017) Judith A. Kassis et al.   GENETICS

Preventing Age-Related Decline of Gut Compartmentalization Limits Microbiota Dysbiosis and Extends Lifespan

(2016) Hongjie Li et al.   Cell Host & Microbe

Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity

(2016) Fulvio Chiacchiera et al.   Cell Stem Cell

PRC2 preserves intestinal progenitors and restricts secretory lineage commitment

(2016) Fulvio Chiacchiera et al.   EMBO JOURNAL

Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells

(2016) Martijn A.J. Koppens et al.   GASTROENTEROLOGY

Epigenetic perturbations in aging stem cells

(2016) Sara Russo Krauss et al.   MAMMALIAN GENOME

Epigenetic control of adult stem cell function

(2016) Alexandra Avgustinova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

The Yin and Yang of Chromatin Dynamics In Stem Cell Fate Selection

(2016) Rene C. Adam et al.   TRENDS IN GENETICS

Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells

(2016) Aster H. Juan et al.   Cell Reports

Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer

(2016) Anne Laugesen et al.   Cold Spring Harbor Perspectives in Medicine

Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2

(2015) S. A. Kinkel et al.   BLOOD

Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease

(2015) Isabel Beerman et al.   Cell Stem Cell

Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging

(2015) Katarzyna Siudeja et al.   Cell Stem Cell

Trithorax and Polycomb group-dependent regulation: a tale of opposing activities

(2015) S. J. Geisler et al.   DEVELOPMENT

Genome-wide activities of Polycomb complexes control pervasive transcription

(2015) Hun-Goo Lee et al.   GENOME RESEARCH

Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut

(2015) Devanjali Dutta et al.   Cell Reports

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan

(2014) Linlin Guo et al.   CELL

Geroconversion of aged muscle stem cells under regenerative pressure

(2014) Pedro Sousa-Victor et al.   CELL CYCLE

Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal

(2014) Deqiang Sun et al.   Cell Stem Cell

Ezh2 Regulates Adult Hippocampal Neurogenesis and Memory

(2014) J. Zhang et al.   JOURNAL OF NEUROSCIENCE

Intestinal neuroendocrine cells and goblet cells are mediators of IL-17A-amplified epithelial IL-17C production in human inflammatory bowel disease

(2014) M Friedrich et al.   Mucosal Immunology

Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity

(2014) Tae-Hee Kim et al.   NATURE

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Chromatin state dynamics during blood formation

(2014) D. Lara-Astiaso et al.   SCIENCE

Enteroendocrine Cells Support Intestinal Stem-Cell-Mediated Homeostasis in Drosophila

(2014) Alla Amcheslavsky et al.   Cell Reports

Integration of UPRER and Oxidative Stress Signaling in the Control of Intestinal Stem Cell Proliferation

(2014) Lifen Wang et al.   PLoS Genetics

Isolating Intestinal Stem Cells from Adult Drosophila Midguts by FACS to Study Stem Cell Behavior During Aging

(2014) Helen M. Tauc et al.   Jove-Journal of Visualized Experiments

EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

(2013) Wendy Béguelin et al.   CANCER CELL

Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-Stage-Specific Manner

(2013) Huafeng Xie et al.   Cell Stem Cell

Beyond Gene Discovery in Inflammatory Bowel Disease: The Emerging Role of Epigenetics

(2013) Nicholas T. Ventham et al.   GASTROENTEROLOGY

Polycomb-Dependent H3K27me1 and H3K27me2 Regulate Active Transcription and Enhancer Fidelity

(2013) Karin J. Ferrari et al.   MOLECULAR CELL

Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging

(2013) Ling Liu et al.   Cell Reports

Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila

(2013) Nicolas Buchon et al.   Cell Reports

Ezh1 Is Required for Hematopoietic Stem Cell Maintenance and Prevents Senescence-like Cell Cycle Arrest

(2012) Isabel Hidalgo et al.   Cell Stem Cell

Age- and oxidative stress-induced DNA damage in Drosophila intestinal stem cells as marked by Gamma-H2AX

(2012) Joung-Sun Park et al.   EXPERIMENTAL GERONTOLOGY

Ezh2 maintains a key phase of muscle satellite cell expansion but does not regulate terminal differentiation

(2012) S. Woodhouse et al.   JOURNAL OF CELL SCIENCE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

(2012) M. Rera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Redox Regulation by Keap1 and Nrf2 Controls Intestinal Stem Cell Proliferation in Drosophila

(2011) Christine E. Hochmuth et al.   Cell Stem Cell

Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells

(2011) A. H. Juan et al.   GENES & DEVELOPMENT

EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

(2011) E. Ezhkova et al.   GENES & DEVELOPMENT

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Bmi1 Is Expressed in Postnatal Myogenic Satellite Cells, Controls Their Maintenance and Plays an Essential Role in Repeated Muscle Regeneration

(2011) Lesley G. Robson et al.   PLoS One

The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

(2011) K. S. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

(2010) D. B. Yap et al.   BLOOD

Poised Lineage Specification in Multipotential Hematopoietic Stem and Progenitor Cells by the Polycomb Protein Bmi1

(2010) Hideyuki Oguro et al.   Cell Stem Cell

chinmo Is a Functional Effector of the JAK/STAT Pathway that Regulates Eye Development, Tumor Formation, and Stem Cell Self-Renewal in Drosophila

(2010) Maria Sol Flaherty et al.   DEVELOPMENTAL CELL

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

(2010) C. J. Sneeringer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila

(2010) Benoît Biteau et al.   PLoS Genetics

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut

(2009) Huaqi Jiang et al.   CELL

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

(2009) N. Buchon et al.   GENES & DEVELOPMENT

JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut

(2008) Benoît Biteau et al.   Cell Stem Cell

EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency

(2008) Xiaohua Shen et al.   MOLECULAR CELL