Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells
出版年份 2021 全文链接
标题
Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells
作者
关键词
-
出版物
eLife
Volume 10, Issue -, Pages -
出版商
eLife Sciences Publications, Ltd
发表日期
2021-03-16
DOI
10.7554/elife.62250
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters
- (2020) Unmesh Jadhav et al. MOLECULAR CELL
- A cell atlas of the adult Drosophila midgut
- (2020) Ruei-Jiun Hung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Switch in Tissue Stem Cell Identity Causes Neuroendocrine Tumors in Drosophila Gut
- (2020) Zhaohui Li et al. Cell Reports
- Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction
- (2019) Imilce A. Rodriguez-Fernandez et al. Nature Communications
- The single-cell transcriptional landscape of mammalian organogenesis
- (2019) Junyue Cao et al. NATURE
- Polycomb/Trithorax Antagonism: Cellular Memory in Stem Cell Fate and Function
- (2019) Marjorie Brand et al. Cell Stem Cell
- Stem Cell Proliferation Is Kept in Check by the Chromatin Regulators Kismet/CHD7/CHD8 and Trr/MLL3/4
- (2019) Louis Gervais et al. DEVELOPMENTAL CELL
- Loss of PRC1 activity in different stem cell compartments activates a common transcriptional program with cell type–dependent outcomes
- (2019) Silvia Pivetti et al. Science Advances
- Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
- (2019) Jie Zhou et al. Nature Communications
- Intestinal Stem Cell Aging: Origins and Interventions
- (2019) Heinrich Jasper Annual Review of Physiology
- Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression
- (2018) Rene C. Adam et al. Cell Stem Cell
- Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel
- (2018) Li He et al. NATURE
- Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells
- (2018) Jun Chen et al. NATURE CELL BIOLOGY
- Cellular and epigenetic drivers of stem cell ageing
- (2018) Maria Ermolaeva et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Polycomb and Trithorax Group Genes inDrosophila
- (2017) Judith A. Kassis et al. GENETICS
- Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity
- (2017) J J Worthington et al. Mucosal Immunology
- Reversed graph embedding resolves complex single-cell trajectories
- (2017) Xiaojie Qiu et al. NATURE METHODS
- Molecular mechanisms underlying lineage bias in aging hematopoiesis
- (2017) Harold K. Elias et al. SEMINARS IN HEMATOLOGY
- Polycomb and Hox Genes Control JNK-Induced Remodeling of the Segment Boundary during Drosophila Morphogenesis
- (2017) Solange Roumengous et al. Cell Reports
- Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells
- (2017) Kodandaramireddy Nalapareddy et al. Cell Reports
- Piwi Is Required to Limit Exhaustion of Aging Somatic Stem Cells
- (2017) Pedro Sousa-Victor et al. Cell Reports
- Polycomb and Trithorax Group Genes inDrosophila
- (2017) Judith A. Kassis et al. GENETICS
- Preventing Age-Related Decline of Gut Compartmentalization Limits Microbiota Dysbiosis and Extends Lifespan
- (2016) Hongjie Li et al. Cell Host & Microbe
- Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity
- (2016) Fulvio Chiacchiera et al. Cell Stem Cell
- PRC2 preserves intestinal progenitors and restricts secretory lineage commitment
- (2016) Fulvio Chiacchiera et al. EMBO JOURNAL
- Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells
- (2016) Martijn A.J. Koppens et al. GASTROENTEROLOGY
- Epigenetic perturbations in aging stem cells
- (2016) Sara Russo Krauss et al. MAMMALIAN GENOME
- Epigenetic control of adult stem cell function
- (2016) Alexandra Avgustinova et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- deepTools2: a next generation web server for deep-sequencing data analysis
- (2016) Fidel Ramírez et al. NUCLEIC ACIDS RESEARCH
- The Yin and Yang of Chromatin Dynamics In Stem Cell Fate Selection
- (2016) Rene C. Adam et al. TRENDS IN GENETICS
- Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells
- (2016) Aster H. Juan et al. Cell Reports
- Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer
- (2016) Anne Laugesen et al. Cold Spring Harbor Perspectives in Medicine
- Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2
- (2015) S. A. Kinkel et al. BLOOD
- Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease
- (2015) Isabel Beerman et al. Cell Stem Cell
- Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging
- (2015) Katarzyna Siudeja et al. Cell Stem Cell
- Trithorax and Polycomb group-dependent regulation: a tale of opposing activities
- (2015) S. J. Geisler et al. DEVELOPMENT
- Genome-wide activities of Polycomb complexes control pervasive transcription
- (2015) Hun-Goo Lee et al. GENOME RESEARCH
- Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut
- (2015) Devanjali Dutta et al. Cell Reports
- Trimmomatic: a flexible trimmer for Illumina sequence data
- (2014) Anthony M. Bolger et al. BIOINFORMATICS
- PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan
- (2014) Linlin Guo et al. CELL
- Geroconversion of aged muscle stem cells under regenerative pressure
- (2014) Pedro Sousa-Victor et al. CELL CYCLE
- Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal
- (2014) Deqiang Sun et al. Cell Stem Cell
- Ezh2 Regulates Adult Hippocampal Neurogenesis and Memory
- (2014) J. Zhang et al. JOURNAL OF NEUROSCIENCE
- Intestinal neuroendocrine cells and goblet cells are mediators of IL-17A-amplified epithelial IL-17C production in human inflammatory bowel disease
- (2014) M Friedrich et al. Mucosal Immunology
- Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity
- (2014) Tae-Hee Kim et al. NATURE
- The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
- (2014) Cole Trapnell et al. NATURE BIOTECHNOLOGY
- Chromatin state dynamics during blood formation
- (2014) D. Lara-Astiaso et al. SCIENCE
- Enteroendocrine Cells Support Intestinal Stem-Cell-Mediated Homeostasis in Drosophila
- (2014) Alla Amcheslavsky et al. Cell Reports
- Integration of UPRER and Oxidative Stress Signaling in the Control of Intestinal Stem Cell Proliferation
- (2014) Lifen Wang et al. PLoS Genetics
- Isolating Intestinal Stem Cells from Adult Drosophila Midguts by FACS to Study Stem Cell Behavior During Aging
- (2014) Helen M. Tauc et al. Jove-Journal of Visualized Experiments
- EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation
- (2013) Wendy Béguelin et al. CANCER CELL
- Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-Stage-Specific Manner
- (2013) Huafeng Xie et al. Cell Stem Cell
- Beyond Gene Discovery in Inflammatory Bowel Disease: The Emerging Role of Epigenetics
- (2013) Nicholas T. Ventham et al. GASTROENTEROLOGY
- Polycomb-Dependent H3K27me1 and H3K27me2 Regulate Active Transcription and Enhancer Fidelity
- (2013) Karin J. Ferrari et al. MOLECULAR CELL
- Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging
- (2013) Ling Liu et al. Cell Reports
- Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila
- (2013) Nicolas Buchon et al. Cell Reports
- Ezh1 Is Required for Hematopoietic Stem Cell Maintenance and Prevents Senescence-like Cell Cycle Arrest
- (2012) Isabel Hidalgo et al. Cell Stem Cell
- Age- and oxidative stress-induced DNA damage in Drosophila intestinal stem cells as marked by Gamma-H2AX
- (2012) Joung-Sun Park et al. EXPERIMENTAL GERONTOLOGY
- Ezh2 maintains a key phase of muscle satellite cell expansion but does not regulate terminal differentiation
- (2012) S. Woodhouse et al. JOURNAL OF CELL SCIENCE
- Fiji: an open-source platform for biological-image analysis
- (2012) Johannes Schindelin et al. NATURE METHODS
- Fast gapped-read alignment with Bowtie 2
- (2012) Ben Langmead et al. NATURE METHODS
- Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila
- (2012) M. Rera et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of chromatin by histone modifications
- (2011) Andrew J Bannister et al. CELL RESEARCH
- Redox Regulation by Keap1 and Nrf2 Controls Intestinal Stem Cell Proliferation in Drosophila
- (2011) Christine E. Hochmuth et al. Cell Stem Cell
- Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells
- (2011) A. H. Juan et al. GENES & DEVELOPMENT
- EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair
- (2011) E. Ezhkova et al. GENES & DEVELOPMENT
- The Polycomb complex PRC2 and its mark in life
- (2011) Raphaël Margueron et al. NATURE
- Bmi1 Is Expressed in Postnatal Myogenic Satellite Cells, Controls Their Maintenance and Plays an Essential Role in Repeated Muscle Regeneration
- (2011) Lesley G. Robson et al. PLoS One
- The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations
- (2011) K. S. Yan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- BEDTools: a flexible suite of utilities for comparing genomic features
- (2010) Aaron R. Quinlan et al. BIOINFORMATICS
- Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
- (2010) D. B. Yap et al. BLOOD
- Poised Lineage Specification in Multipotential Hematopoietic Stem and Progenitor Cells by the Polycomb Protein Bmi1
- (2010) Hideyuki Oguro et al. Cell Stem Cell
- chinmo Is a Functional Effector of the JAK/STAT Pathway that Regulates Eye Development, Tumor Formation, and Stem Cell Self-Renewal in Drosophila
- (2010) Maria Sol Flaherty et al. DEVELOPMENTAL CELL
- Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
- (2010) Sven Heinz et al. MOLECULAR CELL
- Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
- (2010) Ryan D Morin et al. NATURE GENETICS
- Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
- (2010) C. J. Sneeringer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila
- (2010) Benoît Biteau et al. PLoS Genetics
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
- Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut
- (2009) Huaqi Jiang et al. CELL
- Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila
- (2009) N. Buchon et al. GENES & DEVELOPMENT
- JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut
- (2008) Benoît Biteau et al. Cell Stem Cell
- EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency
- (2008) Xiaohua Shen et al. MOLECULAR CELL
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