Whole-genome sequencing analysis of semi-supercentenarians

The Contextualized Genetics of Human Longevity

(2020) Claudio Franceschi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pan-mammalian analysis of molecular constraints underlying extended lifespan

(2020) Amanda Kowalczyk et al.   eLife

Genomic history of the Italian population recapitulates key evolutionary dynamics of both Continental and Southern Europeans

(2020) Marco Sazzini et al.   BMC BIOLOGY

Genetic Risk Score for Coronary Disease Identifies Predispositions to Cardiovascular and Noncardiovascular Diseases

(2019) Ioanna Ntalla et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe

(2019) A. Raveane et al.   Science Advances

Clonal hematopoiesis in human aging and disease

(2019) Siddhartha Jaiswal et al.   SCIENCE

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Impact of demography and population dynamics on the genetic architecture of human longevity

(2018) Cristina Giuliani et al.   Aging-US

A One-Penny Imputed Genome from Next-Generation Reference Panels

(2018) Brian L. Browning et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework

(2018) Cristina Giuliani et al.   CIRCULATION RESEARCH

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

A decade of progress on the genetic basis of coronary artery disease. Practical insights for the internist

(2017) Domenico Girelli et al.   European Journal of Internal Medicine

Limitations and risks of meta-analyses of longevity studies

(2017) Paola Sebastiani et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases

(2017) Cristina Giuliani et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Association analyses based on false discovery rate implicate new loci for coronary artery disease

(2017) Christopher P Nelson et al.   NATURE GENETICS

Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease

(2017) Pim van der Harst et al.   CIRCULATION RESEARCH

Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2

(2016) E. B. van den Akker et al.   BLOOD

Whole-Genome Sequencing of a Healthy Aging Cohort

(2016) Galina A. Erikson et al.   CELL

Next-generation genotype imputation service and methods

(2016) Sayantan Das et al.   NATURE GENETICS

Healthy ageing, the genome and the environment

(2016) Kaare Christensen et al.   Nature Reviews Endocrinology

Joint Bayesian inference of risk variants and tissue-specific epigenomic enrichments across multiple complex human diseases

(2016) Yue Li et al.   NUCLEIC ACIDS RESEARCH

Complex interplay between neutral and adaptive evolution shaped differential genomic background and disease susceptibility along the Italian peninsula

(2016) Marco Sazzini et al.   Scientific Reports

Novel loci and pathways significantly associated with longevity

(2016) Yi Zeng et al.   Scientific Reports

Joint influence of small-effect genetic variants on human longevity

(2016) Anatoliy I. Yashin et al.   Aging-US

Genetic evidence for common pathways in human age-related diseases

(2015) Simon C. Johnson et al.   AGING CELL

Increasing Sibling Relative Risk of Survival to Older and Older Ages and the Importance of Precise Definitions of “Aging,” “Life Span,” and “Longevity”

(2015) Paola Sebastiani et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Genetics of aging, health, and survival: dynamic regulation of human longevity related traits

(2015) Anatoliy I. Yashin et al.   Frontiers in Genetics

The Use of Non-Variant Sites to Improve the Clinical Assessment of Whole-Genome Sequence Data

(2015) Alberto Ferrarini et al.   PLoS One

Joint Analysis of Functional Genomic Data and Genome-wide Association Studies of 18 Human Traits

(2014) Joseph K. Pickrell   AMERICAN JOURNAL OF HUMAN GENETICS

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Age-related mutations associated with clonal hematopoietic expansion and malignancies

(2014) Mingchao Xie et al.   NATURE MEDICINE

Dual functions of NME1 in suppression of cell motility and enhancement of genomic stability in melanoma

(2014) David M. Kaetzel et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Whole-Genome Sequencing of the World’s Oldest People

(2014) Hinco J. Gierman et al.   PLoS One

The Three Genetics (Nuclear DNA, Mitochondrial DNA, and Gut Microbiome) of Longevity in Humans Considered as Metaorganisms

(2014) Paolo Garagnani et al.   Biomed Research International

Disease variants in genomes of 44 centenarians

(2014) Yun Freudenberg-Hua et al.   Molecular Genetics & Genomic Medicine

Isaac: ultra-fast whole-genome secondary analysis on Illumina sequencing platforms

(2013) Come Raczy et al.   BIOINFORMATICS

Polymorphisms in STK17A gene are associated with systemic lupus erythematosus and its clinical manifestations

(2013) Andréia Maria da Silva Fonseca et al.   GENE

Health Span Approximates Life Span Among Many Supercentenarians: Compression of Morbidity at the Approximate Limit of Life Span

(2012) S. L. Andersen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Genetics of Extreme Longevity: Lessons from the New England Centenarian Study

(2012) Paola Sebastiani et al.   Frontiers in Genetics

Integrated annotation and analysis of genetic variants from next-generation sequencing studies with variant tools

(2011) F. A. San Lucas et al.   BIOINFORMATICS

Biliverdin reductase A in the prevention of cellular senescence against oxidative stress

(2011) Sung Young Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

Basic statistical analysis in genetic case-control studies

(2011) Geraldine M Clarke et al.   Nature Protocols

Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase

(2011) B. Wegiel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Data quality control in genetic case-control association studies

(2010) Carl A Anderson et al.   Nature Protocols

i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study

(2010) K. Zhang et al.   NUCLEIC ACIDS RESEARCH

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

(2010) M. Beekman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shared and Unique Gene Expression in Systemic Lupus Erythematosus Depending on Disease Activity

(2009) Paula Sandrin-Garcia et al.   Annals of the New York Academy of Sciences

Ageing populations: the challenges ahead

(2009) Kaare Christensen et al.   LANCET

Rapid and Accurate Multiple Testing Correction and Power Estimation for Millions of Correlated Markers

(2009) Buhm Han et al.   PLoS Genetics

Power for Genetic Association Study of Human Longevity Using the Case-Control Design

(2008) Q. Tan et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY