Cryo-EM structure of P. falciparum circumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts

A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein

(2018) Joshua Tan et al.   NATURE MEDICINE

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

(2018) Neville K Kisalu et al.   NATURE MEDICINE

Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope

(2018) Katharina Imkeller et al.   SCIENCE

Structural Basis for the Specific Neutralization of Stx2a with a Camelid Single Domain Antibody Fragment

(2018) Robert Bernedo-Navarro et al.   Toxins

Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies

(2017) Gianna Triller et al.   IMMUNITY

Spread of a single multidrug resistant malaria parasite lineage ( PfPailin ) to Vietnam

(2017) Mallika Imwong et al.   LANCET INFECTIOUS DISEASES

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Structural basis for antibody recognition of the NANP repeats inPlasmodium falciparumcircumsporozoite protein

(2017) David Oyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein

(2017) Camilla R. Fisher et al.   PLoS Pathogens

Enhancing protective immunity to malaria with a highly immunogenic virus-like particle vaccine

(2017) Katharine A. Collins et al.   Scientific Reports

Force Spectroscopy of thePlasmodium falciparumVaccine Candidate Circumsporozoite Protein Suggests a Mechanically Pliable Repeat Region

(2016) Aditya Prasad Patra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fractional Third and Fourth Dose of RTS,S/AS01 Malaria Candidate Vaccine: A Phase 2a Controlled Human Malaria Parasite Infection and Immunogenicity Study

(2016) Jason A. Regules et al.   JOURNAL OF INFECTIOUS DISEASES

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Seven-Year Efficacy of RTS,S/AS01 Malaria Vaccine among Young African Children

(2016) Ally Olotu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reversible Conformational Change in the Plasmodium falciparum Circumsporozoite Protein Masks Its Adhesion Domains

(2015) Raul Herrera et al.   INFECTION AND IMMUNITY

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

(2015)   LANCET

Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine

(2015) Daniel E. Neafsey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Insights into the Immunological Properties of Intrinsically Disordered Malaria Proteins Using Proteome Scale Predictions

(2015) Andrew J. Guy et al.   PLoS One

IgG2 Antibodies against a Clinical Grade Plasmodium falciparum CSP Vaccine Antigen Associate with Protection against Transgenic Sporozoite Challenge in Mice

(2014) Robert Schwenk et al.   PLoS One

Efficacy and Safety of the RTS,S/AS01 Malaria Vaccine during 18 Months after Vaccination: A Phase 3 Randomized, Controlled Trial in Children and Young Infants at 11 African Sites

(2014)   PLOS MEDICINE

Comparative population structure of Plasmodium falciparum circumsporozoite protein NANP repeat lengths in Lilongwe, Malawi

(2013) Natalie M. Bowman et al.   Scientific Reports

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Unexpected fold in the circumsporozoite protein target of malaria vaccines

(2012) M. B. Doud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure of thePlasmodium falciparumCircumsporozoite Protein, a Leading Malaria Vaccine Candidate

(2009) Matthew L. Plassmeyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Refinement of Protein Structures into Low-Resolution Density Maps Using Rosetta

(2009) Frank DiMaio et al.   JOURNAL OF MOLECULAR BIOLOGY

Appion: An integrated, database-driven pipeline to facilitate EM image processing

(2009) Gabriel C. Lander et al.   JOURNAL OF STRUCTURAL BIOLOGY

DoG Picker and TiltPicker: Software tools to facilitate particle selection in single particle electron microscopy

(2009) N.R. Voss et al.   JOURNAL OF STRUCTURAL BIOLOGY