Intercellular viral spread and intracellular transposition of Drosophila gypsy

Presymptomatic Increase of an Extracellular RNA in Blood Plasma Associates with the Development of Alzheimer’s Disease

(2020) Zhangming Yan et al.   CURRENT BIOLOGY

The HERV-K accessory protein Np9 controls viability and migration of teratocarcinoma cells

(2019) Susana M. Chan et al.   PLoS One

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

The Lupus Susceptibility Locus Sgp3 Encodes the Suppressor of Endogenous Retrovirus Expression SNERV

(2019) Rebecca S. Treger et al.   IMMUNITY

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

(2019) Matthew Simon et al.   Cell Metabolism

Cellular labeling of endogenous retrovirus replication (CLEVR) reveals de novo insertions of the gypsy retrotransposable element in cell culture and in both neurons and glial cells of aging fruit flies

(2019) Yung-Heng Chang et al.   PLOS BIOLOGY

Somatic LINE-1 retrotransposition in cortical neurons and non-brain tissues of Rett patients and healthy individuals

(2019) Boxun Zhao et al.   PLoS Genetics

Extracellular vesicles mediate the horizontal transfer of an active LINE-1 retrotransposon

(2019) Yumi Kawamura et al.   Journal of Extracellular Vesicles

The Gypsy Endogenous Retrovirus Drives Non-Cell-Autonomous Propagation in a Drosophila TDP-43 Model of Neurodegeneration

(2019) Yung-Heng Chang et al.   CURRENT BIOLOGY

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

(2019) Oliver H. Tam et al.   Cell Reports

Endogenous retroviruses are associated with hippocampus-based memory impairment

(2019) Roman Sankowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer

(2018) Elissa D. Pastuzyn et al.   CELL

Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons

(2018) James Ashley et al.   CELL

The Retrotransposon storm and the dangers of a Collyer's genome

(2018) Josh Dubnau   CURRENT OPINION IN GENETICS & DEVELOPMENT

Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE‐1 repression

(2018) François‐Xavier Blaudin de Thé et al.   EMBO JOURNAL

Humoral immunity response to human endogenous retroviruses K/W differentiates between amyotrophic lateral sclerosis and other neurological diseases

(2018) G. Arru et al.   EUROPEAN JOURNAL OF NEUROLOGY

L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis

(2018) Stephanie N. Schauer et al.   GENOME RESEARCH

Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies

(2018) Wenyan Sun et al.   NATURE NEUROSCIENCE

Longevity and transposon defense, the case of termite reproductives

(2018) Daniel Elsner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

L1 Retrotransposon Heterogeneity in Ovarian Tumor Cell Evolution

(2018) Thu H.M. Nguyen et al.   Cell Reports

Tau Activates Transposable Elements in Alzheimer’s Disease

(2018) Caiwei Guo et al.   Cell Reports

Retrotransposon-induced mosaicism in the neural genome

(2018) Gabriela O. Bodea et al.   Open Biology

L1 retrotransposition in the soma: a field jumping ahead

(2018) Geoffrey J. Faulkner et al.   Mobile DNA

Reconstruction of the cell entry pathway of an extinct virus

(2018) Lindsey R. Robinson-McCarthy et al.   PLoS Pathogens

Mobile DNA in Health and Disease

(2017) Haig H. Kazazian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human transposon insertion profiling: Analysis, visualization and identification of somatic LINE-1 insertions in ovarian cancer

(2017) Zuojian Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piwi Is Required to Limit Exhaustion of Aging Somatic Stem Cells

(2017) Pedro Sousa-Victor et al.   Cell Reports

Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS

(2017) Lisa Krug et al.   PLoS Genetics

A hot L1 retrotransposon evades somatic repression and initiates human colorectal cancer

(2016) Emma C. Scott et al.   GENOME RESEARCH

Somatically Acquired LINE-1 Insertions in Normal Esophagus Undergo Clonal Expansion in Esophageal Squamous Cell Carcinoma

(2016) Tara T. Doucet-O'Hare et al.   HUMAN MUTATION

Familial retinoblastoma due to intronic LINE-1 insertion causes aberrant and noncanonical mRNA splicing of the RB1 gene

(2016) Carlos Rodríguez-Martín et al.   JOURNAL OF HUMAN GENETICS

Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span inDrosophila

(2016) Jason G. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan

(2016) Brian C. Jones et al.   Nature Communications

Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells

(2016) Fuling Zhou et al.   Oncotarget

Environment-driven somatic mosaicism in brain disorders

(2016) Tracy A. Bedrosian et al.   Genome Medicine

Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme

(2016) Patricia E. Carreira et al.   Mobile DNA

Human endogenous retroviruses and cancer

(2016) Gonzalez-Cao María et al.   Cancer Biology & Medicine

Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues

(2016) Marco De Cecco et al.   Aging-US

Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts

(2015) I. Scarfo et al.   BLOOD

Ubiquitous L1 Mosaicism in Hippocampal Neurons

(2015) Kyle R. Upton et al.   CELL

What might retrotransposons teach us about aging?

(2015) Patrick H. Maxwell   CURRENT GENETICS

Genetic Changes Shaping the Human Brain

(2015) Byoung-Il Bae et al.   DEVELOPMENTAL CELL

p53 genes function to restrain mobile elements

(2015) Annika Wylie et al.   GENES & DEVELOPMENT

DNA methylation modulates HERV-E expression in CD4+ T cells from systemic lupus erythematosus patients

(2015) Zhouwei Wu et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Alternative transcription initiation leads to expression of a novel ALK isoform in cancer

(2015) Thomas Wiesner et al.   NATURE

Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma

(2015) Nemanja Rodić et al.   NATURE MEDICINE

LINE-1 expression and retrotransposition in Barrett’s esophagus and esophageal carcinoma

(2015) Tara T. Doucet-O'Hare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human endogenous retrovirus-K contributes to motor neuron disease

(2015) Wenxue Li et al.   Science Translational Medicine

Long Interspersed Element-1 Protein Expression Is a Hallmark of Many Human Cancers

(2014) Nemanja Rodić et al.   AMERICAN JOURNAL OF PATHOLOGY

L1 Retrotransposons and Somatic Mosaicism in the Brain

(2014) Sandra R. Richardson et al.   Annual Review of Genetics

Transcriptional landscape of repetitive elements in normal and cancer human cells

(2014) Steven W Criscione et al.   BMC GENOMICS

The role of epigenetics in age-related macular degeneration

(2014) M Gemenetzi et al.   EYE

Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma

(2014) F. E. Lock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain

(2014) Xuyu Cai et al.   Cell Reports

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

(2013) Marco De Cecco et al.   AGING CELL

Endogenous Retrotransposition Activates Oncogenic Pathways in Hepatocellular Carcinoma

(2013) Ruchi Shukla et al.   CELL

L1 retrotransposons, cancer stem cells and oncogenesis

(2013) Patricia E. Carreira et al.   FEBS Journal

The Role of Transposable Elements in Health and Diseases of the Central Nervous System

(2013) M. T. Reilly et al.   JOURNAL OF NEUROSCIENCE

Activation of transposable elements during aging and neuronal decline in Drosophila

(2013) Wanhe Li et al.   NATURE NEUROSCIENCE

Somatic Mutation, Genomic Variation, and Neurological Disease

(2013) A. Poduri et al.   SCIENCE

RNA editing regulates transposon-mediated heterochromatic gene silencing

(2013) Yiannis A. Savva et al.   Nature Communications

Active Transposition in Genomes

(2012) Cheng Ran Lisa Huang et al.   Annual Review of Genetics

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88

(2012) Valeria Tarallo et al.   CELL

Single-Neuron Sequencing Analysis of L1 Retrotransposition and Somatic Mutation in the Human Brain

(2012) Gilad D. Evrony et al.   CELL

Extensive somatic L1 retrotransposition in colorectal tumors

(2012) S. Solyom et al.   GENOME RESEARCH

Transposable Elements in TDP-43-Mediated Neurodegenerative Disorders

(2012) Wanhe Li et al.   PLoS One

Landscape of Somatic Retrotransposition in Human Cancers

(2012) E. Lee et al.   SCIENCE

DNA methylation in repetitive elements and Alzheimer disease

(2011) V. Bollati et al.   BRAIN BEHAVIOR AND IMMUNITY

Retrotransposons: Mobile and mutagenic from conception to death

(2011) Geoffrey J. Faulkner   FEBS LETTERS

Retrotransposon activation contributes to fragile X premutation rCGG-mediated neurodegeneration

(2011) H. Tan et al.   HUMAN MOLECULAR GENETICS

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

(2011) Hiroki Kaneko et al.   NATURE

Somatic retrotransposition alters the genetic landscape of the human brain

(2011) J. Kenneth Baillie et al.   NATURE

Retrotransposition is associated with genome instability during chronological aging

(2011) P. H. Maxwell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retrotransposition of R2 elements in somatic nuclei during the early development of Drosophila

(2011) Michael T Eickbush et al.   Mobile DNA

Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

(2010) Renée Douville et al.   ANNALS OF NEUROLOGY

A LINE-1 component to human aging: Do LINE elements exact a longevity cost for evolutionary advantage?

(2010) Georges St. Laurent et al.   MECHANISMS OF AGEING AND DEVELOPMENT

L1 retrotransposition in neurons is modulated by MeCP2

(2010) Alysson R. Muotri et al.   NATURE

Hypomethylation of a LINE-1 Promoter Activates an Alternate Transcript of the MET Oncogene in Bladders with Cancer

(2010) Erika M. Wolff et al.   PLoS Genetics

Environmental influence on L1 retrotransposons in the adult hippocampus

(2009) Alysson R. Muotri et al.   HIPPOCAMPUS

Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity

(2009) Y. J. Crow et al.   HUMAN MOLECULAR GENETICS

Endogenous retroviral genes, Herpesviruses and gender in Multiple Sclerosis

(2009) Hervé Perron et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

L1 retrotransposition in human neural progenitor cells

(2009) Nicole G. Coufal et al.   NATURE

Incorporation of Y'-Ty1 cDNA Destabilizes Telomeres in Saccharomyces cerevisiae Telomerase-Negative Mutants

(2008) P. H. Maxwell et al.   GENETICS

An infectious progenitor for the murine IAP retrotransposon: Emergence of an intracellular genetic parasite from an ancient retrovirus

(2008) D. Ribet et al.   GENOME RESEARCH

The GLN Family of Murine Endogenous Retroviruses Contains an Element Competent for Infectious Viral Particle Formation

(2008) D. Ribet et al.   JOURNAL OF VIROLOGY