Article
Cell Biology
Andrzej K. Ciechanowicz, Katarzyna Sielatycka, Monika Cymer, Marta Skoda, Malwina Suszynska, Kamila Bujko, Mariusz Z. Ratajczak, Diane S. Krause, Magdalena Kucia
Summary: The study demonstrated that VSELs can differentiate into functional BASC and AT2 cells, indicating potential for developing effective cell therapy approaches for lung injury.
Article
Pharmacology & Pharmacy
Dongxin Chen, Huirong Tang, Hongchao Jiang, Lei Sun, Wenjuan Zhao, Feng Qian
Summary: This study investigated the effects of a selective CB1R agonist, ACPA, on pulmonary fibrosis induced by bleomycin (BLM). The results showed that ACPA treatment significantly improved survival rate and alleviated pulmonary fibrosis in BLM-treated mice. ACPA inhibited the expressions of extracellular matrix markers and diminished fibroblast migration triggered by TGF-beta. Furthermore, ACPA reduced the activation of TGF-beta-Smad2/3 signaling and decreased the expressions of downstream effector proteins in TGF-beta-challenged primary lung fibroblasts. These findings suggest that ACPA exhibits antifibrotic efficacy by targeting CB1R and inhibiting TGF-beta-Smad2/3 signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Masashi Kawami, Shinnosuke Takenaka, Yuri Kadekaru, Mizuki Akai, Takashi Konaka, Ryoko Yumoto, Mikihisa Takano
Summary: Studies suggest that EMT may occur before pulmonary fibrosis in alveolar epithelial cells, and miR-222 could be a potential marker for early prediction of pulmonary fibrosis.
Article
Biochemistry & Molecular Biology
Yu Ran Na, Jin Young Kim, Chang Ho Song, Mikyung Kim, Yen Thi Do, Tam Thuy Lu Vo, Eunsom Choi, Eunyoung Ha, Ji Hae Seo, So-Jin Shin
Summary: This study demonstrated the promising antitumor effects of AZD4547 in ovarian cancer cells, including inhibition of proliferation, induction of apoptosis, suppression of migration and invasion, reduction of stem cell activity and angiogenesis, as well as inhibition of in vivo tumor growth in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Ke Lv, Mingyue Li, Chenghong Sun, Yu Miao, Yan Zhang, Yang Liu, Jianshuang Guo, Qing Meng, Jingchun Yao, Guimin Zhang, Jing Li
Summary: This study investigated the effects of Jingfang granules on acute lung injury and its mechanisms. The results showed that Jingfang granules can attenuate pulmonary injury and inflammation by reducing the recruitment and activation of alveolar macrophages through the CD200-CD200R immunoregulatory signal axis. This provides an experimental basis for the clinical application of Jingfang granules in COVID-19.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Chunjie Ding, Shan Hong, Miao Zhang, Yunzhe Sun, Ning Li, Jing Zhang, Lan Ma, Linqiang Tian, Wenjie Ren, Lin Zhang, Sanqiao Yao
Summary: In this study, an in vitro blast lung injury model was established using alveolar epithelial cells stimulated with blast waves of different intensities. The model mimics injuries caused by gas explosions in coal mines, showing decreases in cell viability, along with inflammatory responses consistent with human blast-induced pulmonary injuries.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Rheumatology
Keishi Etori, Shigeru Tanaka, Jun Tamura, Koto Hattori, Shin-Ichiro Kagami, Junichi Nakamura, Seiji Ohtori, Hiroshi Nakajima
Summary: This study found that FGFR1 marks terminal effector Tph cells in patients with RA, suggesting its important role in the pathogenesis of RA.
Article
Medicine, General & Internal
Elena Lopez-Rodriguez, Gemma Gay-Jordi, Lars Knudsen, Matthias Ochs, Anna Serrano-Mollar
Summary: In idiopathic pulmonary fibrosis (IPF), intratracheal administration of alveolar epithelial type II cells (AE2C) has been shown to reverse fibrosis, but further research is needed to determine if this involves any improvement in alveolar dynamics.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Fen Liu, Wei Peng, Jiaquan Chen, Zeyao Xu, Rong Jiang, Qiang Shao, Ning Zhao, Kejian Qian
Summary: The study revealed that AEC-derived exosomes activate AMs and induce pulmonary inflammation mediated by miR-92a-3p, indicating a novel disease mechanism.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Jia-Xi Duan, Xin-Xin Guan, Hui-Hui Yang, Wen-Xiu Mei, Ping Chen, Jia-Hao Tao, Qing Li, Yong Zhou
Summary: The study demonstrates that VIP attenuates bleomycin-induced pulmonary fibrosis in mice through restoring autophagy in alveolar epithelial cells, with anti-epithelial-mesenchymal transition (EMT) effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Michal Sobecki, Jing Chen, Ewelina Krzywinska, Shunmugam Nagarajan, Zheng Fan, Eric Nelius, Josep M. Monne Rodriguez, Frauke Seehusen, Amro Hussein, Greta Moschini, Edries Y. Hajam, Ravi Kiran, Dagmar Gotthardt, Julien Debbache, Cecile Badoual, Tatsuyuki Sato, Takayuki Isagawa, Norihiko Takeda, Corinne Tanchot, Eric Tartour, Achim Weber, Sabine Werner, Johannes Loffing, Lukas Sommer, Veronika Sexl, Christian Muenz, Carol Feghali-Bostwick, Elena Pachera, Oliver Distler, Jess Snedeker, Colin Jamora, Christian Stockmann
Summary: This study demonstrates that immunotherapy targeting fibrogenic cells could be a potential approach to treat fibrosis.
Review
Cell Biology
Guihong Liu, Tao Chen, Zhenyu Ding, Yang Wang, Yuquan Wei, Xiawei Wei
Summary: The FGF-FGFR signaling pathway and the VEGF-VEGFR signaling pathway play important roles in the treatment of tumors, and inhibitors targeting these two pathways can optimize therapeutic effects and expand the antitumor range. In addition, biomarkers should be developed in the future to predict efficacy, and combination with immune checkpoint inhibitors is a promising direction.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Kai-Wei Chang, Xiang Zhang, Shih-Chao Lin, Yu-Chao Lin, Chia-Hsiang Li, Ivan Akhrymuk, Sheng-Hao Lin, Chi-Chien Lin
Summary: Atractylodin attenuates TGF-beta 1-induced EMT in A549 cells and bleomycin-induced pulmonary fibrosis in mice. This suggests that Atractylodin may have therapeutic potential for treating IPF by targeting EMT pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rene Roy, Ayed Allawzi, Nana Burns, Christina Sul, Victoria Rubio, Jessica Graham, Kurt Stenmark, Eva Nozik, Rubin Tuder, Christine Vohwinkel
Summary: This study reveals that lactate produced by alveolar type II cells (ATII) in acute lung injury (ALI) can shift alveolar macrophages (AM) towards an anti-inflammatory phenotype, thereby mitigating excessive inflammation.
Article
Immunology
Ping Zhan, Xue Lu, Zhao Li, Wen-Jing Wang, Kun Peng, Nan-Nan Liang, Yan Wang, Jian Li, Lin Fu, Hui Zhao, De-Xiang Xu, Zhu-Xia Tan
Summary: This study explored the role of mitochondrial reactive oxygen species (ROS) in bleomycin-induced acute lung injury (ALI) and ferroptosis of pulmonary epithelial cells. Mitochondria-targeted antioxidants may serve as potential therapeutic agents for bleomycin-induced ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Robert B. Hamanaka, Gokhan M. Mutlu
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Article
Biology
Kaitlyn A. Sun, Yan Li, Angelo Y. Meliton, Parker S. Woods, Lucas M. Kimmig, Rengul Cetin-Atalay, Robert B. Hamanaka, Gokhan M. Mutlu
Review
Biochemistry & Molecular Biology
Robert B. Hamanaka, Gokhan M. Mutlu
Summary: Fibrosis is a pathological condition characterized by excessive deposition of extracellular matrix and chronic scaring. Idiopathic pulmonary fibrosis (IPF) is a devastating disease with a pressing need for novel therapeutic strategies. Myofibroblasts, key cells responsible for matrix deposition in fibrotic diseases, exhibit metabolic changes associated with their function, offering potential targets for new therapies.
Article
Critical Care Medicine
Robinder G. Khemani, Jessica T. Lee, David Wu, Edward J. Schenck, Margaret M. Hayes, Patricia A. Kritek, Gokhan M. Mutlu, Hayley B. Gershengorn, Remi Coudroy
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Editorial Material
Biochemistry & Molecular Biology
Robert Guzy, Elizabeth F. Redente
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Letter
Biochemistry & Molecular Biology
David Wu, Tzu-Han Lee, Ru-Ting Huang, Robert D. Guzy, Nathan Schoettler, Ayodeji Adegunsoye, Jeffrey Mueller, Aliya Husain, Anne I. Sperling, Gokhan M. Mutlu, Yun Fang
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Robert B. Hamanaka, Gokhan M. Mutlu
Summary: Fibrosis is a pathological condition resulting from abnormal wound healing responses, contributing to significant mortality worldwide. Metabolic reprogramming plays a crucial role in the pathogenic phenotype of fibrotic diseases, particularly in myofibroblast differentiation. Understanding metabolic changes and amino acid synthesis is essential for developing novel therapeutic approaches.
Article
Pathology
Phillip McMullen, Peter Pytel, Alexis Snyder, Heather Smith, Jasmine Vickery, James Brainer, Robert Guzy, David Wu, Nathan Schoettler, Ayodeji Adegunsoye, Anne Sperling, John Hart, Lindsay Alpert, Anthony Chang, Sandeep Gurbuxani, Thomas Krausz, Aliya N. Husain, Jeffrey Mueller
Summary: Autopsies of COVID-19 patients have revealed clinical and histologic features similar to fatal cases of seasonal influenza, with overlapping pathological findings between the two diseases. There were no significant differences in inflammatory infiltrates at sites of acute lung injury between COVID-19 and influenza cases. The study emphasizes the relatively nonspecific clinical features and shared pathological changes between severe COVID-19 and influenza cases, while also cautioning about ancillary methods of viral detection.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2021)
Article
Respiratory System
Kavitha Selvan, Gokhan Mutlu
Summary: There has been a rise in secondary bacterial and fungal infections associated with COVID-19, with reports of rare Geotrichum infection in immunocompetent hosts. Clinical suspicion is crucial for detecting invasive fungal infections, like Geotrichum, in patients with SARS-CoV-2, especially in those with compromised immune systems.
TUBERKULOZ VE TORAKS-TUBERCULOSIS AND THORAX
(2021)
Editorial Material
Biochemistry & Molecular Biology
Robert D. Guzy, Seth Bollenbecker, Stefanie Krick
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Robert B. Hamanaka, Gokhan M. Mutlu
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Rengul Cetin-Atalay, Angelo Y. Meliton, Cevher Ozcan, Parker S. Woods, Kaitlyn A. Sun, Yun Fang, Robert B. Hamanaka, Goekhan M. Mutlu
Summary: The study found that Hmox2(-/-) mice exhibit endothelial cell activation and transcriptomic and functional changes consistent with heart failure.
Article
Cell Biology
Xiaojia Huang, Xianming Zhang, Narsa Machireddy, Colin E. Evans, Shawn D. Trewartha, Guochang Hu, Yun Fang, Goekhan M. Mutlu, David Wu, You-Yang Zhao
Summary: Aging impairs endothelial regeneration and vascular repair, leading to increased mortality in acute respiratory distress syndrome (ARDS) after sepsis challenge. Reactivation of the FoxM1 gene or treatment with the DNA demethylating agent decitabine promotes endothelial regeneration, normalizes vascular repair and resolution of inflammation, and improves survival in aged mice. FOXM1 induction is impaired in elderly patients with ARDS, suggesting that targeting FoxM1-mediated endothelial regeneration may be a potential therapy for this population.
SCIENCE TRANSLATIONAL MEDICINE
(2023)