Synaptotagmin-1 interacts with PI(4,5)P2 to initiate synaptic vesicle docking in hippocampal neurons

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Synaptotagmin-1 binds to PIP2-containing membrane but not to SNAREs at physiological ionic strength

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All three components of the neuronal SNARE complex contribute to secretory vesicle docking

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Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation

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