Article
Medicine, Research & Experimental
Caspar Schiffers, Cheryl van de Wetering, Robert A. Bauer, Aida Habibovic, Milena Hristova, Christopher M. Dustin, Sara Lambrichts, Pamela M. Vacek, Emiel F. M. Wouters, Niki L. Reynaert, Albert van der Vliet
Summary: The downregulation of DUOX1 in the airways of patients with Chronic Obstructive Pulmonary Disease (COPD) may contribute to the pathogenesis of COPD, leading to airway remodeling and emphysema. Animal studies also demonstrate that Duox1 deficiency exacerbates lung pathology induced by smoke exposure.
Article
Chemistry, Medicinal
Jin-Hwa Kim, Jeong-Won Kim, Chang-Yeop Kim, Ji-Soo Jeong, Je-Won Ko, Tae-Won Kim
Summary: This study aimed to explore the protective mechanisms of green tea extract (GTE) on cigarette smoke condensate (CSC)-induced emphysema by reducing macrophage-induced protease expression. Results showed that GTE significantly reduced macrophage counts and emphysematous lesions in CSC-exposed mice. Furthermore, GTE suppressed CSC-induced ERK/AP-1 phosphorylation and MMP-9 expression. These findings suggest that GTE can be used as a supplementary agent for preventing emphysema progression in COPD patients.
PHYTOTHERAPY RESEARCH
(2023)
Article
Respiratory System
David A. Skerrett-Byrne, Elizabeth G. Bromfield, Heather C. Murray, M. Fairuz B. Jamaluddin, Andrew G. Jarnicki, Michael Fricker, Ama T. Essilfie, Bernadette Jones, Tatt J. Haw, Daniel Hampsey, Amanda L. Anderson, Brett Nixon, Rodney J. Scott, Peter A. B. Wark, Matthew D. Dun, Philip M. Hansbro
Summary: The study utilized proteomics to uncover major protein changes associated with the pathogenesis and disease progression of COPD, including alterations in RNA biosynthesis, inflammatory responses, mitochondrial function, and oxidative stress. These changes provide insight for developing new effective treatment strategies.
Article
Immunology
Xiangming Liu, Yiming Ma, Lijuan Luo, Zihang Zeng, Dandan Zong, Yan Chen
Summary: Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation and lung parenchymal cell apoptosis, with cigarette smoke being the major risk factor. In this study, taxifolin (TAX) was found to significantly alleviate cigarette smoke-induced inflammation and apoptosis in vivo and in vitro. TAX treatment suppressed the elevated levels of IL-1 beta, IL-6, and TNF-alpha, and decreased the ratios of p-i kappa B to i kappa B and p-p65 to p65. Additionally, TAX exhibited antiapoptotic effects by reversing the changes in Bax, CCP3, and Bcl-2 levels induced by cigarette smoke. These findings highlight the potential of TAX in improving COPD pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Charlotte de Fays, Vincent Geudens, Iwein Gyselinck, Pieterjan Kerckhof, Astrid Vermaut, Tinne Goos, Marie Vermant, Hanne Beeckmans, Janne Kaes, Jan Van Slambrouck, Yousry Mohamady, Lynn Willems, Lucia Aversa, Emanuela E. Cortesi, Charlotte Hooft, Gitte Aerts, Celine Aelbrecht, Stephanie Everaerts, John E. McDonough, Laurens J. De Sadeleer, Sophie Gohy, Jerome Ambroise, Wim Janssens, Laurens J. Ceulemans, Dirk Van Raemdonck, Robin Vos, Tillie L. Hackett, James C. Hogg, Naftali Kaminski, Ghislaine Gayan-Ramirez, Charles Pilette, Bart M. Vanaudenaerde
Summary: This study investigated the mucosal immune defense in control and end-stage COPD lungs, and found dysregulation in mucosal defense, with decreased defensins and increased mucus and IgA responses. The study also observed CD8+ T-cell accumulation in mild emphysema zones and adaptive Th and B cell activation in areas with more advanced tissue destruction. The study suggests that innate immune alterations in COPD occur early in the tissue destruction process, affecting both the alveoli and the terminal bronchioles, before the onset of an adaptive immune response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Sun Young Jung, Gun-Dong Kim, Dae Woon Choi, Dong-Uk Shin, Ji-Eun Eom, Seung Yong Kim, Ok Hee Chai, Hyun-Jin Kim, So-Young Lee, Hee Soon Shin
Summary: The study found that Epilobium species extract can inhibit inflammatory cell recruitment and symptoms in COPD mice, as well as attenuate inflammatory gene expression by suppressing MAPKs and NF kappa B activity. Additionally, identified phytochemical constituents of Epilobium species extract showed anti-inflammatory effects.
Article
Immunology
Lijing Wang, Qiong Chen, Qiao Yu, Jian Xiao, Hongjun Zhao
Summary: In this study, it was found that exosomes derived from cigarette smoke extract-treated mouse airway epithelial cells promoted M1 macrophage polarization by upregulating TREM-1 expression, thereby aggravating the development of COPD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Cell Biology
John W. Hanrahan, Asmahan Abu-Arish, Francis H. Wong, Mark J. Turner, Graeme W. Carlile, David Y. Thomas, Andre M. Cantin
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of death, with cigarette smoke being the main risk factor. COPD shares similarities with cystic fibrosis (CF), particularly in terms of inflammation, mucus obstruction, and infection. Understanding the effects of cigarette smoke on CFTR function may lead to the development of novel therapeutics for reducing the progression and severity of COPD.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Critical Care Medicine
Sandeep Bodduluri, Abhilash Kizhakke Puliyakote, Arie Nakhmani, Jean-Paul Charbonnier, Joseph M. Reinhardt, Surya P. Bhatt
Summary: The study analyzed airway remodeling in COPD patients by examining the ratio of airway luminal surface area to volume, which indicates airway narrowing and loss. The results showed that airway SA/V is associated with disease severity, lung function decline, respiratory quality, and survival in COPD patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Natalia Pereira da Silva Araujo, Natalia Alves de Matos, Michel Oliveira, Ana Beatriz Farias de Souza, Thalles de Freitas Castro, Pedro Alves Machado-Junior, Debora Maria Soares de Souza, Andre Talvani, Silvia Dantas Cangussu, Rodrigo Cunha Alvim de Menezes, Frank Silva Bezerra
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of disability and mortality worldwide, with cigarette smoke playing a key role in its development. Quercetin may have potential as a preventive agent for smoke-induced pulmonary emphysema.
Article
Biochemistry & Molecular Biology
Yunchao Su, Weihong Han, Anita Kovacs-Kasa, Alexander D. Verin, Laszlo Kovacs
Summary: The study shows that HDAC6 expression is upregulated in patients with COPD and in a COPD animal model. Cigarette smoke extract, PDGF, and IL-6 increase protein levels and activation of HDAC6 in bronchial and pulmonary smooth muscle cells, leading to collagen synthesis and cell proliferation. Pharmacological inhibition of HDAC6 prevents airway and vascular remodeling in COPD.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Marija Gredic, Isabel Blanco, Gabor Kovacs, Zsuzsanna Helyes, Peter Ferdinandy, Horst Olschewski, Joan Albert Barbera, Norbert Weissmann
Summary: This article summarizes the pathophysiology and treatment options for PH in COPD patients, pointing out that current research still does not fully understand its underlying mechanisms, and some of the treatment methods tested in clinical settings have not been effective. Preclinical studies have proposed some treatment approaches.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Critical Care Medicine
Javier Sevilla-Montero, David Labrousse-Arias, Cintia Fernandez-Perez, Laura Fernandez-Blanco, Bianca Barreira, Gema Mondejar-Parreno, Elvira Alfaro-Arnedo, Iciar P. Lopez, Sandra Perez-Rial, German Peces-Barba, Jose G. Pichel, Victor Ivo Peinado, Angel Cogolludo, Maria J. Calzada
Summary: Cigarette smoke extract directly promotes pulmonary arterial remodeling by inducing cell senescence and secretion of inflammatory molecules, leading to increased proliferative potential of nonexposed cells, which can be reversed by antioxidants. Additionally, cigarette smoke extract affects cell contractility and dysregulates the Kv7.4 channel, impairing vasoconstriction and vasodilation responses. The levels of Kv7.4 channel were found to be diminished in the lungs of smoke-exposed mice, smokers, and patients with COPD, suggesting a potential target for novel therapies.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Plant Sciences
Xiangming Liu, Yiming Ma, Lijuan Luo, Dandan Zong, Herui Li, Zihang Zeng, Yanan Cui, Weiwei Meng, Yan Chen
Summary: DHQ significantly reverses cigarette smoke-induced ferroptosis via a Nrf2-dependent signaling pathway, exerting protective effects in both in vivo mouse models and in vitro cell cultures.
Article
Biochemistry & Molecular Biology
Megan E. Huber, Emily Larson, Taylor N. Lust, Chelsea M. Heisler, Melanie J. Harriff
Summary: Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation, increased infiltration of CD81 T lymphocytes, and infection-driven exacerbations. The role of lung-resident mucosal-associated invariant T (MAIT) cells in COPD pathology is unclear. This study found that MAIT cell activation is dysregulated in response to cigarette smoke and COPD, potentially contributing to inflammation and impaired bacterial recognition, leading to microbial persistence and COPD exacerbations.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)