A novel age-informed approach for genetic association analysis in Alzheimer’s disease

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

(2021) Daniel Taliun et al.   NATURE

Interpretation of risk loci from genome-wide association studies of Alzheimer's disease

(2020) Shea J Andrews et al.   LANCET NEUROLOGY

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4

(2020) Michael E. Belloy et al.   JAMA Neurology

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease

(2020) Ruinan Shen et al.   Translational Neurodegeneration

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

(2020) Solveig K. Sieberts et al.   Scientific Data

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Polygenic risk and hazard scores for Alzheimer's disease prediction

(2019) Ganna Leonenko et al.   Annals of Clinical and Translational Neurology

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Cox regression increases power to detect genotype-phenotype associations in genomic studies using the electronic health record

(2019) Jacob J. Hughey et al.   BMC GENOMICS

Rab10 Phosphorylation is a Prominent Pathological Feature in Alzheimer’s Disease

(2018) Tingxiang Yan et al.   JOURNAL OF ALZHEIMERS DISEASE

The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study

(2018) Sven J van der Lee et al.   LANCET NEUROLOGY

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies

(2018) Caterina Giacomini et al.   Acta Neuropathologica Communications

Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

(2018) Joshua C. Bis et al.   MOLECULAR PSYCHIATRY

gwasurvivr: an R package for genome-wide survival analysis

(2018) Abbas A Rizvi et al.   BIOINFORMATICS

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

RAB10: an Alzheimer’s disease resilience locus and potential drug target

(2018) Justina Tavana et al.   Clinical Interventions in Aging

Author Correction: Imaging and clinical data archive for head and neck squamous cell carcinoma patients treated with radiotherapy

(2018) Aaron J. Grossberg et al.   Scientific Data

A comparison of Cox and logistic regression for use in genome-wide association studies of cohort and case-cohort design

(2017) James R Staley et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Efficient Semiparametric Inference Under Two-Phase Sampling, With Applications to Genetic Association Studies

(2017) Ran Tao et al.   JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION

Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience

(2017) Perry G. Ridge et al.   Genome Medicine

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

(2017) Rahul S. Desikan et al.   PLOS MEDICINE

Two-phase outcome-dependent studies for failure times and testing for effects of expensive covariates

(2016) J. F. Lawless   LIFETIME DATA ANALYSIS

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Next-generation genotype imputation service and methods

(2016) Sayantan Das et al.   NATURE GENETICS

Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases

(2016) Mariet Allen et al.   Scientific Data

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

The age factor in Alzheimer’s disease

(2015) Rita Guerreiro et al.   Genome Medicine

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

Conducting Meta-Analyses inRwith themetaforPackage

(2015) Wolfgang Viechtbauer   Journal of Statistical Software

Effects of traumatic brain injury and posttraumatic stress disorder on Alzheimer's disease in veterans, using the Alzheimer's Disease Neuroimaging Initiative

(2014) Michael W. Weiner et al.   Alzheimers & Dementia

Genetic Association Analysis under Complex Survey Sampling: The Hispanic Community Health Study/Study of Latinos

(2014) Dan-Yu Lin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

JIP1 Mediates Anterograde Transport of Rab10 Cargos during Neuronal Polarization

(2014) C.-Y. Deng et al.   JOURNAL OF NEUROSCIENCE

A Paired RNAi and RabGAP Overexpression Screen Identifies Rab11 as a Regulator of β-Amyloid Production

(2014) Vinod Udayar et al.   Cell Reports

Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease

(2014) Adam C. Naj et al.   JAMA Neurology

Abundant kif21b is associated with accelerated progression in neurodegenerative diseases

(2014) Karim L Kreft et al.   Acta Neuropathologica Communications

Improved ancestry inference using weights from external reference panels

(2013) Chia-Yen Chen et al.   BIOINFORMATICS

Overview and Findings from the Rush Memory and Aging Project

(2013) David A. Bennett et al.   Current Alzheimer Research

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors

(2013) Meng-meng Fu et al.   JOURNAL OF CELL BIOLOGY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Selection for Translation Efficiency on Synonymous Polymorphisms in Recent Human Evolution

(2011) Yedael Y. Waldman et al.   Genome Biology and Evolution

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

The Alzheimer's Disease Neuroimaging Initiative: Progress report and future plans

(2010) Michael W. Weiner et al.   Alzheimers & Dementia

Genome-wide Association Study Implicates a Chromosome 12 Risk Locus for Late-Onset Alzheimer Disease

(2009) Gary W. Beecham et al.   AMERICAN JOURNAL OF HUMAN GENETICS

AddNeuroMed-The European Collaboration for the Discovery of Novel Biomarkers for Alzheimer's Disease

(2009) Simon Lovestone et al.   Annals of the New York Academy of Sciences

Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study

(2008) Joseph H. Lee   ARCHIVES OF NEUROLOGY

Impact of point-mutations on the hybridization affinity of surface-bound DNA/DNA and RNA/DNA oligonucleotide-duplexes: Comparison of single base mismatches and base bulges

(2008) Thomas Naiser et al.   BMC BIOTECHNOLOGY