Inheritable testicular metabolic memory of high-fat diet causes transgenerational sperm defects in mice

Diet during early life defines testicular lipid content and sperm quality in adulthood

(2020) Luis Crisóstomo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

(2020) Gemma C Sharp et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Non-genetic inheritance via the male germline in mammals

(2019) Faye A. Baxter et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

A switch from high-fat to normal diet does not restore sperm quality but prevents metabolic syndrome

(2019) Luís Crisóstomo et al.   REPRODUCTION

Human sperm displays rapid responses to diet

(2019) Daniel Nätt et al.   PLOS BIOLOGY

Alterations in sperm DNA methylation, non-coding RNA and histone retention associate with DDT-induced epigenetic transgenerational inheritance of disease

(2018) Michael K. Skinner et al.   Epigenetics & Chromatin

Transgenerational Epigenetic Inheritance

(2018) Ana Bošković et al.   Annual Review of Genetics

Senescence and declining reproductive potential: Insight into molecular mechanisms through testicular metabolomics

(2018) Ivana Jarak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice

(2018) Adam J. Watkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intergenerational and transgenerational epigenetic inheritance in animals

(2018) Marcos Francisco Perez et al.   NATURE CELL BIOLOGY

Obesity, male infertility, and the sperm epigenome

(2017) James R. Craig et al.   FERTILITY AND STERILITY

Diabetes-induced hyperglycemia impairs male reproductive function: a systematic review

(2017) Constanze C Maresch et al.   HUMAN REPRODUCTION UPDATE

Temporal trends in sperm count: a systematic review and meta-regression analysis

(2017) Hagai Levine et al.   HUMAN REPRODUCTION UPDATE

Restoration of metabolic health by decreased consumption of branched-chain amino acids

(2017) Nicole E. Cummings et al.   JOURNAL OF PHYSIOLOGY-LONDON

From the Cover: Metabolomics Reveals a Role of Betaine in Prenatal DBP Exposure-Induced Epigenetic Transgenerational Failure of Spermatogenesis in Rats

(2017) Beilei Yuan et al.   TOXICOLOGICAL SCIENCES

Transgenerational inheritance of susceptibility to diabetes-induced male subfertility

(2017) Gabriela Pavlinkova et al.   Scientific Reports

The effects of paternal high-fat diet exposure on offspring metabolism with epigenetic changes in the mouse adiponectin and leptin gene promoters

(2016) Hisashi Masuyama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity

(2016) Jennifer E. Cropley et al.   Molecular Metabolism

Leptin modulates human Sertoli cells acetate production and glycolytic profile: a novel mechanism of obesity-induced male infertility?

(2015) Ana D. Martins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

I’m Eating for Two: Parental Dietary Effects on Offspring Metabolism

(2015) Oliver J. Rando et al.   CELL

Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis

(2015) Jared M. Campbell et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders

(2015) Valérie Grandjean et al.   Scientific Reports

Effect of increasing paternal body mass index on pregnancy and live birth rates in couples undergoing intracytoplasmic sperm injection

(2014) M. Umul et al.   ANDROLOGIA

Paternal high-fat diet consumption induces common changes in the transcriptomes of retroperitoneal adipose and pancreatic islet tissues in female rat offspring

(2014) Sheau-Fang Ng et al.   FASEB JOURNAL

Obese father’s metabolic state, adiposity, and reproductive capacity indicate son’s reproductive health

(2014) Nicole O. McPherson et al.   FERTILITY AND STERILITY

The Warburg Effect Revisited-Lesson from the Sertoli Cell

(2014) Pedro F. Oliveira et al.   MEDICINAL RESEARCH REVIEWS

Metabolomic profiles delineate the potential role of glycine in gold nanorod-induced disruption of mitochondria and blood–testis barrier factors in TM-4 cells

(2014) Bo Xu et al.   Nanoscale

Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress

(2013) Luís Rato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Developmental Programming by Maternal Insulin Resistance: Hyperinsulinemia, Glucose Intolerance, and Dysregulated Lipid Metabolism in Male Offspring of Insulin-Resistant Mice

(2013) E. Isganaitis et al.   DIABETES

Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content

(2013) Tod Fullston et al.   FASEB JOURNAL

Newborns of obese parents have altered DNA methylation patterns at imprinted genes

(2013) A Soubry et al.   INTERNATIONAL JOURNAL OF OBESITY

Bidirectional communication between oocytes and ovarian follicular somatic cells is required for meiotic arrest of mammalian oocytes

(2013) K. Wigglesworth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-energy diets may induce a pre-diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters

(2013) L. Rato et al.   Andrology

Insulin resistance and the metabolism of branched-chain amino acids

(2013) Jingyi Lu et al.   Frontiers of Medicine

Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille, France

(2012) Cendrine Geoffroy-Siraudin et al.   ASIAN JOURNAL OF ANDROLOGY

In vitro cultured human Sertoli cells secrete high amounts of acetate that is stimulated by 17β-estradiol and suppressed by insulin deprivation

(2012) Marco G. Alves et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The risk of maternal obesity to the long-term health of the offspring

(2012) James R. O'Reilly et al.   CLINICAL ENDOCRINOLOGY

Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice

(2012) T. Fullston et al.   HUMAN REPRODUCTION

Insulin resistance and the metabolism of branched-chain amino acids in humans

(2011) María M. Adeva et al.   AMINO ACIDS

Substrate selection in hearts subjected to ischemia/reperfusion: role of cardioplegic solutions and gender

(2011) Marco G. Alves et al.   NMR IN BIOMEDICINE

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse

(2009) Owen P. McGuinness et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Intergenerational influences on childhood body mass index: the effect of parental body mass index trajectories

(2008) Leah Li et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Identification of a novel Leucine-rich repeat protein and candidate PP1 regulatory subunit expressed in developing spermatids

(2008) Rong Wang et al.   BMC CELL BIOLOGY