Intergenerational and transgenerational epigenetic inheritance in animals

Identification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C. elegans Germline

(2018) En-Zhi Shen et al.   CELL

Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life

(2018) Moran Yassour et al.   Cell Host & Microbe

A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans

(2018) Wen Tang et al.   DEVELOPMENTAL CELL

ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals

(2018) Takao Ishidate et al.   MOLECULAR CELL

Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

(2018) Yunfang Zhang et al.   NATURE CELL BIOLOGY

tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner

(2018) Canan Kuscu et al.   RNA

The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes

(2018) Donglei Zhang et al.   SCIENCE

The Coding Regions of Germline mRNAs Confer Sensitivity to Argonaute Regulation in C. elegans

(2018) Meetu Seth et al.   Cell Reports

RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment

(2018) Eva Benito et al.   Cell Reports

The Memory of Environmental Chemical Exposure in C. elegans Is Dependent on the Jumonji Demethylases jmjd-2 and jmjd-3/utx-1

(2018) Jessica Camacho et al.   Cell Reports

Transgenerational Sterility of Piwi Mutants Represents a Dynamic Form of Adult Reproductive Diapause

(2018) Bree Heestand et al.   Cell Reports

Effect of Larval Nutrition on Maternal mRNA Contribution to the Drosophila Egg

(2018) Amanda E. Crofton et al.   G3-Genes Genomes Genetics

Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress

(2018) David A. Dickson et al.   Translational Psychiatry

Natural Genetic Variation in a Multigenerational Phenotype in C. elegans

(2018) Lise Frézal et al.   CURRENT BIOLOGY

Small RNAs Gained during Epididymal Transit of Sperm Are Essential for Embryonic Development in Mice

(2018) Colin C. Conine et al.   DEVELOPMENTAL CELL

Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance

(2018) Gang Wan et al.   NATURE

Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis

(2018) Tomoko M. Tabuchi et al.   Nature Communications

The RNAi Inheritance Machinery of Caenorhabditis elegans

(2017) George Spracklin et al.   GENETICS

Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan

(2017) Shuo Han et al.   NATURE

Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila

(2017) Filippo Ciabrelli et al.   NATURE GENETICS

AMPK blocks starvation-inducible transgenerational defects inCaenorhabditis elegans

(2017) Emilie Demoinet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenerational transmission of environmental information in C. elegans

(2017) Adam Klosin et al.   SCIENCE

piRNA Biogenesis in Drosophila melanogaster

(2017) Xiawei Huang et al.   TRENDS IN GENETICS

Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in Caenorhabditis elegans

(2017) Natallia Kalinava et al.   Epigenetics & Chromatin

Environmental stresses induce transgenerationally inheritable survival advantages via germline-to-soma communication in Caenorhabditis elegans

(2017) Saya Kishimoto et al.   Nature Communications

The RNAi Inheritance Machinery of Caenorhabditis elegans

(2017) George Spracklin et al.   GENETICS

Impaired DNA replication derepresses chromatin and generates a transgenerationally inherited epigenetic memory

(2017) Adam Klosin et al.   Science Advances

Transgenerational programming of longevity and reproduction by post-eclosion dietary manipulation in Drosophila

(2016) Brian Xia et al.   Aging-US

An Abundant Class of Non-coding DNA Can Prevent Stochastic Gene Silencing in the C. elegans Germline

(2016) Christian Frøkjær-Jensen et al.   CELL

A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans

(2016) Leah Houri-Ze’evi et al.   CELL

Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans

(2016) Ida Donkin et al.   Cell Metabolism

Mechanisms, timescales and principles of trans-generational epigenetic inheritance in animals

(2016) Adam Klosin et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Diet-induced extinctions in the gut microbiota compound over generations

(2016) Erica D. Sonnenburg et al.   NATURE

Epigenetic germline inheritance of diet-induced obesity and insulin resistance

(2016) Peter Huypens et al.   NATURE GENETICS

Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications

(2016) Qi Chen et al.   NATURE REVIEWS GENETICS

A transgenerational role of the germline nuclear RNAi pathway in repressing heat stress-induced transcriptional activation in C. elegans

(2016) Julie Zhouli Ni et al.   Epigenetics & Chromatin

Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance

(2016) Jonathan D. Hibshman et al.   PLoS Genetics

Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study

(2016) Adelheid Soubry et al.   Clinical Epigenetics

When two obese parents are worse than one! Impacts on embryo and fetal development

(2015) N. O. McPherson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

I’m Eating for Two: Parental Dietary Effects on Offspring Metabolism

(2015) Oliver J. Rando et al.   CELL

The Nrde Pathway Mediates Small-RNA-Directed Histone H3 Lysine 27 Trimethylation in Caenorhabditis elegans

(2015) Hui Mao et al.   CURRENT BIOLOGY

Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome

(2015) Jeremy M. Shea et al.   DEVELOPMENTAL CELL

Transgenerational Effects of Early Life Starvation on Growth, Reproduction, and Stress Resistance in Caenorhabditis elegans

(2015) M. A. Jobson et al.   GENETICS

What Do You Mean, “Epigenetic”?

(2015) Carrie Deans et al.   GENETICS

Antiviral RNA Interference against Orsay Virus Is neither Systemic nor Transgenerational in Caenorhabditis elegans

(2015) Alyson Ashe et al.   JOURNAL OF VIROLOGY

RNA-mediated epigenetic regulation of gene expression

(2015) Daniel Holoch et al.   NATURE REVIEWS GENETICS

Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress

(2015) Ali B. Rodgers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Double-stranded RNA made inC. elegansneurons can enter the germline and cause transgenerational gene silencing

(2015) Sindhuja Devanapally et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Disruption of histone methylation in developing sperm impairs offspring health transgenerationally

(2015) K. Siklenka et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

Tertiary siRNAs Mediate Paramutation in C. elegans

(2015) Alexandra Sapetschnig et al.   PLoS Genetics

What Do You Mean, “Epigenetic”?

(2015) Carrie Deans et al.   GENETICS

Cytosine DNA Methylation Is Found in Drosophila melanogaster but Absent in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Other Yeast Species

(2014) Floriana Capuano et al.   ANALYTICAL CHEMISTRY

Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity

(2014) Anita Öst et al.   CELL

Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans

(2014) Oded Rechavi et al.   CELL

Transgenerational Epigenetic Inheritance: Myths and Mechanisms

(2014) Edith Heard et al.   CELL

In Utero Undernutrition in Male Mice Programs Liver Lipid Metabolism in the Second-Generation Offspring Involving Altered Lxra DNA Methylation

(2014) Débora Martínez et al.   Cell Metabolism

Reduction in maternalPolycomblevels contributes to transgenerational inheritance of a response to toxic stress in flies

(2014) Shay Stern et al.   JOURNAL OF PHYSIOLOGY-LONDON

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

(2014) Katharina Gapp et al.   NATURE NEUROSCIENCE

The role of genomic imprinting in biology and disease: an expanding view

(2014) Jo Peters   NATURE REVIEWS GENETICS

Small RNAs break out: the molecular cell biology of mobile small RNAs

(2014) Peter Sarkies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impact of nuclear Piwi elimination on chromatin state in Drosophila melanogaster ovaries

(2014) Mikhail S. Klenov et al.   NUCLEIC ACIDS RESEARCH

Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells: Possible Transport by Exosomes

(2014) Cristina Cossetti et al.   PLoS One

Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals

(2014) Yanchang Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations

(2014) A. Sakaguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

(2014) E. J. Radford et al.   SCIENCE

H3K27me and PRC2 transmit a memory of repression across generations and during development

(2014) L. J. Gaydos et al.   SCIENCE

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

(2014) Paula Dominguez-Salas et al.   Nature Communications

Reduced Insulin/IGF-1 Signaling Restores Germ Cell Immortality to Caenorhabditis elegans Piwi Mutants

(2014) Matt Simon et al.   Cell Reports

A Histone Methylation Network Regulates Transgenerational Epigenetic Memory in C. elegans

(2014) Eric L. Greer et al.   Cell Reports

Heritable Transmission of Stress Resistance by High Dietary Glucose in Caenorhabditis elegans

(2014) Arnaud Tauffenberger et al.   PLoS Genetics

piRNA clusters and open chromatin structure

(2014) Soichiro Yamanaka et al.   Mobile DNA

Delayed development induced by toxicity to the host can be inherited by a bacterial-dependent, transgenerational effect

(2014) Yael Fridmann-Sirkis et al.   Frontiers in Genetics

H3K4 demethylase activities repress proliferative and postmitotic aging

(2013) Stacy M. Alvares et al.   AGING CELL

Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine

(2013) MVE Veenendaal et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development

(2013) Nisha Padmanabhan et al.   CELL

The C. elegans CSR-1 Argonaute Pathway Counteracts Epigenetic Silencing to Promote Germline Gene Expression

(2013) Meetu Seth et al.   DEVELOPMENTAL CELL

Protection of Germline Gene Expression by the C. elegans Argonaute CSR-1

(2013) Christopher J. Wedeles et al.   DEVELOPMENTAL CELL

Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content

(2013) Tod Fullston et al.   FASEB JOURNAL

Multiple roles for Piwi in silencing Drosophila transposons

(2013) N. V. Rozhkov et al.   GENES & DEVELOPMENT

Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state

(2013) A. Le Thomas et al.   GENES & DEVELOPMENT

Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation

(2013) A. B. Rodgers et al.   JOURNAL OF NEUROSCIENCE

Parental olfactory experience influences behavior and neural structure in subsequent generations

(2013) Brian G Dias et al.   NATURE NEUROSCIENCE

PIWI-interacting RNAs: from generation to transgenerational epigenetics

(2013) Maartje J. Luteijn et al.   NATURE REVIEWS GENETICS

tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma

(2013) Roy L. Maute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetics: Core misconcept

(2013) M. Ptashne   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA–Mediated Epigenetic Heredity Requires the Cytosine Methyltransferase Dnmt2

(2013) Jafar Kiani et al.   PLoS Genetics

C. elegans piRNAs Mediate the Genome-wide Surveillance of Germline Transcripts

(2012) Heng-Chi Lee et al.   CELL

Daddy Issues: Paternal Effects on Phenotype

(2012) Oliver J. Rando   CELL

Transcriptional Silencing of Transposons by Piwi and Maelstrom and Its Impact on Chromatin State and Gene Expression

(2012) Grzegorz Sienski et al.   CELL

piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans

(2012) Alyson Ashe et al.   CELL

piRNAs Initiate an Epigenetic Memory of Nonself RNA in the C. elegans Germline

(2012) Masaki Shirayama et al.   CELL

Protection from Feed-Forward Amplification in an Amplified RNAi Mechanism

(2012) Julia Pak et al.   CELL

A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm

(2012) Hongying Peng et al.   CELL RESEARCH

Extremely stable Piwi-induced gene silencing inCaenorhabditis elegans

(2012) Maartje J Luteijn et al.   EMBO JOURNAL

Paternal dietary restriction affects progeny fat content in Caenorhabditis elegans

(2012) Claudia Miersch et al.   IUBMB LIFE

A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality

(2012) Bethany A. Buckley et al.   NATURE

Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint

(2012) Sam Guoping Gu et al.   NATURE GENETICS

Transgenerational Effects of Parental Larval Diet on Offspring Development Time, Adult Body Size and Pathogen Resistance in Drosophila melanogaster

(2012) Terhi M. Valtonen et al.   PLoS One

Function, Targets, and Evolution of Caenorhabditis elegans piRNAs

(2012) M. P. Bagijn et al.   SCIENCE

Paternal Transmission of Stress-Induced Pathologies

(2011) David M. Dietz et al.   BIOLOGICAL PSYCHIATRY

Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change

(2011) Ki-Hyeon Seong et al.   CELL

Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegans

(2011) Oded Rechavi et al.   CELL

Genes for embryo development are packaged in blocks of multivalent chromatin in zebrafish sperm

(2011) S.-F. Wu et al.   GENOME RESEARCH

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

(2011) Eric L. Greer et al.   NATURE

Variation in genome-wide mutation rates within and between human families

(2011) Donald F Conrad et al.   NATURE GENETICS

Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans

(2011) N. O. Burton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells

(2011) Y. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Transgenerational Inheritance of Glucose Intolerance in a Mouse Model of Neonatal Overnutrition

(2010) Thais Pentinat et al.   ENDOCRINOLOGY

Distinct Phases of siRNA Synthesis in an Endogenous RNAi Pathway in C. elegans Soma

(2010) Jonathan I. Gent et al.   MOLECULAR CELL

Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription

(2010) Shouhong Guang et al.   NATURE

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

Human tRNA-derived small RNAs in the global regulation of RNA silencing

(2010) D. Haussecker et al.   RNA

Epigenetic Reprogramming in Plant and Animal Development

(2010) Suhua Feng et al.   SCIENCE

Trans-generational epigenetic regulation of C. elegans primordial germ cells

(2010) Hirofumi Furuhashi et al.   Epigenetics & Chromatin

The Histone H3K36 Methyltransferase MES-4 Acts Epigenetically to Transmit the Memory of Germline Gene Expression to Progeny

(2010) Andreas Rechtsteiner et al.   PLoS Genetics

Effects of parental larval diet on egg size and offspring traits in Drosophila

(2009) R. K. Vijendravarma et al.   Biology Letters

The Argonaute CSR-1 and Its 22G-RNA Cofactors Are Required for Holocentric Chromosome Segregation

(2009) Julie M. Claycomb et al.   CELL

A C. elegans LSD1 Demethylase Contributes to Germline Immortality by Reprogramming Epigenetic Memory

(2009) David J. Katz et al.   CELL

Distinctive chromatin in human sperm packages genes for embryo development

(2009) Saher Sue Hammoud et al.   NATURE

Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice

(2008) J. C. Jimenez-Chillaron et al.   DIABETES

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes

(2008) S. Kuramochi-Miyagawa et al.   GENES & DEVELOPMENT

Transmission Dynamics of Heritable Silencing Induced by Double-Stranded RNA in Caenorhabditis elegans

(2008) Rosa M. Alcazar et al.   GENETICS

Genome Integrity Is Regulated by the Caenorhabditis elegans Rad51D Homolog rfs-1

(2008) J. L. Yanowitz   GENETICS

A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice

(2008) Alexei A. Aravin et al.   MOLECULAR CELL

PRG-1 and 21U-RNAs Interact to Form the piRNA Complex Required for Fertility in C. elegans

(2008) Pedro J. Batista et al.   MOLECULAR CELL

An Argonaute Transports siRNAs from the Cytoplasm to the Nucleus

(2008) S. Guang et al.   SCIENCE

What is an epigenetic transgenerational phenotype?

(2007) Michael K. Skinner   REPRODUCTIVE TOXICOLOGY