Tadalafil ameliorates bladder overactivity by restoring insulin-activated detrusor relaxation via the bladder mucosal IRS/PI3K/AKT/eNOS pathway in fructose-fed rats

Tadalafil for the treatment of benign prostatic hyperplasia

(2019) Fabiola Zakia Mónica et al.   EXPERT OPINION ON PHARMACOTHERAPY

A Comprehensive Review of Overactive Bladder Pathophysiology: On the Way to Tailored Treatment

(2019) Benoit Peyronnet et al.   EUROPEAN UROLOGY

Dietary Fructose and the Metabolic Syndrome

(2019) Taskinen et al.   Nutrients

Inhibition of Multidrug Resistance Proteins by MK 571 Enhances Bladder, Prostate, and Urethra Relaxation through cAMP or cGMP Accumulation

(2018) Gabriela Maria Bertollotto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The IRS/PI3K/Akt signaling pathway mediates olanzapine-induced hepatic insulin resistance in male rats

(2018) Liying Ren et al.   LIFE SCIENCES

Association between metabolic syndrome and overactive bladder: a case–control study

(2017) Zana Saratlija Novakovic et al.   Scandinavian Journal of Urology

Animal models of metabolic syndrome: a review

(2016) Sok Kuan Wong et al.   Nutrition & Metabolism

Saxagliptin and Tadalafil Differentially Alter Cyclic Guanosine Monophosphate (cGMP) Signaling and Left Ventricular Function in Aortic‐Banded Mini‐Swine

(2016) Jessica A. Hiemstra et al.   Journal of the American Heart Association

Maternal Fructose Exposure Programs Metabolic Syndrome-Associated Bladder Overactivity in Young Adult Offspring

(2016) Wei-Chia Lee et al.   Scientific Reports

Therapeutic Use of Metformin in Prediabetes and Diabetes Prevention

(2015) Ulrike Hostalek et al.   DRUGS

Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling

(2014) Saisudha Koka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Prevalence of Metabolic Syndrome and Obesity-Associated Hypertension in the Racial Ethnic Minorities of the United States

(2014) Bonita Falkner et al.   CURRENT HYPERTENSION REPORTS

Hyposensitivity of C-fiber Afferents at the Distal Extremities as an Indicator of Early Stages Diabetic Bladder Dysfunction in Type 2 Diabetic Women

(2014) Wei-Chia Lee et al.   PLoS One

Insulin relaxes bladder via PI3K/AKT/eNOS pathway activation in mucosa: unfolded protein response-dependent insulin resistance as a cause of obesity-associated overactive bladder

(2013) Luiz O. Leiria et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sildenafil Promotes eNOS Activation and Inhibits NADPH Oxidase in the Transgenic Sickle Cell Mouse Penis

(2013) Biljana Musicki et al.   Journal of Sexual Medicine

Urothelial Signaling

(2013) Lori Birder et al.   PHYSIOLOGICAL REVIEWS

Molecular Fingerprint of High Fat Diet Induced Urinary Bladder Metabolic Dysfunction in a Rat Model

(2013) Andreas Oberbach et al.   PLoS One

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Alterations in peripheral purinergic and muscarinic signaling of rat bladder after long-term fructose-induced metabolic syndrome

(2012) Shiu-Dong Chung et al.   EUROPEAN JOURNAL OF NUTRITION

Sensory Dysfunction of Bladder Mucosa and Bladder Oversensitivity in a Rat Model of Metabolic Syndrome

(2012) Wei-Chia Lee et al.   PLoS One

Characterization of Phosphodiesterase Type 5 Expression and Functional Activity in the Human Male Lower Urinary Tract

(2009) Benedetta Fibbi et al.   Journal of Sexual Medicine

Structure – Activity Relationships of PDE5 Inhibitors (Supporting Material)

(2008) D. Eros et al.   CURRENT MEDICINAL CHEMISTRY

Bladder Dysfunction in Rats With Metabolic Syndrome Induced by Long-Term Fructose Feeding

(2008) Wei-Chia Lee et al.   JOURNAL OF UROLOGY