Urothelial Signaling

Electrical Stimulation of the Urethra Evokes Bladder Contractions in a Woman With Spinal Cord Injury

(2016) Michael J. Kennelly et al.   JOURNAL OF SPINAL CORD MEDICINE

Transient receptor potential vanilloid 1 mediates nerve growth factor-induced bladder hyperactivity and noxious input

(2012) Barbara Frias et al.   BJU INTERNATIONAL

Differential expression and function of nicotinic acetylcholine receptors in the urinary bladder epithelium of the rat

(2012) Jonathan M. Beckel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Identification of PDGFRα Positive Populations of Interstitial Cells in Human and Guinea Pig Bladders

(2012) Kevin P. Monaghan et al.   JOURNAL OF UROLOGY

Urethral flow-responsive afferents in the cat sacral dorsal root ganglia

(2012) Andre’ E. Snellings et al.   NEUROSCIENCE LETTERS

Second Multicenter, Randomized, Double-blind, Parallel-group Evaluation of Effectiveness and Safety of Intravesical Sodium Chondroitin Sulfate Compared With Inactive Vehicle Control in Subjects With Interstitial Cystitis/Bladder Pain Syndrome

(2012) J. Curtis Nickel et al.   UROLOGY

Unique properties of muscularis mucosae smooth muscle in guinea pig urinary bladder

(2011) Thomas J. Heppner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Differential Response of the Urothelial V-ATPase Activity to the Lipid Environment

(2011) E. J. Grasso et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Cyclosporine A Induces Nerve Growth Factor Expression Via Activation of MAPK p38 and NFAT5

(2011) Joon H Lee et al.   CORNEA

Targeting the visceral purinergic system for pain control

(2011) G Burnstock   CURRENT OPINION IN PHARMACOLOGY

Nitro-oleic acid targets transient receptor potential (TRP) channels in capsaicin sensitive afferent nerves of rat urinary bladder

(2011) D.E. Artim et al.   EXPERIMENTAL NEUROLOGY

Effect of hyaluronic acid on urine nerve growth factor in cyclophosphamide-induced cystitis

(2011) Dong-Ru Ho et al.   INTERNATIONAL JOURNAL OF UROLOGY

Characterization of upper lamina propria interstitial cells in bladders from patients with neurogenic detrusor overactivity and bladder pain syndrome

(2011) Thomas Gevaert et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Platelet-derived growth factor receptor-α cells in mouse urinary bladder: a new class of interstitial cells

(2011) Byoung H. Koh et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target

(2011) Jiarong Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Acid-Sensing Channels in Human Bladder: Expression, Function and Alterations During Bladder Pain Syndrome

(2011) Verónica Sánchez-Freire et al.   JOURNAL OF UROLOGY

Functional Properties of Suburothelial Microvessels in the Rat Bladder

(2011) Hikaru Hashitani et al.   JOURNAL OF UROLOGY

Proof of Concept Trial of Tanezumab for the Treatment of Symptoms Associated With Interstitial Cystitis

(2011) R.J. Evans et al.   JOURNAL OF UROLOGY

The Mechanoreceptor TRPV4 is Localized in Adherence Junctions of the Human Bladder Urothelium: A Morphological Study

(2011) Dick A.W. Janssen et al.   JOURNAL OF UROLOGY

Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder

(2011) Kunyoo Shin et al.   NATURE

Increased transient receptor potential vanilloid type 1 (TRPV1) signaling in idiopathic overactive bladder urothelial cells

(2011) Mingkai Li et al.   NEUROUROLOGY AND URODYNAMICS

Estrogens and the lower urinary tract

(2011) Dudley Robinson et al.   NEUROUROLOGY AND URODYNAMICS

Researching bladder afferents-determining the effects of β3-adrenergic receptor agonists and botulinum toxin type-A

(2011) Anthony Kanai et al.   NEUROUROLOGY AND URODYNAMICS

Effects of TRPV4 cation channel activation on the primary bladder afferent activities of the rat

(2011) Naoki Aizawa et al.   NEUROUROLOGY AND URODYNAMICS

Muscarinic receptors stimulate cell proliferation in the human urothelium-derived cell line UROtsa

(2011) Nicola Arrighi et al.   PHARMACOLOGICAL RESEARCH

Expression and Distribution of Ectonucleotidases in Mouse Urinary Bladder

(2011) Weiqun Yu et al.   PLoS One

ATP Enhances Spontaneous Calcium Activity in Cultured Suburothelial Myofibroblasts of the Human Bladder

(2011) Sheng Cheng et al.   PLoS One

In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization

(2011) Anthony P. Ford   Purinergic Signalling

Spinal Cord Injury and Bladder Dysfunction: New Ideas about an Old Problem

(2011) Célia Duarte Cruz et al.   TheScientificWorldJOURNAL

Urothelial/Lamina Propria Spontaneous Activity and the Role of M3 Muscarinic Receptors in Mediating Rate Responses to Stretch and Carbachol

(2011) Christian Moro et al.   UROLOGY

The Effects of Acute and Chronic Psychological Stress on Bladder Function in a Rodent Model

(2011) Ariana L. Smith et al.   UROLOGY

Interactions Between Cholinergic and Prostaglandin Signaling Elements in the Urothelium: Role for Muscarinic Type 2 Receptors

(2011) C.J. Nile et al.   UROLOGY

Examining the Role of Mechanosensitive Ion Channels in Pressure Mechanotransduction in Rat Bladder Urothelial Cells

(2010) Shawn M. Olsen et al.   ANNALS OF BIOMEDICAL ENGINEERING

The role of the transient receptor potential (TRP) superfamily of cation-selective channels in the management of the overactive bladder

(2010) Karl-Erik Andersson et al.   BJU INTERNATIONAL

Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats

(2010) Timothy K. Y. Kaan et al.   BRAIN

Effects of stimulation of muscarinic receptors on bladder afferent nerves in the in vitro bladder–pelvic afferent nerve preparation of the rat

(2010) Yongbei Yu et al.   BRAIN RESEARCH

AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist

(2010) Joel R Gever et al.   BRITISH JOURNAL OF PHARMACOLOGY

β−Adrenergic receptor subtype expression in myocyte and non-myocyte cells in human female bladder

(2010) Brian J. Limberg et al.   CELL AND TISSUE RESEARCH

Nerve growth factor enhances Clara cell proliferation after lung injury

(2010) S. S. Sonar et al.   EUROPEAN RESPIRATORY JOURNAL

Antimuscarinic Mechanisms and the Overactive Detrusor: An Update

(2010) Karl-Erik Andersson   EUROPEAN UROLOGY

Effects of Nitric Oxide on the Primary Bladder Afferent Activities of the Rat With and Without Intravesical Acrolein Treatment

(2010) Naoki Aizawa et al.   EUROPEAN UROLOGY

Host‐Pathogen Interactions Mediating Pain of Urinary Tract Infection

(2010) Charles N. Rudick et al.   JOURNAL OF INFECTIOUS DISEASES

Endogenous Purinergic Control of Bladder Activity via Presynaptic P2X3 and P2X2/3 Receptors in the Spinal Cord

(2010) T. K. Y. Kaan et al.   JOURNAL OF NEUROSCIENCE

Prostaglandin Receptor EP1 and EP2 Site in Guinea Pig Bladder Urothelium and Lamina Propria

(2010) Mohammad Sajjad Rahnama'i et al.   JOURNAL OF UROLOGY

A Watershed Year for Interstitial Cystitis

(2010) C.A. Tony Buffington   JOURNAL OF UROLOGY

1669 NERVE GROWTH FACTOR LEVELS IN URINE CORRELATE WITH EXPRESSION IN UROTHELIUM BUT NOT SUBUROTHELIUM IN THE BLADDER TISSUES OF OVERACTIVE BLADDER SYNDROME

(2010) Hsin-Tzu Liu et al.   JOURNAL OF UROLOGY

Bladder Afferent Signaling: Recent Findings

(2010) Anthony Kanai et al.   JOURNAL OF UROLOGY

Morphological Expression of KIT Positive Interstitial Cells of Cajal in Human Bladder

(2010) Louise Johnston et al.   JOURNAL OF UROLOGY

The β3-adrenoceptor mediates the inhibitory effects of β-adrenoceptor agonists via the urothelium in pig bladder dome

(2010) Koichi Masunaga et al.   NEUROUROLOGY AND URODYNAMICS

Urothelial beta-3 adrenergic receptors in the rat bladder

(2010) F. Aura Kullmann et al.   NEUROUROLOGY AND URODYNAMICS

Differential Regulation of Growth-Promoting Signalling Pathways by E-Cadherin

(2010) Nikolaos T. Georgopoulos et al.   PLoS One

Urologic Chronic Pelvic Pain Syndrome

(2010) Viviana Martinez-Bianchi et al.   PRIMARY CARE

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

(2010) W. Everaerts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Multicenter, Randomized, Double-blind, Parallel Group Pilot Evaluation of the Efficacy and Safety of Intravesical Sodium Chondroitin Sulfate Versus Vehicle Control in Patients With Interstitial Cystitis/Painful Bladder Syndrome

(2010) J. Curtis Nickel et al.   UROLOGY

Removal of urothelium affects bladder contractility and release of ATP but not release of NO in rat urinary bladder

(2010) Alvaro Munoz et al.   BMC Urology

Social stress-induced bladder dysfunction: potential role of corticotropin-releasing factor

(2009) Susan K. Wood et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function

(2009) Birthe Schnegelsberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Apical Plasma Membrane Traffic in Superficial Cells of Bladder Urothelium

(2009) Mateja Erdani Kreft et al.   Annals of the New York Academy of Sciences

Identification of the vesicular nucleotide transporter (VNUT) in taste cells

(2009) Ken Iwatsuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

M3muscarinic receptor expression on suburothelial interstitial cells

(2009) Simone Grol et al.   BJU INTERNATIONAL

Instillation of liposomes vs dimethyl sulphoxide or pentosan polysulphate for reducing bladder hyperactivity

(2009) Pradeep Tyagi et al.   BJU INTERNATIONAL

Stretch independent regulation of prostaglandin E2production within the isolated guinea-pig lamina propria

(2009) Christopher J. Nile et al.   BJU INTERNATIONAL

Endocytotic activity of bladder superficial urothelial cells is inversely related to their differentiation stage

(2009) Mateja Erdani Kreft et al.   DIFFERENTIATION

Are There Myofibroblasts in Normal Bladder?

(2009) Brian Eyden   EUROPEAN UROLOGY

A Refocus on the Bladder as the Originator of Storage Lower Urinary Tract Symptoms: A Systematic Review of the Latest Literature

(2009) Alexander Roosen et al.   EUROPEAN UROLOGY

In Vitro Release of Adenosine Triphosphate from the Urothelium of Human Bladders with Detrusor Overactivity, Both Neurogenic and Idiopathic

(2009) Vivek Kumar et al.   EUROPEAN UROLOGY

Expression of P2X3 purinoceptors in suburothelial myofibroblasts of the normal human urinary bladder

(2009) Fei Liu et al.   INTERNATIONAL JOURNAL OF UROLOGY

Effects of  3-Adrenergic Receptor Activation on Rat Urinary Bladder Hyperactivity Induced by Ovariectomy

(2009) F. A. Kullmann et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Functional Transient Receptor Potential Vanilloid 1 is Expressed in Human Urothelial Cells

(2009) Ana Charrua et al.   JOURNAL OF UROLOGY

Increased Startle Responses in Interstitial Cystitis: Evidence for Central Hyperresponsiveness to Visceral Related Threat

(2009) Christian Twiss et al.   JOURNAL OF UROLOGY

Mucosal Muscarinic Receptors Enhance Bladder Activity in Cats With Feline Interstitial Cystitis

(2009) Y. Ikeda et al.   JOURNAL OF UROLOGY

Receptor Isoforms That Mediate Estrogen and Progestagen Action in the Female Lower Urinary Tract

(2009) Douglas G. Tincello et al.   JOURNAL OF UROLOGY

The bladder extracellular matrix. Part I: architecture, development and disease

(2009) Karen J. Aitken et al.   Nature Reviews Urology

Effects of CL316,243, a β3-adrenoceptor agonist, and intravesical prostaglandin E2 on the primary bladder afferent activity of the rat

(2009) Naoki Aizawa et al.   NEUROUROLOGY AND URODYNAMICS

Bladder urothelial cells from patients with interstitial cystitis have an increased sensitivity to carbachol

(2009) Gopal N. Gupta et al.   NEUROUROLOGY AND URODYNAMICS

Interstitial cells in the urinary bladder—localization and function

(2009) Karen D. McCloskey   NEUROUROLOGY AND URODYNAMICS

Beyond neurons: Involvement of urothelial and glial cells in bladder function

(2009) Lori A. Birder et al.   NEUROUROLOGY AND URODYNAMICS

Detrusor myocyte activity and afferent signaling

(2009) Karl-Erik Andersson   NEUROUROLOGY AND URODYNAMICS

Investigations into the presence of functional ß1, ß2 and ß3-adrenoceptors in urothelium and detrusor of human bladder

(2009) Pradeep Tyagi et al.   International Braz J Urol

Bacteria-Induced Uroplakin Signaling Mediates Bladder Response to Infection

(2009) Praveen Thumbikat et al.   PLoS Pathogens

Diagnostic Utility of Antibody to Smoothelin in the Distinction of Muscularis Propria From Muscularis Mucosae of the Urinary Bladder

(2008) Gladell P. Paner et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

The involvement of urothelial α1A adrenergic receptor in controlling the micturition reflex

(2008) Haruko Yanase et al.   BIOMEDICAL RESEARCH-TOKYO

Botulinum toxin type A inhibits sensory neuropeptide release in rat bladder models of acute injury and chronic inflammation

(2008) Alvaro Lucioni et al.   BJU INTERNATIONAL

Activity of different phospholipids in attenuating hyperactivity in bladder irritation

(2008) Pradeep Tyagi et al.   BJU INTERNATIONAL

Protective effect of aminoguanidine against oxidative stress and bladder injury in cyclophosphamide-induced hemorrhagic cystitis in rat

(2008) Premila Abraham et al.   CELL BIOCHEMISTRY AND FUNCTION

Roles of estrogen receptor   and   in modulating urothelial cell proliferation

(2008) J. Teng et al.   ENDOCRINE-RELATED CANCER

The G Protein-Coupled Receptor GPR30 Inhibits Human Urothelial Cell Proliferation

(2008) Jian Teng et al.   ENDOCRINOLOGY

Histological Changes in the Urothelium and Suburothelium of Human Overactive Bladder following Intradetrusor Injections of Botulinum Neurotoxin Type A for the Treatment of Neurogenic or Idiopathic Detrusor Overactivity

(2008) Apostolos Apostolidis et al.   EUROPEAN UROLOGY

Urinary Nerve Growth Factor Levels are Elevated in Patients with Detrusor Overactivity and Decreased in Responders to Detrusor Botulinum Toxin-A Injection

(2008) Hsin-Tzu Liu et al.   EUROPEAN UROLOGY

Roles of mechanosensitive ion channels in bladder sensory transduction and overactive bladder

(2008) Isao Araki et al.   INTERNATIONAL JOURNAL OF UROLOGY

Differential Localizations of the Transient Receptor Potential Channels TRPV4 and TRPV1 in the Mouse Urinary Bladder

(2008) Takahiro Yamada et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Urine Markers Do Not Predict Biopsy Findings or Presence of Bladder Ulcers in Interstitial Cystitis/Painful Bladder Syndrome

(2008) Deborah R. Erickson et al.   JOURNAL OF UROLOGY

GRC-6211, a New Oral Specific TRPV1 Antagonist, Decreases Bladder Overactivity and Noxious Bladder Input in Cystitis Animal Models

(2008) Ana Charrua et al.   JOURNAL OF UROLOGY

Expression and functional role of β-adrenoceptors in the human urinary bladder urothelium

(2008) Atsushi Otsuka et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice

(2008) Zun-Yi Wang et al.   PAIN

Chronic pain may change the structure of the brain

(2008) Arne May   PAIN

The topical application of nerve growth factor as a pharmacological tool for human corneal and skin ulcers

(2008) L ALOE et al.   PHARMACOLOGICAL RESEARCH

Urothelial effects of oral agents for overactive bladder

(2008) Karl-Erik Andersson et al.   Current Urology Reports

Distribution and Function of the Hydrogen Sulfide–Sensitive TRPA1 Ion Channel in Rat Urinary Bladder

(2007) Tomi Streng et al.   EUROPEAN UROLOGY

Botulinum toxin type A normalizes alterations in urothelial ATP and NO release induced by chronic spinal cord injury

(2007) Christopher P. Smith et al.   NEUROCHEMISTRY INTERNATIONAL

On the origin of bladder sensing: Tr(i)ps in urology

(2007) Wouter Everaerts et al.   NEUROUROLOGY AND URODYNAMICS

Detection of muscarinic receptor subtypes in human urinary bladder mucosa: Age and gender-dependent modifications

(2007) Nicola Arrighi et al.   NEUROUROLOGY AND URODYNAMICS