IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques

SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity

(2021) Nicolas Huot et al.   Nature Communications

Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

(2020) Julia Bergild McBrien et al.   NATURE

HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells

(2020) Yetao Wang et al.   NATURE IMMUNOLOGY

African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity

(2020) Kevin D. Raehtz et al.   PLoS Pathogens

Virologic and immunologic features of SIV control post ART interruption in rhesus macaques

(2020) Zachary Strongin et al.   JOURNAL OF VIROLOGY

CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

(2020) Justin Harper et al.   NATURE MEDICINE

Non-human Primate Determinants of Natural Killer Cells in Tissues at Steady-State and During Simian Immunodeficiency Virus Infection

(2020) Nicolas Huot et al.   Frontiers in Immunology

ART reduces T cell activation and immune exhaustion markers in HIV controllers

(2019) Jonathan Z Li et al.   CLINICAL INFECTIOUS DISEASES

NK Response Correlates with HIV Decrease in Pegylated IFN-α2a–Treated Antiretroviral Therapy–Suppressed Subjects

(2019) Emmanouil Papasavvas et al.   JOURNAL OF IMMUNOLOGY

Short-Term Pegylated Interferon α2a Treatment Does Not Significantly Reduce the Viral Reservoir of Simian Immunodeficiency Virus-Infected, Antiretroviral Therapy-Treated Rhesus Macaques

(2018) David Palesch et al.   JOURNAL OF VIROLOGY

ElevatedHLA-Aexpression impairs HIV control through inhibition of NKG2A-expressing cells

(2018) Veron Ramsuran et al.   SCIENCE

Lymph Node Cellular and Viral Dynamics in Natural Hosts and Impact for HIV Cure Strategies

(2018) Nicolas Huot et al.   Frontiers in Immunology

Interferon Alpha Enhances NK Cell Function and the Suppressive Capacity of HIV-Specific CD8+ T Cells

(2018) Abena K. R. Kwaa et al.   JOURNAL OF VIROLOGY

CD8+ lymphocyte control of SIV infection during antiretroviral therapy

(2018) Youfang Cao et al.   PLoS Pathogens

CTLA-4 + PD-1 − Memory CD4 + T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques

(2017) Colleen S. McGary et al.   IMMUNITY

Addendum: Immune clearance of highly pathogenic SIV infection

(2017) Scott G. Hansen et al.   NATURE

Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys

(2017) Nicolas Huot et al.   NATURE MEDICINE

IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours

(2017) Hyungseok Seo et al.   Nature Communications

HIV-Specific CD8 + T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue

(2017) Morgan A. Reuter et al.   Cell Reports

Short Communication: Comparative Evaluation of Coformulated Injectable Combination Antiretroviral Therapy Regimens in Simian Immunodeficiency Virus-Infected Rhesus Macaques

(2016) Gregory Q. Del Prete et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

CD8 + Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy

(2016) Emily K. Cartwright et al.   IMMUNITY

Envelope residue 375 substitutions in simian–human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques

(2016) Hui Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

(2015) Luca Micci et al.   JOURNAL OF CLINICAL INVESTIGATION

Antigen-specific NK cell memory in rhesus macaques

(2015) R Keith Reeves et al.   NATURE IMMUNOLOGY

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

(2015) Yoshinori Fukazawa et al.   NATURE MEDICINE

Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1

(2015) Daniel I. S. Rosenbloom et al.   Open Forum Infectious Diseases

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

A new rhesus macaque assembly and annotation for next-generation sequencing analyses

(2014) Aleksey V Zimin et al.   Biology Direct

Increased IL-15 Production Is Associated with Higher Susceptibility of Memory CD4 T Cells to Simian Immunodeficiency Virus during Acute Infection

(2014) M. D. Eberly et al.   JOURNAL OF IMMUNOLOGY

Reconstitution of Intestinal CD4 and Th17 T Cells in Antiretroviral Therapy Suppressed HIV-Infected Subjects: Implication for Residual Immune Activation from the Results of a Clinical Trial

(2014) Gabriella d'Ettorre et al.   PLoS One

Innate Immune Responses and Rapid Control of Inflammation in African Green Monkeys Treated or Not with Interferon-Alpha during Primary SIVagm Infection

(2014) Béatrice Jacquelin et al.   PLoS Pathogens

Maintenance of Intestinal Th17 Cells and Reduced Microbial Translocation in SIV-infected Rhesus Macaques Treated with Interleukin (IL)-21

(2013) Suresh Pallikkuth et al.   PLoS Pathogens

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation

(2012) T. H. Vanderford et al.   BLOOD

Pegylated Interferon Alfa-2a Monotherapy Results in Suppression of HIV Type 1 Replication and Decreased Cell-Associated HIV DNA Integration

(2012) Livio Azzoni et al.   JOURNAL OF INFECTIOUS DISEASES

SPICE: Exploration and analysis of post-cytometric complex multivariate datasets

(2011) Mario Roederer et al.   CYTOMETRY PART A

IFN-α primes T- and NK-cells for IL-15-mediated signaling and cytotoxicity

(2011) Mikkel L. Hansen et al.   MOLECULAR IMMUNOLOGY

Alpha interferon administration during structured interruptions of combination antiretroviral therapy in patients with chronic HIV-1 infection: INTERVAC ANRS 105 trial

(2010) François Boué et al.   AIDS

Critical role for the chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and viruses

(2010) Silke Paust et al.   NATURE IMMUNOLOGY

Soluble PD-1 rescues the proliferative response of simian immunodeficiency virus-specific CD4 and CD8 T cells during chronic infection

(2008) Nattawat Onlamoon et al.   IMMUNOLOGY