Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis

Surf4 regulates expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) but is not required for PCSK9 secretion in cultured human hepatocytes

(2019) Yishi Shen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

PCSK9

(2018) Michael D. Shapiro et al.   CIRCULATION RESEARCH

Associations Between Soluble LDLR and Lipoproteins in a Caucasian Cohort and The Effect of PCSK9 Loss-of-Function

(2018) J Mayne et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Plasma inducible degrader of the LDLR, soluble low-density lipoprotein receptor, and proprotein convertase subtilisin/kexin type 9 levels as potential biomarkers of familial hypercholesterolemia in children

(2018) Josefa Girona et al.   Journal of Clinical Lipidology

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation

(2018) Pirita Pekkonen et al.   eLife

Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs

(2018) Tamar Y. Feinberg et al.   DEVELOPMENTAL CELL

MMP14 predicts a poor prognosis in patients with colorectal cancer

(2018) Guangfei Cui et al.   HUMAN PATHOLOGY

PCSK9 inhibitors: clinical evidence and implementation

(2018) Marc S. Sabatine   Nature Reviews Cardiology

Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype

(2017) John S. Chorba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion

(2017) M Swayampakula et al.   ONCOGENE

New developments in proprotein convertase subtilisin–kexin 9ʼs biology and clinical implications

(2016) Nabil G. Seidah   CURRENT OPINION IN LIPIDOLOGY

Upregulation of cyclin-dependent kinase 7 and matrix metalloproteinase-14 expression contribute to metastatic properties of gastric cancer

(2016) Ghodratolah Naseh et al.   IUBMB LIFE

Functional Differences of Very-Low-Density Lipoprotein Receptor Splice Variants in Regulating Wnt Signaling

(2016) Qian Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries

(2016) Dong Hyun Nam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of an Amino Acid Residue Critical for Plasma Membrane Localization of ATP-Binding Cassette Transporter G1—Brief ReportSignificance

(2015) Hong-mei Gu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

(2015) Joseph L. Goldstein et al.   CELL

MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells

(2015) Xiang Wang et al.   FEBS LETTERS

Membrane-type matrix metalloproteinases: Their functions and regulations

(2015) Yoshifumi Itoh   MATRIX BIOLOGY

Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux

(2014) Hong-mei Gu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

PCSK9

(2014) Nabil G. Seidah et al.   CIRCULATION RESEARCH

The novel variant p.Ser465Leu in the PCSK9 gene does not account for the decreased LDLR activity in members of a FH family

(2014) Anna Ruotolo et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

PCSK9 and LDLR degradation

(2014) Thomas A. Lagace   CURRENT OPINION IN LIPIDOLOGY

Association Between Serum Soluble Low-Density Lipoprotein Receptor Levels and Metabolic Factors in Healthy Japanese Individuals

(2014) Hisashi Shimohiro et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Mutation G805R in the transmembrane domain of the LDL receptor gene causes familial hypercholesterolemia by inducing ectodomain cleavage of the LDL receptor in the endoplasmic reticulum

(2014) Thea Bismo Strøm et al.   FEBS Open Bio

Monocyte/Macrophage MMP-14 Modulates Cell Infiltration and T-Cell Attraction in Contact Dermatitis But Not in Murine Wound Healing

(2013) Anke Klose et al.   AMERICAN JOURNAL OF PATHOLOGY

Characterization of the Role of a Highly Conserved Sequence in ATP Binding Cassette Transporter G (ABCG) Family in ABCG1 Stability, Oligomerization, and Trafficking

(2013) Faqi Wang et al.   BIOCHEMISTRY

Characterization of palmitoylation of ATP binding cassette transporter G1: Effect on protein trafficking and function

(2013) Hong-mei Gu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Characterization of the role of EGF-A of low density lipoprotein receptor in PCSK9 binding

(2013) Hong-mei Gu et al.   JOURNAL OF LIPID RESEARCH

Decreased APOE-containing HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9

(2013) Seungbum Choi et al.   Lipids in Health and Disease

Characterization of lipid and lipoprotein metabolism in primary human hepatocytes

(2012) Ji Ling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type 9 Reduces Atherosclerosis in Mice

(2012) Maxime Denis et al.   CIRCULATION

Loss of epidermal MMP-14 expression interferes with angiogenesis but not with re-epithelialization

(2012) Paola Zigrino et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Identification of an amino acid residue in ATP-binding cassette transport G1 critical for mediating cholesterol efflux

(2011) Xia Gao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development

(2011) Guoxiang Jin et al.   EMBO JOURNAL

Loss of TGH/Ces3 in Mice Decreases Blood Lipids, Improves Glucose Tolerance, and Increases Energy Expenditure

(2010) Enhui Wei et al.   Cell Metabolism

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE

Low Tissue Inhibitor of Metalloproteinases 3 and High Matrix Metalloproteinase 14 Levels Defines a Subpopulation of Highly Invasive Foam-Cell Macrophages

(2008) Jason L. Johnson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration

(2008) Ahmed Zaid et al.   HEPATOLOGY

MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing

(2008) K. Lehti et al.   JOURNAL OF CELL SCIENCE

Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

(2008) D.-W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA