Mutation G805R in the transmembrane domain of the LDL receptor gene causes familial hypercholesterolemia by inducing ectodomain cleavage of the LDL receptor in the endoplasmic reticulum

PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment

(2013) Kristian Tveten et al.   JOURNAL OF LIPID RESEARCH

Cleaning Up: ER-Associated Degradation to the Rescue

(2012) Jeffrey L. Brodsky   CELL

Ectodomain shedding and ADAMs in development

(2012) S. Weber et al.   DEVELOPMENT

Ensembl 2013

(2012) Paul Flicek et al.   NUCLEIC ACIDS RESEARCH

Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics

(2012) Syed M Moin et al.   eLife

Characterization of a naturally occurring degradation product of the LDL receptor

(2011) Kristian Tveten et al.   MOLECULAR GENETICS AND METABOLISM

Regulated Intramembrane Proteolysis: Signaling Pathways and Biological Functions

(2011) Mark Lal et al.   PHYSIOLOGY

Intramembrane Proteolysis in Regulated Protein Trafficking

(2011) Marius K. Lemberg   TRAFFIC

Arginine in Membranes: The Connection Between Molecular Dynamics Simulations and Translocon-Mediated Insertion Experiments

(2010) Eric V. Schow et al.   JOURNAL OF MEMBRANE BIOLOGY

Changes in Transmembrane Helix Alignment by Arginine Residues Revealed by Solid-State NMR Experiments and Coarse-Grained MD Simulations

(2010) Vitaly V. Vostrikov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY