LDHA induces EMT gene transcription and regulates autophagy to promote the metastasis and tumorigenesis of papillary thyroid carcinoma

Selected Aspects of Chemoresistance Mechanisms in Colorectal Carcinoma—A Focus on Epithelial-to-Mesenchymal Transition, Autophagy, and Apoptosis

(2019) Veronika Skarkova et al.   Cells

Targeting super-enhancer-driven oncogenic transcription by CDK7 inhibition in anaplastic thyroid cancer

(2019) Xinyi Cao et al.   THYROID

Histone Modifications and their Role in Colorectal Cancer (Review)

(2019) Jingchun Qin et al.   PATHOLOGY & ONCOLOGY RESEARCH

Lactate dehydrogenase A regulates autophagy and tamoxifen resistance in breast cancer

(2019) Chandan Kanta Das et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pro-survival autophagy: An emerging candidate of tumor progression through maintaining hallmarks of cancer

(2019) Chandan Kanta Das et al.   SEMINARS IN CANCER BIOLOGY

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Pro-survival autophagy and cancer cell resistance to therapy

(2018) Chandan Kanta Das et al.   CANCER AND METASTASIS REVIEWS

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

LDHA in neuroblastoma is associated with poor outcome and its depletion decreases neuroblastoma growth independent of aerobic glycolysis

(2018) Carmen Dorneburg et al.   CLINICAL CANCER RESEARCH

LDHA upregulation independently predicts poor survival in lung adenocarcinoma, but not in lung squamous cell carcinoma

(2018) Chengyong Yu et al.   Future Oncology

Overall Survival of Papillary Thyroid Carcinoma Patients: A Single-Institution Long-Term Follow-Up of 5897 Patients

(2018) Yasuhiro Ito et al.   WORLD JOURNAL OF SURGERY

LDH-A promotes epithelial–mesenchymal transition by upregulating ZEB2 in intestinal-type gastric cancer

(2018) Yongjie Zhang et al.   OncoTargets and Therapy

Antitumor effects of anlotinib in thyroid cancer

(2018) Xianhui Ruan et al.   ENDOCRINE-RELATED CANCER

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

(2017) Philipp Mews et al.   NATURE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LDH-A promotes malignant progression via activation of epithelial-to-mesenchymal transition and conferring stemness in muscle-invasive bladder cancer

(2016) Fujin Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacological or genetic inhibition of LDHA reverses tumor progression of pediatric osteosarcoma

(2016) Shan Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer

(2016) Lucie Brisson et al.   CANCER CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Targeting autophagy sensitizes BRAF-mutant thyroid cancer to vemurafenib

(2016) Weibin Wang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The changing incidence of thyroid cancer

(2016) Cari M. Kitahara et al.   Nature Reviews Endocrinology

Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma

(2016) Juan Li et al.   NEUROREPORT

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function

(2015) N. V. Rajeshkumar et al.   CANCER RESEARCH

Recent insights into cell death and autophagy

(2015) Brent E. Fitzwalter et al.   FEBS Journal

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Inhibition of LDHA suppresses tumor progression in prostate cancer

(2015) Zhi-Yong Xian et al.   TUMOR BIOLOGY

Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells

(2014) Han Xie et al.   Cell Metabolism

Thyroid cancer mortality and incidence: A global overview

(2014) Carlo La Vecchia et al.   INTERNATIONAL JOURNAL OF CANCER

Lactate dehydrogenase a in cancer: A promising target for diagnosis and therapy

(2013) Ping Miao et al.   IUBMB LIFE

Tp53-induced Glycolysis and Apoptosis Regulator (TIGAR) Protects Glioma Cells from Starvation-induced Cell Death by Up-regulating Respiration and Improving Cellular Redox Homeostasis

(2012) Christina Wanka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Combinatorial Regulation of Neuroblastoma Tumor Progression by N-Myc and Hypoxia Inducible Factor HIF-1 

(2010) G. Qing et al.   CANCER RESEARCH

Selective Autophagy in Cancer Development and Therapy

(2010) Ivan Dikic et al.   CANCER RESEARCH

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins

(2009) Liqing Zhuang et al.   MODERN PATHOLOGY

LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer

(2009) H. Xie et al.   MOLECULAR CANCER THERAPEUTICS

Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth

(2009) Y H Zhao et al.   ONCOGENE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE