Anti-α4 Antibody Treatment Blocks Virus Traffic to the Brain and Gut Early, and Stabilizes CNS Injury Late in Infection

A benefit–risk analysis of natalizumab in the treatment of patients with multiple sclerosis when considering the risk of progressive multifocal leukoencephalopathy

(2013) Anna Walker et al.   CURRENT MEDICAL RESEARCH AND OPINION

Monocyte/macrophages and their role in HIV neuropathogenesis

(2013) Tricia H. Burdo et al.   IMMUNOLOGICAL REVIEWS

How Natalizumab Binds and Antagonizes α4Integrins

(2013) Yamei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antagonizing the  4 1 Integrin, but Not  4 7, Inhibits Leukocytic Infiltration of the Central Nervous System in Rhesus Monkey Experimental Autoimmune Encephalomyelitis

(2013) K. G. Haanstra et al.   JOURNAL OF IMMUNOLOGY

HIV-associated neurocognitive disorder

(2013) David B Clifford et al.   LANCET INFECTIOUS DISEASES

Neurologic Complications and Considerations in HIV-Infected Persons

(2013) Justin McArthur et al.   Current Infectious Disease Reports

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

(2012) Victor Valcour et al.   JOURNAL OF INFECTIOUS DISEASES

Monocyte maturation, HIV susceptibility, and transmigration across the blood brain barrier are critical in HIV neuropathogenesis

(2012) Dionna W. Williams et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment

(2011) Jarek Harezlak et al.   AIDS

Monocyte Mobilization, Activation Markers, and Unique Macrophage Populations in the Brain: Observations from SIV Infected Monkeys Are Informative with Regard to Pathogenic Mechanisms of HIV Infection in Humans

(2011) Kenneth Williams et al.   Journal of Neuroimmune Pharmacology

Brain creatine elevation and N-acetylaspartate reduction indicates neuronal dysfunction in the setting of enhanced glial energy metabolism in a macaque model of NeuroAIDS

(2011) Eva-Maria Ratai et al.   MAGNETIC RESONANCE IN MEDICINE

Minocycline Inhibition of Monocyte Activation Correlates with Neuronal Protection in SIV NeuroAIDS

(2011) Jennifer H. Campbell et al.   PLoS One

Targeting leukocyte migration and adhesion in Crohn’s disease and ulcerative colitis

(2011) Saskia Thomas et al.   INFLAMMOPHARMACOLOGY

Immunophenotyping of lymphocyte, monocyte and dendritic cell subsets in normal rhesus macaques by 12-color flow cytometry: Clarification on DC heterogeneity

(2010) Patrick Autissier et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Clonal Repertoires of Virus-Specific CD8+ T Lymphocytes Are Shared in Mucosal and Systemic Compartments during Chronic Simian Immunodeficiency Virus Infection in Rhesus Monkeys

(2010) P. Sircar et al.   JOURNAL OF IMMUNOLOGY

Disruption of Intestinal CD4+ T Cell Homeostasis Is a Key Marker of Systemic CD4+ T Cell Activation in HIV-Infected Individuals

(2010) S. N. Gordon et al.   JOURNAL OF IMMUNOLOGY

The Large Intestine as a Major Reservoir for Simian Immunodeficiency Virus in Macaques with Long‐Term, Nonprogressing Infection

(2010) Binhua Ling et al.   JOURNAL OF INFECTIOUS DISEASES

Proton Magnetic Resonance Spectroscopy Reveals Neuroprotection by Oral Minocycline in a Nonhuman Primate Model of Accelerated NeuroAIDS

(2010) Eva-Maria Ratai et al.   PLoS One

Antiretroviral Treatment Start-Time during Primary SIVmac Infection in Macaques Exerts a Different Impact on Early Viral Replication and Dissemination

(2010) Pierre Sellier et al.   PLoS One

Increased Monocyte Turnover from Bone Marrow Correlates with Severity of SIV Encephalitis and CD163 Levels in Plasma

(2010) Tricia H. Burdo et al.   PLoS Pathogens

Immunotoxicity profile of natalizumab

(2009) Nancy G. Wehner et al.   Journal of Immunotoxicology

Monitoring α4β7 integrin expression on circulating CD4+ T cells as a surrogate marker for tracking intestinal CD4+ T-cell loss in SIV infection

(2009) X Wang et al.   Mucosal Immunology

α4+β7hiCD4+ memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection

(2009) M Kader et al.   Mucosal Immunology

Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid

(2009) J. Mellergård et al.   Multiple Sclerosis Journal

Increased numbers of circulating hematopoietic stem/progenitor cells are chronically maintained in patients treated with the CD49d blocking antibody natalizumab

(2008) H. Bonig et al.   BLOOD

Persistence of HIV in Gut‐Associated Lymphoid Tissue despite Long‐Term Antiretroviral Therapy

(2008) Tae‐Wook Chun et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

(2008) James Arthos et al.   NATURE IMMUNOLOGY

Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis

(2008) M. Krumbholz et al.   NEUROLOGY

Microbial Translocation Is Associated with Increased Monocyte Activation and Dementia in AIDS Patients

(2008) Petronela Ancuta et al.   PLoS One