Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat

Title
Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat
Authors
Keywords
KRAS, Sotorasib, Sprague Dawley rat, Kidney toxicity, Metabolite, Mercapturic acid pathway
Journal
TOXICOLOGY AND APPLIED PHARMACOLOGY
Volume -, Issue -, Pages 115578
Publisher
Elsevier BV
Online
2021-05-15
DOI
10.1016/j.taap.2021.115578

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