Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice

Exposure to acrylamide decreases noradrenergic axons in rat brain

(2020) Lingyi Zhang et al.   NEUROTOXICOLOGY

Proteomic analysis of hippocampal proteins in acrylamide-exposed Wistar rats

(2019) Daichi Nagashima et al.   ARCHIVES OF TOXICOLOGY

Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both

(2019) Masahiro Akiyama et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The Multifaceted Role of the Ventromedial Prefrontal Cortex in Emotion, Decision Making, Social Cognition, and Psychopathology

(2018) Jaryd Hiser et al.   BIOLOGICAL PSYCHIATRY

Mechanisms underlying neuro-inflammation and neurodevelopmental toxicity in the mouse neocortex following prenatal exposure to ethanol

(2017) Munekazu Komada et al.   Scientific Reports

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Acrylamide content in cigarette mainstream smoke and estimation of exposure to acrylamide from tobacco smoke in Poland

(2016) Hanna Mojska et al.   ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE

Partial contribution of the Keap1–Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells

(2016) Yasuhiro Shinkai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Monitoring Keap1–Nrf2 interactions in single live cells

(2014) Liam Baird et al.   BIOTECHNOLOGY ADVANCES

Detection of changes in the locus coeruleus in patients with mild cognitive impairment and Alzheimer's disease: High-resolution fast spin-echo T1-weighted imaging

(2014) Junko Takahashi et al.   Geriatrics & Gerontology International

The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation

(2014) N. G. Innamorato et al.   JOURNAL OF IMMUNOLOGY

Heterogeneous induction of microglia M2a phenotype by central administration of interleukin-4

(2014) Giovanna Pepe et al.   Journal of Neuroinflammation

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Neuroprotective role of superoxide dismutase 1 in retinal ganglion cells and inner nuclear layer cells against N-methyl-d-aspartate-induced cytotoxicity

(2013) Kenya Yuki et al.   EXPERIMENTAL EYE RESEARCH

Roles Nrf2 Plays in Myeloid Cells and Related Disorders

(2013) Eri Kobayashi et al.   Oxidative Medicine and Cellular Longevity

Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis

(2013) C. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Molecular Mechanism of Acrylamide Neurotoxicity: Lessons Learned from Organic Chemistry

(2012) Richard M. LoPachin et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Inhibition of NF-κB nuclear translocation via HO-1 activation underlies α-tocopheryl succinate toxicity

(2012) Ilaria Bellezza et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

(2012) B. N. Chorley et al.   NUCLEIC ACIDS RESEARCH

Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

(2012) Yosuke Hirotsu et al.   NUCLEIC ACIDS RESEARCH

Exposure to 1-bromopropane induces microglial changes and oxidative stress in the rat cerebellum

(2012) Kaviarasan Subramanian et al.   TOXICOLOGY

Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism

(2011) Agnieszka Jazwa et al.   ANTIOXIDANTS & REDOX SIGNALING

Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors

(2011) Regina Brigelius-Flohé et al.   ANTIOXIDANTS & REDOX SIGNALING

Initial Response and Cellular Protection through the Keap1/Nrf2 System during the Exposure of Primary Mouse Hepatocytes to 1,2-Naphthoquinone

(2011) Takashi Miura et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Isothiocyanates Reduce Mercury Accumulation via an Nrf2-Dependent Mechanism during Exposure of Mice to Methylmercury

(2011) Takashi Toyama et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A new three-dimensional model for emotions and monoamine neurotransmitters

(2011) Hugo Lövheim   MEDICAL HYPOTHESES

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

(2011) E. Mezzaroma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the Nrf2-ARE pathway in acrylamide neurotoxicity

(2011) Lihai Zhang et al.   TOXICOLOGY LETTERS

Features of Microglia and Neuroinflammation Relevant to Environmental Exposure and Neurotoxicity

(2011) Andrew D. Kraft et al.   International Journal of Environmental Research and Public Health

Cytoarchitectonic and chemoarchitectonic characterization of the prefrontal cortical areas in the mouse

(2010) H. J. J. M. Van De Werd et al.   Brain Structure & Function

Different Susceptibility to the Parkinson's Toxin MPTP in Mice Lacking the Redox Master Regulator Nrf2 or Its Target Gene Heme Oxygenase-1

(2010) Nadia G. Innamorato et al.   PLoS One

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

(2010) T. Ogura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Susceptibility of Nrf2-Null Mice to 1-Bromopropane–Induced Hepatotoxicity

(2010) Fang Liu et al.   TOXICOLOGICAL SCIENCES

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

(2009) A.Kenneth MacLeod et al.   CARCINOGENESIS

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice

(2009) Melinda S. Yates et al.   CARCINOGENESIS

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

(2009) Jiyoung Kim et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Acrylamide-Induced Nerve Terminal Damage: Relevance to Neurotoxic and Neurodegenerative Mechanisms

(2008) Richard M. LoPachin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Forward frontal fields: phylogeny and fundamental function

(2008) Steven P. Wise   TRENDS IN NEUROSCIENCES

Catecholamine release and uptake in the mouse prefrontal cortex

(2003) Michelle L. Mundorf et al.   JOURNAL OF NEUROCHEMISTRY