Life-long oligodendrocyte development and plasticity

Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice

(2020) Atsuki Kawamura et al.   HUMAN MOLECULAR GENETICS

The transcription factor NKX2-2 regulates oligodendrocyte differentiation through domain-specific interactions with transcriptional corepressors

(2020) Chengfu Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preservation of a remote fear memory requires new myelin formation

(2020) Simon Pan et al.   NATURE NEUROSCIENCE

Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory

(2020) Fei Wang et al.   NATURE NEUROSCIENCE

Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation

(2020) Roberta Marisca et al.   NATURE NEUROSCIENCE

Diminished ventral oligodendrocyte precursor generation results in the subsequent over-production of dorsal oligodendrocyte precursors of aberrant morphology and function

(2020) Lev Starikov et al.   NEUROSCIENCE

Origins and Proliferative States of Human Oligodendrocyte Precursor Cells

(2020) Wei Huang et al.   CELL

Oligodendrogenesis and Myelin Formation in the Forebrain Require Platelet-derived Growth Factor Receptor-alpha

(2020) Takeru Hamashima et al.   NEUROSCIENCE

Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age

(2019) Sonia Olivia Spitzer et al.   NEURON

Independent and cooperative roles of the Mek/ERK1/2-MAPK and PI3K/Akt/mTOR pathways during developmental myelination and in adulthood

(2019) Akihiro Ishii et al.   GLIA

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis

(2019) Qinjie Weng et al.   Cell Stem Cell

Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment

(2019) Anna C. Geraghty et al.   NEURON

Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFRα in Adult Brain

(2019) Thành Chung Đặng et al.   Cell Reports

Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity

(2019) Daisuke Kato et al.   GLIA

The Chromatin Environment Around Interneuron Genes in Oligodendrocyte Precursor Cells and Their Potential for Interneuron Reprograming

(2019) Linda L. Boshans et al.   Frontiers in Neuroscience

Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice

(2019) Patrick E. Steadman et al.   NEURON

Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis

(2019) David Orduz et al.   Nature Communications

Endothelin signalling mediates experience-dependent myelination in the CNS

(2019) Matthew Swire et al.   eLife

Conditional Deletion of LRP1 Leads to Progressive Loss of Recombined NG2-Expressing Oligodendrocyte Precursor Cells in a Novel Mouse Model

(2019) Ina Schäfer et al.   Cells

The effects of developmental and current niches on oligodendrocyte precursor dynamics and fate

(2019) Linda L. Boshans et al.   NEUROSCIENCE LETTERS

Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair

(2018) Chuntao Zhao et al.   DEVELOPMENTAL CELL

Activity-Dependent Myelination of Parvalbumin Interneurons Mediated by Axonal Morphological Plasticity

(2018) Jeffrey Stedehouder et al.   JOURNAL OF NEUROSCIENCE

Age-Dependent Decline in Fate Switch from NG2 Cells to Astrocytes After Olig2 Deletion

(2018) Hao Zuo et al.   JOURNAL OF NEUROSCIENCE

Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex

(2018) Ethan G. Hughes et al.   NATURE NEUROSCIENCE

Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain

(2018) Robert A. Hill et al.   NATURE NEUROSCIENCE

Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

(2018) Stanislaw Mitew et al.   Nature Communications

Oligodendrocytes in the Mouse Corpus Callosum Maintain Axonal Function by Delivery of Glucose

(2018) Niklas Meyer et al.   Cell Reports

General intelligence is associated with working memory-related brain activity: new evidence from a large sample study

(2018) Hikaru Takeuchi et al.   Brain Structure & Function

Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development

(2018) Sueli Marques et al.   DEVELOPMENTAL CELL

Length of myelin internodes of individual oligodendrocytes is controlled by microenvironment influenced by normal and input-deprived axonal activities in sensory deprived mouse models

(2018) Yasuyuki Osanai et al.   GLIA

Molecular and genetic evidence for the PDGFRα-independent population of OPCs in the developing mouse brain

(2018) Kang Zheng et al.   JOURNAL OF NEUROSCIENCE

Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8

(2018) Corentine Marie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis

(2018) Lu O. Sun et al.   CELL

The Lysosomal Transcription Factor TFEB Represses Myelination Downstream of the Rag-Ragulator Complex

(2018) Ana M. Meireles et al.   DEVELOPMENTAL CELL

NG2 expression in NG2 glia is regulated by binding of SoxE and bHLH transcription factors to a Cspg4 intronic enhancer

(2018) Hitoshi Gotoh et al.   GLIA

Brain-Derived Neurotrophic Factor in Central Nervous System Myelination: A New Mechanism to Promote Myelin Plasticity and Repair

(2018) Jessica Fletcher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In Vivo Regulation of Oligodendrocyte Precursor Cell Proliferation and Differentiation by the AMPA-Receptor Subunit GluA2

(2018) Ting-Jiun Chen et al.   Cell Reports

Thalamic Spindles Promote Memory Formation during Sleep through Triple Phase-Locking of Cortical, Thalamic, and Hippocampal Rhythms

(2017) Charles-Francois V. Latchoumane et al.   NEURON

Axonal Regulation of Central Nervous System Myelination: Structure and Function

(2017) Anna Klingseisen et al.   NEUROSCIENTIST

Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation

(2017) Nicolette Ognjanovski et al.   Nature Communications

Remarkable Stability of Myelinating Oligodendrocytes in Mice

(2017) Richa B. Tripathi et al.   Cell Reports

Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival

(2017) Eleni Kougioumtzidou et al.   eLife

Glioma-Derived Platelet-Derived Growth Factor-BB Recruits Oligodendrocyte Progenitor Cells via Platelet-Derived Growth Factor Receptor-α and Remodels Cancer Stroma

(2016) Yang Zheng et al.   AMERICAN JOURNAL OF PATHOLOGY

Adaptive myelination from fish to man

(2016) Marion Baraban et al.   BRAIN RESEARCH

SomethiNG 2 talk about—Transcriptional regulation in embryonic and adult oligodendrocyte precursors

(2016) Melanie Küspert et al.   BRAIN RESEARCH

Individual Neuronal Subtypes Exhibit Diversity in CNS Myelination Mediated by Synaptic Vesicle Release

(2016) Sigrid Koudelka et al.   CURRENT BIOLOGY

Dystroglycan Suppresses Notch to Regulate Stem Cell Niche Structure and Function in the Developing Postnatal Subventricular Zone

(2016) Freyja K. McClenahan et al.   DEVELOPMENTAL CELL

Heterogeneity of astrocyte and NG2 cell insertion at the node of ranvier

(2016) David R. Serwanski et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity

(2016) A. Etxeberria et al.   JOURNAL OF NEUROSCIENCE

Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning

(2016) Lin Xiao et al.   NATURE NEUROSCIENCE

Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism

(2016) Aiman S. Saab et al.   NEURON

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline

(2016) Abbe H. Crawford et al.   Cell Reports

A large fraction of neocortical myelin ensheathes axons of local inhibitory neurons

(2016) Kristina D Micheva et al.   eLife

Low Density Lipoprotein Receptor Related Proteins as Regulators of Neural Stem and Progenitor Cell Function

(2016) Loic Auderset et al.   Stem Cells International

CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes

(2015) Marie E. Bechler et al.   CURRENT BIOLOGY

Olig1 Function Is Required for Oligodendrocyte Differentiation in the Mouse Brain

(2015) J. Dai et al.   JOURNAL OF NEUROSCIENCE

Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration

(2015) S. Moyon et al.   JOURNAL OF NEUROSCIENCE

Brg1-Dependent Chromatin Remodelling Is Not Essentially Required during Oligodendroglial Differentiation

(2015) M. Bischof et al.   JOURNAL OF NEUROSCIENCE

Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo

(2015) Sigrid Mensch et al.   NATURE NEUROSCIENCE

Neuronal activity biases axon selection for myelination in vivo

(2015) Jacob H Hines et al.   NATURE NEUROSCIENCE

Acceleration of conduction velocity linked to clustering of nodal components precedes myelination

(2015) Sean A. Freeman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain

(2014) Maggie S.Y. Yeung et al.   CELL

Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS

(2014) Q. Zhu et al.   DEVELOPMENT

Novel NG2-CreERT2 knock-in mice demonstrate heterogeneous differentiation potential of NG2 glia during development

(2014) Wenhui Huang et al.   GLIA

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

NG2-Glia from Pallial Progenitors Produce the Largest Clonal Clusters of the Brain: Time Frame of Clonal Generation in Cortex and Olfactory Bulb

(2014) J. Garcia-Marques et al.   JOURNAL OF NEUROSCIENCE

Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division

(2014) Robert A Hill et al.   NATURE NEUROSCIENCE

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

Neuregulin and BDNF Induce a Switch to NMDA Receptor-Dependent Myelination by Oligodendrocytes

(2014) Iben Lundgaard et al.   PLOS BIOLOGY

Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation

(2013) Yang Yu et al.   CELL

NG2 Cells in White Matter But Not Gray Matter Proliferate in Response to PDGF

(2013) R. A. Hill et al.   JOURNAL OF NEUROSCIENCE

Motor Skill Learning Induces Changes in White Matter Microstructure and Myelination

(2013) C. Sampaio-Baptista et al.   JOURNAL OF NEUROSCIENCE

Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain

(2013) Francesca Viganò et al.   NATURE NEUROSCIENCE

Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling

(2013) Kaylene M. Young et al.   NEURON

The Theta-Gamma Neural Code

(2013) John E. Lisman et al.   NEURON

White matter plasticity in adulthood

(2013) S. Wang et al.   NEUROSCIENCE

Role of myelin plasticity in oscillations and synchrony of neuronal activity

(2013) S. Pajevic et al.   NEUROSCIENCE

Olig2-dependent developmental fate switch of NG2 cells

(2012) X. Zhu et al.   DEVELOPMENT

White Matter Structure Changes as Adults Learn a Second Language

(2012) Alexander A. Schlegel et al.   JOURNAL OF COGNITIVE NEUROSCIENCE

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Impaired adult myelination in the prefrontal cortex of socially isolated mice

(2012) Jia Liu et al.   NATURE NEUROSCIENCE

A Critical Period for Social Experience-Dependent Oligodendrocyte Maturation and Myelination

(2012) M. Makinodan et al.   SCIENCE

Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas

(2011) Caroline Pellet-Many et al.   BIOCHEMICAL JOURNAL

Age-dependent fate and lineage restriction of single NG2 cells

(2011) X. Zhu et al.   DEVELOPMENT

Dorsally and Ventrally Derived Oligodendrocytes Have Similar Electrical Properties but Myelinate Preferred Tracts

(2011) R. B. Tripathi et al.   JOURNAL OF NEUROSCIENCE

Brain Abnormalities and Glioma-Like Lesions in Mice Overexpressing the Long Isoform of PDGF-A in Astrocytic Cells

(2011) Inga Nazarenko et al.   PLoS One

Control of Local Protein Synthesis and Initial Events in Myelination by Action Potentials

(2011) H. Wake et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Working memory

(2010) Alan Baddeley   CURRENT BIOLOGY

Control of oligodendroglial cell number by the miR-17-92 cluster

(2010) H. Budde et al.   DEVELOPMENT

Training of Working Memory Impacts Structural Connectivity

(2010) H. Takeuchi et al.   JOURNAL OF NEUROSCIENCE

Excitability and Synaptic Communication within the Oligodendrocyte Lineage

(2010) L. M. De Biase et al.   JOURNAL OF NEUROSCIENCE

Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum

(2010) Ainhoa Etxeberria et al.   NATURE NEUROSCIENCE

Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination

(2010) Jason C. Dugas et al.   NEURON

NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

(2010) Shin H. Kang et al.   NEURON

MicroRNA-Mediated Control of Oligodendrocyte Differentiation

(2010) Xianghui Zhao et al.   NEURON

Cell cycle dynamics of NG2 cells in the postnatal and ageing brain

(2010) Konstantina Psachoulia et al.   Neuron Glia Biology

Electrical stimulation of the medullary pyramid promotes proliferation and differentiation of oligodendrocyte progenitor cells in the corticospinal tract of the adult rat

(2010) Qun Li et al.   NEUROSCIENCE LETTERS

Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer

(2010) M. Kuspert et al.   NUCLEIC ACIDS RESEARCH

Activation of the Mammalian Target of Rapamycin (mTOR) Is Essential for Oligodendrocyte Differentiation

(2009) W. A. Tyler et al.   JOURNAL OF NEUROSCIENCE

Training induces changes in white-matter architecture

(2009) Jan Scholz et al.   NATURE NEUROSCIENCE

Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor   expression

(2008) M. Finzsch et al.   DEVELOPMENT

Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex

(2008) L. Dimou et al.   JOURNAL OF NEUROSCIENCE

Constitutively Active Akt Induces Enhanced Myelination in the CNS

(2008) A. I. Flores et al.   JOURNAL OF NEUROSCIENCE

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

(2008) Leanne E Rivers et al.   NATURE NEUROSCIENCE

Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter

(2008) Ragnhildur Káradóttir et al.   NATURE NEUROSCIENCE