Brain-Derived Neurotrophic Factor in Central Nervous System Myelination: A New Mechanism to Promote Myelin Plasticity and Repair

Myelin Plasticity and Nervous System Function

(2018) Michelle Monje   Annual Review of Neuroscience

Targeting TrkB with a brain-derived neurotrophic factor mimetic promotes myelin repair in the brain

(2018) Jessica L Fletcher et al.   JOURNAL OF NEUROSCIENCE

BDNF haploinsufficiency exerts a transient and regionally different influence upon oligodendroglial lineage cells during postnatal development

(2018) Madeline Nicholson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Functional Roles of Astrocyte Calcium Elevations: From Synapses to Behavior

(2018) Sónia Guerra-Gomes et al.   Frontiers in Cellular Neuroscience

Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

(2018) Stanislaw Mitew et al.   Nature Communications

Activity-dependent central nervous system myelination throughout life

(2018) Omar de Faria et al.   JOURNAL OF NEUROCHEMISTRY

The TAM receptor Tyro3 regulates myelination in the central nervous system

(2017) Rainer Akkermann et al.   GLIA

Signaling by FGF Receptor 2, Not FGF Receptor 1, Regulates Myelin Thickness through Activation of ERK1/2–MAPK, Which Promotes mTORC1 Activity in an Akt-Independent Manner

(2017) Miki Furusho et al.   JOURNAL OF NEUROSCIENCE

Achievements and obstacles of remyelinating therapies in multiple sclerosis

(2017) Martin Stangel et al.   Nature Reviews Neurology

Human neural stem/progenitor cells derived from the olfactory epithelium express the TrkB receptor and migrate in response to BDNF

(2017) Leonardo Ortiz-López et al.   NEUROSCIENCE

TrkB agonist, 7,8-dihydroxyflavone, reduces the clinical and pathological severity of a murine model of multiple sclerosis

(2016) Tapas K. Makar et al.   JOURNAL OF NEUROIMMUNOLOGY

Strength of ERK1/2 MAPK Activation Determines Its Effect on Myelin and Axonal Integrity in the Adult CNS

(2016) Akihiro Ishii et al.   JOURNAL OF NEUROSCIENCE

A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination

(2016) Sandra Goebbels et al.   NATURE NEUROSCIENCE

NMDA Receptors: Power Switches for Oligodendrocytes

(2016) Anna M. Krasnow et al.   NEURON

Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism

(2016) Aiman S. Saab et al.   NEURON

Brain-Derived Neurotrophic Factor Deficiency Restricts Proliferation of Oligodendrocyte Progenitors Following Cuprizone-Induced Demyelination

(2015) Vladislav Tsiperson et al.   ASN Neuro

CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes

(2015) Marie E. Bechler et al.   CURRENT BIOLOGY

Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination

(2015) Haley Peckham et al.   GLIA

Translational Control of Myelin Basic Protein Expression by ERK2 MAP Kinase Regulates Timely Remyelination in the Adult Brain

(2015) K. Michel et al.   JOURNAL OF NEUROSCIENCE

Neuronal activity biases axon selection for myelination in vivo

(2015) Jacob H Hines et al.   NATURE NEUROSCIENCE

Oligodendrocytes: Myelination and Axonal Support

(2015) Mikael Simons et al.   Cold Spring Harbor Perspectives in Biology

Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors

(2015) Hélène O. B. Gautier et al.   Nature Communications

Nonsynaptic junctions on myelinating glia promote preferential myelination of electrically active axons

(2015) Hiroaki Wake et al.   Nature Communications

Social Experience-Dependent Myelination: An Implication for Psychiatric Disorders

(2015) Michihiro Toritsuka et al.   NEURAL PLASTICITY

Myelination of the Nervous System: Mechanisms and Functions

(2014) Klaus-Armin Nave et al.   Annual Review of Cell and Developmental Biology

Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation

(2014) JinXiang Dai et al.   GLIA

Stage-Specific Regulation of Oligodendrocyte Development by Wnt/ -Catenin Signaling

(2014) Z.-M. Dai et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-Derived BDNF Supports Myelin Protein Synthesis after Cuprizone-Induced Demyelination

(2014) C. G. Fulmer et al.   JOURNAL OF NEUROSCIENCE

Role of ERK1/2 MAPK Signaling in the Maintenance of Myelin and Axonal Integrity in the Adult CNS

(2014) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

Adult Neural Precursor Cells from the Subventricular Zone Contribute Significantly to Oligodendrocyte Regeneration and Remyelination

(2014) Y. L. Xing et al.   JOURNAL OF NEUROSCIENCE

TDP6, a brain-derived neurotrophic factor-based trkB peptide mimetic, promotes oligodendrocyte myelination

(2014) Agnes W. Wong et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Essential Role of Presynaptic NMDA Receptors in Activity-Dependent BDNF Secretion and Corticostriatal LTP

(2014) Hyungju Park et al.   NEURON

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

Neuregulin and BDNF Induce a Switch to NMDA Receptor-Dependent Myelination by Oligodendrocytes

(2014) Iben Lundgaard et al.   PLOS BIOLOGY

Nanofibers Support Oligodendrocyte Precursor Cell Growth and Function as a Neuron-Free Model for Myelination Study

(2013) Yongchao Li et al.   BIOMACROMOLECULES

Sustained Activation of ERK1/2 MAPK in Oligodendrocytes and Schwann Cells Enhances Myelin Growth and Stimulates Oligodendrocyte Progenitor Expansion

(2013) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

Oligodendroglial Expression of TrkB Independently Regulates Myelination and Progenitor Cell Proliferation

(2013) A. W. Wong et al.   JOURNAL OF NEUROSCIENCE

A rapid and reproducible assay for modeling myelination by oligodendrocytes using engineered nanofibers

(2013) Seonok Lee et al.   Nature Protocols

Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease

(2013) Frank M. Longo et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanisms regulating the development of oligodendrocytes and central nervous system myelin

(2013) S. Mitew et al.   NEUROSCIENCE

Brain-Derived Neurotrophic Factor Promotes Vasculature-Associated Migration of Neuronal Precursors toward the Ischemic Striatum

(2013) Sofia Grade et al.   PLoS One

Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration

(2012) Emanuela Colombo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extracellular signal-regulated kinase 1/2 signaling promotes oligodendrocyte myelination in vitro

(2012) Junhua Xiao et al.   JOURNAL OF NEUROCHEMISTRY

ERK1/ERK2 MAPK Signaling is Required to Increase Myelin Thickness Independent of Oligodendrocyte Differentiation and Initiation of Myelination

(2012) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

A culture system to study oligodendrocyte myelination processes using engineered nanofibers

(2012) Seonok Lee et al.   NATURE METHODS

Brain-Derived Neurotrophic Factor: A Dynamic Gatekeeper of Neural Plasticity

(2012) Kiriana Cowansage et al.   Current Molecular Pharmacology

Erk1/2 MAPK and mTOR signaling sequentially regulates progression through distinct stages of oligodendrocyte differentiation

(2011) Hebe M. Guardiola-Diaz et al.   GLIA

Levels of BDNF Impact Oligodendrocyte Lineage Cells following a Cuprizone Lesion

(2011) M. W. VonDran et al.   JOURNAL OF NEUROSCIENCE

Critical appraisal of animal models of multiple sclerosis

(2011) David Baker et al.   Multiple Sclerosis Journal

Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity

(2011) Jing Chen et al.   NEUROSCIENCE LETTERS

Epigenetic modifications induced by early enrichment are associated with changes in timing of induction of BDNF expression

(2011) Igor Branchi et al.   NEUROSCIENCE LETTERS

Brain-Derived Neurotrophic Factor Promotes Central Nervous System Myelination via a Direct Effect upon Oligodendrocytes

(2011) Junhua Xiao et al.   NEUROSIGNALS

Control of Local Protein Synthesis and Initial Events in Myelination by Action Potentials

(2011) H. Wake et al.   SCIENCE

CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination

(2010) Malgorzata Zawadzka et al.   Cell Stem Cell

Transcriptional and post-transcriptional control of CNS myelination

(2010) Ben Emery   CURRENT OPINION IN NEUROBIOLOGY

BDNF+/− mice exhibit deficits in oligodendrocyte lineage cells of the basal forebrain

(2010) Melissa W. Vondran et al.   GLIA

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

(2010) Stephen M. Massa et al.   JOURNAL OF CLINICAL INVESTIGATION

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

(2010) S.-W. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Oligodendrocyte Differentiation and Myelination

(2010) B. Emery   SCIENCE

Modified low molecular weight cyclic peptides as mimetics of BDNF with improved potency, proteolytic stability and transmembrane passage in vitro

(2009) Jordan M. Fletcher et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

(2009) S. P.J. Fancy et al.   GENES & DEVELOPMENT

Neurotrophins Induce Neuregulin Release through Protein Kinase Cδ Activation

(2009) Raymond M. Esper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Activity-Dependent Secretion of Brain-Derived Neurotrophic Factor from Axon and Dendrite

(2009) N. Matsuda et al.   JOURNAL OF NEUROSCIENCE

New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

(2009) M. E. Greenberg et al.   JOURNAL OF NEUROSCIENCE

BDNF Exerts Contrasting Effects on Peripheral Myelination of NGF-Dependent and BDNF-Dependent DRG Neurons

(2009) J. Xiao et al.   JOURNAL OF NEUROSCIENCE

Glutamate elicits release of BDNF from basal forebrain astrocytes in a process dependent on metabotropic receptors and the PLC pathway

(2009) Ying Y. Jean et al.   Neuron Glia Biology

Three-Dimensional Nanofibrous Scaffolds Incorporating Immobilized BDNF Promote Proliferation and Differentiation of Cortical Neural Stem Cells

(2009) Malcolm K. Horne et al.   STEM CELLS AND DEVELOPMENT

Constitutively Active Akt Induces Enhanced Myelination in the CNS

(2008) A. I. Flores et al.   JOURNAL OF NEUROSCIENCE

Brain-derived neurotrophic factor effects on oligodendrocyte progenitors of the basal forebrain are mediated through trkB and the MAP kinase pathway

(2008) Ashlee Van't Veer et al.   JOURNAL OF NEUROSCIENCE RESEARCH

TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment

(2008) Yun Li et al.   NEURON

White matter in learning, cognition and psychiatric disorders

(2008) R. Douglas Fields   TRENDS IN NEUROSCIENCES

Role of the brain-derived neurotrophic factor at glutamatergic synapses

(2007) A L Carvalho et al.   BRITISH JOURNAL OF PHARMACOLOGY