Arsenic-induced epigenetic changes in cancer development

Arsenic: A Global Environmental Challenge

(2021) Qiao Yi Chen et al.   Annual Review of Pharmacology and Toxicology

TET-mediated DNA demethylation plays an important role in arsenic-induced HBE cells oxidative stress via regulating promoter methylation of OGG1 and GSTP1

(2021) Qingling Wang et al.   TOXICOLOGY IN VITRO

Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming

(2020) Dominic G. Roy et al.   Cell Metabolism

CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention

(2020) Elena M. Pugacheva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Splicing dysregulation in cancer: from mechanistic understanding to a new class of therapeutic targets

(2020) Yongbo Wang et al.   Science China-Life Sciences

The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing

(2020) Xiaohui Hu et al.   Nature Communications

Arsenite Exposure Displaces Zinc from ZRANB2 Leading to Altered Splicing

(2020) Mayukh Banerjee et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome

(2020) Sara Cherry et al.   GENES & DEVELOPMENT

The role of alternative splicing in cancer: From oncogenesis to drug resistance

(2020) Rocco Sciarrillo et al.   DRUG RESISTANCE UPDATES

Arsenic-induced changes in miRNA expression in cancer and other diseases

(2020) Ana P. Ferragut Cardoso et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing

(2019) Elena A. Matveeva et al.   Epigenetics & Chromatin

Developmental neurotoxicity of inorganic arsenic exposure in Sprague-Dawley rats

(2019) Christopher L. Moore et al.   NEUROTOXICOLOGY AND TERATOLOGY

The expanding landscape of ‘oncohistone’ mutations in human cancers

(2019) Benjamin A. Nacev et al.   NATURE

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3

(2019) Lorna A. Farrelly et al.   NATURE

Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L

(2019) Evan J. Worden et al.   CELL

Emerging roles of histone modifications and HDACs in RNA splicing

(2019) Raneen Rahhal et al.   NUCLEIC ACIDS RESEARCH

Histone H3 Mutations: An Updated View of Their Role in Chromatin Deregulation and Cancer

(2019) Brandon R. Lowe et al.   Cancers

DNA Methylation Readers and Cancer: Mechanistic and Therapeutic Applications

(2019) Niaz Mahmood et al.   Frontiers in Oncology

Histone chaperone exploits intrinsic disorder to switch acetylation specificity

(2019) Nataliya Danilenko et al.   Nature Communications

Developmental Neurotoxicity of Arsenic: Involvement of Oxidative Stress and Mitochondrial Functions

(2018) Lalit P. Chandravanshi et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics

(2018) Ibraheem Ali et al.   CHEMICAL REVIEWS

Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation

(2018) Tao Li et al.   NUCLEIC ACIDS RESEARCH

The Importance of DNA Methylation of Exons on Alternative Splicing

(2018) Ronna Shayevitch et al.   RNA

Selective inhibition of CTCF binding by iAs directs TET-mediated reprogramming of 5-hydroxymethylation patterns in iAs-transformed cells

(2018) Matthew Rea et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mapping dynamic histone modification patterns during arsenic-induced malignant transformation of human bladder cells

(2018) Yichen Ge et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A review on arsenic carcinogenesis: Epidemiology, metabolism, genotoxicity and epigenetic changes

(2018) Qing Zhou et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Enhanced histone H3K9 tri-methylation suppresses steroidogenesis in rat testis chronically exposed to arsenic

(2018) Ambreen Alamdar et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance

(2017) Satoshi Ishiyama et al.   MOLECULAR CELL

TET-mediated active DNA demethylation: mechanism, function and beyond

(2017) Xiaoji Wu et al.   NATURE REVIEWS GENETICS

Variants of core histones and their roles in cell fate decisions, development and cancer

(2017) Marcus Buschbeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased microRNA 21 expression contributes to arsenic induced skin lesions, skin cancers and respiratory distress in chronically exposed individuals

(2017) Nilanjana Banerjee et al.   TOXICOLOGY

Transient and permanent changes in DNA methylation patterns in inorganic arsenic-mediated epithelial-to-mesenchymal transition

(2017) Meredith Eckstein et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells

(2017) Chengzhi Chen et al.   TOXICOLOGY LETTERS

Disruption of the 3D cancer genome blueprint

(2017) Joanna Achinger-Kawecka et al.   Epigenomics

Site-specific ADP-ribosylation of histone H2B in response to DNA double strand breaks

(2017) Alina Rakhimova et al.   Scientific Reports

Epigenomic reprogramming in inorganic arsenic-mediated gene expression patterns during carcinogenesis

(2017) Meredith Eckstein et al.   REVIEWS ON ENVIRONMENTAL HEALTH

Genome-wide DNA methylation reprogramming in response to inorganic arsenic links inhibition of CTCF binding, DNMT expression and cellular transformation

(2017) Matthew Rea et al.   Scientific Reports

Role of TET enzymes in DNA methylation, development, and cancer

(2016) Kasper Dindler Rasmussen et al.   GENES & DEVELOPMENT

Quantitative Mass Spectrometry Reveals Changes in Histone H2B Variants as Cells Undergo Inorganic Arsenic-Mediated Cellular Transformation

(2016) Matthew Rea et al.   MOLECULAR & CELLULAR PROTEOMICS

Specific histone modification responds to arsenic-induced oxidative stress

(2016) Lu Ma et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

MicroRNA-21 activation of ERK signaling via PTEN is involved in arsenite-induced autophagy in human hepatic L-02 cells

(2016) Xinlu Liu et al.   TOXICOLOGY LETTERS

Comparative analysis of linker histone H1, MeCP2, and HMGD1 on nucleosome stability and target site accessibility

(2016) Caitlyn Riedmann et al.   Scientific Reports

Involvement of PARP1 in the regulation of alternative splicing

(2016) Elena Matveeva et al.   Cell Discovery

Regulation of Alternative Splicing Through Coupling with Transcription and Chromatin Structure

(2015) Shiran Naftelberg et al.   Annual Review of Biochemistry

A Potential New Mechanism of Arsenic Carcinogenesis: Depletion of Stem-Loop Binding Protein and Increase in Polyadenylated Canonical Histone H3.1 mRNA

(2015) Jason Brocato et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Inorganic Arsenic-induced cellular transformation is coupled with genome wide changes in chromatin structure, transcriptome and splicing patterns

(2015) Caitlyn Riedmann et al.   BMC GENOMICS

Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors

(2015) Amy L. Walz et al.   CANCER CELL

Involvement of Epigenetics and EMT-Related miRNA in Arsenic-Induced Neoplastic Transformation and Their Potential Clinical Use

(2015) C. Michailidi et al.   Cancer Prevention Research

The H1 linker histones: multifunctional proteins beyond the nucleosomal core particle

(2015) S. P. Hergeth et al.   EMBO REPORTS

E2F1-Mediated FOS Induction in Arsenic Trioxide–Induced Cellular Transformation: Effects of Global H3K9 Hypoacetylation and Promoter-Specific Hyperacetylation in Vitro

(2015) Sunniyat Rahman et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Arsenite Targets the Zinc Finger Domains of Tet Proteins and Inhibits Tet-Mediated Oxidation of 5-Methylcytosine

(2015) Shuo Liu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

CTCF-binding site orientation shapes the genome

(2015) Eytan Zlotorynski   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Arsenic Trioxide Reduces Global Histone H4 Acetylation at Lysine 16 through Direct Binding to Histone Acetyltransferase hMOF in Human Cells

(2015) Da Liu et al.   PLoS One

Developmental exposure to 50 parts-per-billion arsenic influences histone modifications and associated epigenetic machinery in a region- and sex-specific manner in the adult mouse brain

(2015) Christina R. Tyler et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Arsenic responsive microRNAs in vivo and their potential involvement in arsenic-induced oxidative stress

(2015) Xuefeng Ren et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

MicroRNA-21, up-regulated by arsenite, directs the epithelial–mesenchymal transition and enhances the invasive potential of transformed human bronchial epithelial cells by targeting PDCD4

(2015) Fei Luo et al.   TOXICOLOGY LETTERS

The alternative role of DNA methylation in splicing regulation

(2015) Galit Lev Maor et al.   TRENDS IN GENETICS

HP1 Is Involved in Regulating the Global Impact of DNA Methylation on Alternative Splicing

(2015) Ahuvi Yearim et al.   Cell Reports

Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation

(2015) Narasimharao Nalabothula et al.   PLoS One

On the presence and role of human gene-body DNA methylation

(2015) Daudi Jjingo et al.   Oncotarget

Arsenic Trioxide Inhibits DNA Methyltransferase and Restores TMS1 Gene Expression in K562 Cells

(2014) Hongli Li et al.   ACTA HAEMATOLOGICA

Playing TETris with DNA modifications

(2014) B. Delatte et al.   EMBO JOURNAL

Chronic Arsenic Exposure and Angiogenesis in Human Bronchial Epithelial Cells via the ROS/miR-199a-5p/HIF-1α/COX-2 Pathway

(2014) Jun He et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Arsenic Induces Polyadenylation of Canonical Histone mRNA by Down-regulating Stem-Loop-binding Protein Gene Expression

(2014) Jason Brocato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone H1 Phosphorylation in Breast Cancer

(2014) Sean W. Harshman et al.   JOURNAL OF PROTEOME RESEARCH

HuR Regulates Alternative Splicing of the TRA2  Gene in Human Colon Cancer Cells under Oxidative Stress

(2014) Y. Akaike et al.   MOLECULAR AND CELLULAR BIOLOGY

Citrullination regulates pluripotency and histone H1 binding to chromatin

(2014) Maria A. Christophorou et al.   NATURE

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Developmental Neurotoxicity of Arsenic: Cognitive and Behavioral Consequences of Early Life Exposure

(2014) Molly Tolins et al.   Annals of Global Health

Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition

(2013) Alika K Maunakea et al.   CELL RESEARCH

SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase

(2013) Murilo TD Bueno et al.   Epigenetics

DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon-intron structure

(2013) S. Gelfman et al.   GENOME RESEARCH

Genome-Wide Alteration of Histone H3K9 Acetylation Pattern in Mouse Offspring Prenatally Exposed to Arsenic

(2013) Andrea A. Cronican et al.   PLoS One

Inhibition of monomethylarsonous acid (MMAIII)-induced cell malignant transformation through restoring dysregulated histone acetylation

(2013) Yichen Ge et al.   TOXICOLOGY

Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells

(2013) Fei Luo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Associations between Arsenic Exposure and Global Posttranslational Histone Modifications among Adults in Bangladesh

(2012) Y. Chervona et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Associations between microRNA (miR-21, 126, 155 and 221), albuminuria and heavy metals in Hong Kong Chinese adolescents

(2012) Alice P.S. Kong et al.   CLINICA CHIMICA ACTA

Epigenetic targets of some toxicologically relevant metals: a review of the literature

(2012) Tsu-Fan Cheng et al.   JOURNAL OF APPLIED TOXICOLOGY

Polycomb (PcG) Proteins, BMI1 and SUZ12, Regulate Arsenic-induced Cell Transformation

(2012) Hong-Gyum Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Environmental arsenic exposure and DNA methylation of the tumor suppressor gene p16 and the DNA repair gene MLH1: effect of arsenic metabolism and genotype

(2012) Mohammad Bakhtiar Hossain et al.   Metallomics

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

Effects of Chronic Exposure to Arsenic and Estrogen on Epigenetic Regulatory Genes Expression and Epigenetic Code in Human Prostate Epithelial Cells

(2012) Justin N. Treas et al.   PLoS One

Poly(ADP-ribosyl)ation Acts in the DNA Demethylation of Mouse Primordial Germ Cells Also with DNA Damage-Independent Roles

(2012) Fabio Ciccarone et al.   PLoS One

Environmental factors in causing human cancers: emphasis on tumorigenesis

(2012) Umesh T. Sankpal et al.   TUMOR BIOLOGY

Psip1/Ledgf p52 Binds Methylated Histone H3K36 and Splicing Factors and Contributes to the Regulation of Alternative Splicing

(2012) Madapura M. Pradeepa et al.   PLoS Genetics

ADP-ribose polymers localized on Ctcf–Parp1–Dnmt1 complex prevent methylation of Ctcf target sites

(2011) Michele Zampieri et al.   BIOCHEMICAL JOURNAL

Inhalable Metal-Rich Air Particles and Histone H3K4 Dimethylation and H3K9 Acetylation in a Cross-sectional Study of Steel Workers

(2011) Laura Cantone et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Global Levels of Histone Modifications in Peripheral Blood Mononuclear Cells of Subjects with Exposure to Nickel

(2011) Adriana Arita et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response

(2011) Jayne E.P. Loughery et al.   HUMAN MOLECULAR GENETICS

Arsenite Interacts Selectively with Zinc Finger Proteins Containing C3H1 or C4 Motifs

(2011) Xixi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OPERating ON Chromatin, a Colorful Language where Context Matters

(2011) Kathryn E. Gardner et al.   JOURNAL OF MOLECULAR BIOLOGY

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

(2011) Sanjeev Shukla et al.   NATURE

Exposure to Metal-Rich Particulate Matter Modifies the Expression of Candidate MicroRNAs in Peripheral Blood Leukocytes

(2010) Valentina Bollati et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation

(2010) J. Song et al.   SCIENCE

Effects of MEK and DNMT inhibitors on arsenic-treated human uroepithelial cells in relation to Cyclin-D1 and p16

(2010) Ya-Chun Huang et al.   TOXICOLOGY LETTERS

Effects of arsenic exposure on DNA methylation and epigenetic gene regulation

(2010) John F Reichard et al.   Epigenomics

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging

(2009) Kyong-chol Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Insulin Gene Expression Is Regulated by DNA Methylation

(2009) Akio Kuroda et al.   PLoS One

Arsenic Activates EGFR Pathway Signaling in the Lung

(2009) Angeline S. Andrew et al.   TOXICOLOGICAL SCIENCES

Effects of nickel, chromate, and arsenite on histone 3 lysine methylation

(2009) Xue Zhou et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure

(2009) William Jaime Jo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nucleophosmin in the pathogenesis of arsenic-related bladder carcinogenesis revealed by quantitative proteomics

(2009) Shu-Hui Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Epigenetic remodeling during arsenical-induced malignant transformation

(2008) Taylor J. Jensen et al.   CARCINOGENESIS

Arsenite alters global histone H3 methylation

(2008) X. Zhou et al.   CARCINOGENESIS

Epigenetics: poly(ADP-ribosyl)ation of PARP-1 regulates genomic methylation patterns

(2008) Paola Caiafa et al.   FASEB JOURNAL

Regulation of DNA methylation activity through Dnmt3L promoter methylation by Dnmt3 enzymes in embryonic development

(2008) Ye-Guang Hu et al.   HUMAN MOLECULAR GENETICS

Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline

(2008) Vincent Dion et al.   HUMAN MOLECULAR GENETICS

Interplay between Cellular Methyl Metabolism and Adaptive Efflux during Oncogenic Transformation from Chronic Arsenic Exposure in Human Cells

(2008) Jean-François Coppin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A microRNA DNA methylation signature for human cancer metastasis

(2008) A. Lujambio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation

(2008) Taylor J. Jensen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY