iPSC–endothelial cell phenotypic drug screening and in silico analyses identify tyrphostin-AG1296 for pulmonary arterial hypertension
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Title
iPSC–endothelial cell phenotypic drug screening and in silico analyses identify tyrphostin-AG1296 for pulmonary arterial hypertension
Authors
Keywords
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Journal
Science Translational Medicine
Volume 13, Issue 592, Pages eaba6480
Publisher
American Association for the Advancement of Science (AAAS)
Online
2021-05-06
DOI
10.1126/scitranslmed.aba6480
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Note: Only part of the references are listed.- Potential Adverse Effects of Resveratrol: A Literature Review
- (2020) Abdullah Shaito et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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- (2020) Lai-Ming Yung et al. Science Translational Medicine
- Generation of Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem-Cell-Derived Venous Angioblasts
- (2020) Blair K. Gage et al. Cell Stem Cell
- TMEM16A Regulates Pulmonary Arterial Smooth Muscle Cells Proliferation via p38MAPK/ERK Pathway in High Pulmonary Blood Flow-Induced Pulmonary Arterial Hypertension
- (2020) Dongli Liu et al. JOURNAL OF VASCULAR RESEARCH
- Smooth Muscle Contact Drives Endothelial Regeneration by BMPR2-Notch1–Mediated Metabolic and Epigenetic Changes
- (2019) Kazuya Miyagawa et al. CIRCULATION RESEARCH
- Induced pluripotent stem cells in disease modelling and drug discovery
- (2019) R. Grant Rowe et al. NATURE REVIEWS GENETICS
- The Search for Disease-Modifying Therapies in Pulmonary Hypertension
- (2019) Chen-Shan Chen Woodcock et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
- Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension
- (2019) Ryo Kurosawa et al. CIRCULATION RESEARCH
- Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension
- (2018) Kurt R Stenmark et al. CARDIOVASCULAR RESEARCH
- Drug screening for human genetic diseases using iPSC models
- (2018) Matthew S Elitt et al. HUMAN MOLECULAR GENETICS
- Fragile Histidine Triad (FHIT), a Novel Modifier Gene in Pulmonary Arterial Hypertension
- (2018) Svenja Dannewitz Prosseda et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Randomised placebo-controlled safety and tolerability trial of FK506 (tacrolimus) for pulmonary arterial hypertension
- (2017) Edda Spiekerkoetter et al. EUROPEAN RESPIRATORY JOURNAL
- FOXM1 promotes pulmonary artery smooth muscle cell expansion in pulmonary arterial hypertension
- (2017) Alice Bourgeois et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Shear Stress Counteracts Endothelial CX3CL1 Induction and Monocytic Cell Adhesion
- (2017) Aaron Babendreyer et al. MEDIATORS OF INFLAMMATION
- High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells
- (2017) Arun Sharma et al. Science Translational Medicine
- IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis
- (2017) Iuliia O. Peshkova et al. Scientific Reports
- Follistatin-like 1 protects against hypoxia-induced pulmonary hypertension in mice
- (2017) Wei Zhang et al. Scientific Reports
- Deterioration of pulmonary hypertension and pleural effusion with bosutinib following dasatinib lung toxicity
- (2016) Marianne Riou et al. EUROPEAN RESPIRATORY JOURNAL
- Pulmonary hypertension associated with ponatinib therapy: TABLE 1
- (2016) Fleur-Marie Quilot et al. EUROPEAN RESPIRATORY JOURNAL
- Bosutinib therapy resulting in severe deterioration of pre-existing pulmonary arterial hypertension
- (2016) Peter M. Hickey et al. EUROPEAN RESPIRATORY JOURNAL
- Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension
- (2016) Christophe Guignabert et al. JOURNAL OF CLINICAL INVESTIGATION
- Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension
- (2016) Thomas Bertero et al. JOURNAL OF CLINICAL INVESTIGATION
- The role of tyrosine kinase inhibitor “Lapatinib” in pulmonary hypertension
- (2016) Yaser Alkhatib et al. PULMONARY PHARMACOLOGY & THERAPEUTICS
- Elafin Reverses Pulmonary Hypertension via Caveolin-1–Dependent Bone Morphogenetic Protein Signaling
- (2015) Nils P. Nickel et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Occlusive Lung Arterial Lesions in Endothelial-Targeted, Fas-Induced Apoptosis Transgenic Mice
- (2015) Heather Goldthorpe et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- BMPR2 Preserves Mitochondrial Function and DNA during Reoxygenation to Promote Endothelial Cell Survival and Reverse Pulmonary Hypertension
- (2015) Isabel Diebold et al. Cell Metabolism
- Resveratrol alters human endothelial cells redox state and causes mitochondrial-dependent cell death
- (2015) Anna Maria Posadino et al. FOOD AND CHEMICAL TOXICOLOGY
- Flow-induced protein kinase A–CREB pathway acts via BMP signaling to promote HSC emergence
- (2015) Peter Geon Kim et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells
- (2015) Christoph Patsch et al. NATURE CELL BIOLOGY
- Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension
- (2015) Lu Long et al. NATURE MEDICINE
- Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension
- (2015) Abdul Q. Sheikh et al. Science Translational Medicine
- The Role of Vascular Endothelial Growth Factor in Pulmonary Arterial Hypertension. The Angiogenesis Paradox
- (2014) Norbert F. Voelkel et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- HTSeq--a Python framework to work with high-throughput sequencing data
- (2014) S. Anders et al. BIOINFORMATICS
- Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension
- (2014) Marlene Rabinovitch et al. CIRCULATION RESEARCH
- Effect of imatinib as add-on therapy on echocardiographic measures of right ventricular function in patients with significant pulmonary arterial hypertension
- (2014) A. M. Shah et al. EUROPEAN HEART JOURNAL
- Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension
- (2014) Hirofumi Sawada et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Human Stem Cells for Modeling Heart Disease and for Drug Discovery
- (2014) E. Matsa et al. Science Translational Medicine
- Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension
- (2013) Marius M. Hoeper et al. CIRCULATION
- FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension
- (2013) Edda Spiekerkoetter et al. JOURNAL OF CLINICAL INVESTIGATION
- Tyrosine Kinase Inhibitors in Pulmonary Arterial Hypertension: A Double-Edge Sword?
- (2013) Laurent Godinas et al. SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
- Missense Mutations of the BMPR1B (ALK6) Gene in Childhood Idiopathic Pulmonary Arterial Hypertension
- (2012) Ayako Chida et al. CIRCULATION JOURNAL
- Induced Pluripotent Stem Cells as a Disease Modeling and Drug Screening Platform
- (2012) Antje D. Ebert et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- NCBI GEO: archive for functional genomics data sets—update
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- Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis
- (2011) Pablo J Fernandez-Marcos et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Cyclic AMP response element-binding protein prevents endothelial permeability increase through transcriptional controlling p190RhoGAP expression
- (2011) K. R. Chava et al. BLOOD
- Disruption of PPARγ/β-catenin–mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
- (2011) Tero-Pekka Alastalo et al. JOURNAL OF CLINICAL INVESTIGATION
- Apelin and Pulmonary Hypertension
- (2011) Charlotte U. Andersen et al. Pulmonary Circulation
- Imatinib in Pulmonary Arterial Hypertension Patients with Inadequate Response to Established Therapy
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- Kruppel-like Factor 15 Regulates Smooth Muscle Response to Vascular Injury—Brief Report
- (2010) Yuan Lu et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
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- (2009) Jing Chen et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Molecular pathogenesis of pulmonary arterial hypertension
- (2008) Marlene Rabinovitch JOURNAL OF CLINICAL INVESTIGATION
- An antiproliferative BMP-2/PPARγ/apoE axis in human and murine SMCs and its role in pulmonary hypertension
- (2008) Georg Hansmann et al. JOURNAL OF CLINICAL INVESTIGATION
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