Immunity to Pathogens Taught by Specialized Human Dendritic Cell Subsets

The messenger's great message for vaccination

(2015) Steve Pascolo   Expert Review of Vaccines

Klf4 Expression in Conventional Dendritic Cells Is Required for T Helper 2 Cell Responses

(2015) Roxane Tussiwand et al.   IMMUNITY

Modular expression analysis reveals functional conservation between human Langerhans cells and mouse cross-priming dendritic cells

(2015) Maxim N. Artyomov et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow

(2015) Jaeyop Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Circulating precursors of human CD1c+and CD141+dendritic cells

(2015) Gaëlle Breton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Synchronization of IRF1, JunB, and C/EBPβ Activities during TLR3–TLR7 Cross-Talk Orchestrates Timely Cytokine Synergy in the Proinflammatory Response

(2015) Qian Liu et al.   JOURNAL OF IMMUNOLOGY

NOD-Like Receptors: Versatile Cytosolic Sentinels

(2015) Vinicius Motta et al.   PHYSIOLOGICAL REVIEWS

Regulation of Dendritic Cell Function in Inflammation

(2015) André Said et al.   Journal of Immunology Research

Cross-presenting dendritic cells are required for control ofLeishmania majorinfection

(2014) Devika Ashok et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8+T-cell cross-priming

(2014) Cynthia M. Fehres et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Dermal CD14 + Cells Are a Transient Population of Monocyte-Derived Macrophages

(2014) Naomi McGovern et al.   IMMUNITY

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

(2014) Timotheus Y.F. Halim et al.   IMMUNITY

Development and Function of Dendritic Cell Subsets

(2014) Alexander Mildner et al.   IMMUNITY

Human CD141+Dendritic Cells Induce CD4+T Cells To Produce Type 2 Cytokines

(2014) Chun I. Yu et al.   JOURNAL OF IMMUNOLOGY

Differential Ability of Surface and Endosomal TLRs To Induce CD8 T Cell Responses In Vivo

(2014) R. Mandraju et al.   JOURNAL OF IMMUNOLOGY

Paramyxovirus Infection Regulates T Cell Responses by BDCA-1+ and BDCA-3+ Myeloid Dendritic Cells

(2014) Meera R. Gupta et al.   PLoS One

Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

(2014) Julia Scheiermann et al.   VACCINE

Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines

(2014) Romain Banchereau et al.   Nature Communications

Communication between Human Dendritic Cell Subsets in Tuberculosis: Requirements for Naive CD4+ T Cell Stimulation

(2014) Laura Lozza et al.   Frontiers in Immunology

CD141+ dendritic cells produce prominent amounts of IFN-  after dsRNA recognition and can be targeted via DEC-205 in humanized mice

(2013) S. Meixlsperger et al.   BLOOD

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses

(2013) G. Nizzoli et al.   BLOOD

Human dendritic cells - stars in the skin

(2013) Eynav Klechevsky   EUROPEAN JOURNAL OF IMMUNOLOGY

Crosstalk between human DC subsets promotes antibacterial activity and CD8+T-cell stimulation in response to bacille Calmette-Guérin

(2013) Laura Lozza et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation

(2013) Elodie Segura et al.   IMMUNITY

Similar antigen cross-presentation capacity and phagocytic functions in all freshly isolated human lymphoid organ–resident dendritic cells

(2013) Elodie Segura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+dendritic cells at cross presentation

(2013) Lillian Cohn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice

(2013) Payal B Watchmaker et al.   NATURE IMMUNOLOGY

TH2, allergy and group 2 innate lymphoid cells

(2013) Paula Licona-Limón et al.   NATURE IMMUNOLOGY

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

(2013) Ansuman T Satpathy et al.   NATURE IMMUNOLOGY

Differential response of BDCA-1+ and BDCA-3+ myeloid dendritic cells to respiratory syncytial virus infection

(2013) Meera R Gupta et al.   RESPIRATORY RESEARCH

The CD4-centered universe of human T cell subsets

(2013) J. Geginat et al.   SEMINARS IN IMMUNOLOGY

DNA vaccines

(2013) Cevayir Coban et al.   Human Vaccines & Immunotherapeutics

Plasmacytoid Dendritic Cells Contribute to Systemic but Not Local Antiviral Responses to HSV Infections

(2013) Melissa Swiecki et al.   PLoS Pathogens

Human plasmacytoid dendritic cells efficiently cross-present exogenous Ags to CD8+ T cells despite lower Ag uptake than myeloid dendritic cell subsets

(2012) J. Tel et al.   BLOOD

HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells

(2012) J. Florentin et al.   BLOOD

DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues

(2012) L. F. Poulin et al.   BLOOD

Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli

(2012) Andrew J. Kassianos et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans

(2012) Horst von Bernuth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Type 2 Myeloid Dendritic Cells Produce Interferon-λ and Amplify Interferon-α in Response to Hepatitis C Virus Infection

(2012) Shuye Zhang et al.   GASTROENTEROLOGY

Human blood dendritic cell antigen 3 (BDCA3)+dendritic cells are a potent producer of interferon-λ in response to hepatitis C virus

(2012) Sachiyo Yoshio et al.   HEPATOLOGY

Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

(2012) Muzlifah Haniffa et al.   IMMUNITY

Characterization of resident and migratory dendritic cells in human lymph nodes

(2012) Elodie Segura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasmacytoid Dendritic Cells: Recent Progress and Open Questions

(2011) Boris Reizis et al.   Annual Review of Immunology

Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner

(2011) Samuel Huber et al.   IMMUNITY

An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells

(2011) Weiguo Cui et al.   IMMUNITY

Myeloid C-type Lectin Receptors in Pathogen Recognition and Host Defense

(2011) Fabiola Osorio et al.   IMMUNITY

Human Dendritic Cell Subsets from Spleen and Blood Are Similar in Phenotype and Function but Modified by Donor Health Status

(2011) D. Mittag et al.   JOURNAL OF IMMUNOLOGY

IFN-  and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells

(2011) H. Le Buanec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-lambda and therapy for chronic hepatitis C virus infection

(2011) Raymond P. Donnelly et al.   TRENDS IN IMMUNOLOGY

The form of NY-ESO-1 antigen has an impact on the clinical efficacy of anti-tumor vaccination

(2011) Iana Parvanova et al.   VACCINE

IL-4 enhances IFN- 1 (IL-29) production by plasmacytoid DCs via monocyte secretion of IL-1Ra

(2010) N. J. Megjugorac et al.   BLOOD

Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway

(2010) S. Gregori et al.   BLOOD

Intranodal Vaccination with Naked Antigen-Encoding RNA Elicits Potent Prophylactic and Therapeutic Antitumoral Immunity

(2010) S. Kreiter et al.   CANCER RESEARCH

Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas

(2010) Cheolho Cheong et al.   CELL

Biology of interleukin-10

(2010) Robert Sabat et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The CD8+dendritic cell subset

(2010) Ken Shortman et al.   IMMUNOLOGICAL REVIEWS

The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8α+dendritic cells

(2010) Karine Crozat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+cells as homologues of mouse CD8+dendritic cells

(2010) Annabell Bachem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peripheral CD103+dendritic cells form a unified subset developmentally related to CD8α+conventional dendritic cells

(2010) Brian T. Edelson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mouse CD8α+DCs and human BDCA3+DCs are major producers of IFN-λ in response to poly IC

(2010) Henning Lauterbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Found in translation: the human equivalent of mouse CD8+dendritic cells: Table I.

(2010) Jose A. Villadangos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Intestinal Lamina Propria CD1c+ Dendritic Cells Display an Activated Phenotype at Steady State and Produce IL-23 in Response to TLR7/8 Stimulation

(2010) S. M. Dillon et al.   JOURNAL OF IMMUNOLOGY

Intradermal Vaccinations With RNA Coding for TAA Generate CD8+ and CD4+ Immune Responses and Induce Clinical Benefit in Vaccinated Patients

(2010) Susanne M Rittig et al.   MOLECULAR THERAPY

Harnessing Dendritic Cells to Generate Cancer Vaccines

(2009) Karolina Palucka et al.   Annals of the New York Academy of Sciences

Selective Expression of the Chemokine Receptor XCR1 on Cross-presenting Dendritic Cells Determines Cooperation with CD8+ T Cells

(2009) Brigitte G. Dorner et al.   IMMUNITY

IL-10 and IL-27 producing dendritic cells capable of enhancing IL-10 production of T cells are induced in oral tolerance

(2009) Aya Shiokawa et al.   IMMUNOLOGY LETTERS

Dendritic cells in intestinal homeostasis and disease

(2009) Maria Rescigno et al.   JOURNAL OF CLINICAL INVESTIGATION

CD207+CD103+dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells

(2009) Sandrine Henri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification and characterization of IL-10/IFN-γ–producing effector-like T cells with regulatory function in human blood

(2009) Barbara Häringer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Plasmacytoid Dendritic Cells Induce IL-10 Production in T Cells via the Delta-Like-4/Notch Axis

(2009) N. Kassner et al.   JOURNAL OF IMMUNOLOGY

IL-27 Is a Key Regulator of IL-10 and IL-17 Production by Human CD4+ T Cells

(2009) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses

(2009) Hideki Nakano et al.   NATURE IMMUNOLOGY

In Vivo Analysis of Dendritic Cell Development and Homeostasis

(2009) K. Liu et al.   SCIENCE

Developmental regulation of MHC II expression and transport in human plasmacytoid-derived dendritic cells

(2008) C. Sadaka et al.   BLOOD

Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation

(2008) J. Mouries et al.   BLOOD

Induction, function and regulation of IL-17-producing T cells

(2008) Kingston H. G. Mills   EUROPEAN JOURNAL OF IMMUNOLOGY

Antigen-Presentation Properties of Plasmacytoid Dendritic Cells

(2008) José A. Villadangos et al.   IMMUNITY

Deficiency of Th17 cells in hyper IgE syndrome due to mutations inSTAT3

(2008) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

(2008) Mirjam Kool et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA

(2008) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE

Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS21 induce strong and persistent humoral and T cell responses against hepatitis B surface antigen in healthy adult volunteers

(2008) Pierre Vandepapelière et al.   VACCINE

Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9

(2007) Stefan Bauer et al.   IMMUNOBIOLOGY