CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection

Belatacept and Long-Term Outcomes in Kidney Transplantation

(2016) Flavio Vincenti et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-2 and IL-15 regulate CD8+memory T-cell differentiation but are dispensable for protective recall responses

(2015) Cédric Mathieu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammatory IL-15 is required for optimal memory T cell responses

(2015) Martin J. Richer et al.   JOURNAL OF CLINICAL INVESTIGATION

The viral context instructs the redundancy of costimulatory pathways in driving CD8+ T cell expansion

(2015) Suzanne PM Welten et al.   eLife

IL-15 Induces Alloreactive CD28−Memory CD8 T Cell Proliferation and CTLA4-Ig Resistant Memory CD8 T Cell Activation

(2014) O. Traitanon et al.   AMERICAN JOURNAL OF TRANSPLANTATION

IL-15 Serves as a Costimulator in Determining the Activity of Autoreactive CD8 T Cells in an Experimental Mouse Model of Graft-versus-Host-Like Disease

(2014) F. Miyagawa et al.   JOURNAL OF IMMUNOLOGY

CD40 on APCs Is Needed for Optimal Programming, Maintenance, and Recall of CD8+ T Cell Memory Even in the Absence of CD4+ T Cell Help

(2014) M. G. H. Hernandez et al.   JOURNAL OF IMMUNOLOGY

Control of Memory CD8+ T Cell Differentiation by CD80/CD86-CD28 Costimulation and Restoration by IL-2 during the Recall Response

(2014) S. Fuse et al.   JOURNAL OF IMMUNOLOGY

Natural CD8+CD122+ T Cells Are More Potent in Suppression of Allograft Rejection Than CD4+CD25+ Regulatory T Cells

(2013) Z. Dai et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Long-Term Belatacept Exposure Maintains Efficacy and Safety at 5 Years: Results From the Long-Term Extension of the BENEFIT Study

(2013) L. Rostaing et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The who's who of T-cell differentiation: Human memory T-cell subsets

(2013) Yolanda D. Mahnke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Superior T memory stem cell persistence supports long-lived T cell memory

(2013) Enrico Lugli et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin-dependent diabetes induced by pancreatic beta cell expression of IL-15 and IL-15R 

(2013) J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors

(2012) N. Cieri et al.   BLOOD

Transient Enhanced IL-2R Signaling Early during Priming Rapidly Amplifies Development of Functional CD8 + T Effector-Memory Cells

(2012) Iris Castro et al.   JOURNAL OF IMMUNOLOGY

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

(2012) Aaron M Ring et al.   NATURE IMMUNOLOGY

IL-2 and IL-15 signaling complexes: different but the same

(2012) Shinji Ikemizu et al.   NATURE IMMUNOLOGY

Interleukin-15 Plays a Central Role in Human Kidney Physiology and Cancer through the γc Signaling Pathway

(2012) Julien Giron-Michel et al.   PLoS One

IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood

(2011) M. C. Sneller et al.   BLOOD

Limiting the Amount and Duration of Antigen Exposure during Priming Increases Memory T Cell Requirement for Costimulation during Recall

(2011) T. L. Floyd et al.   JOURNAL OF IMMUNOLOGY

The Basis of Distinctive IL-2– and IL-15–Dependent Signaling: Weak CD122-Dependent Signaling Favors CD8 + T Central-Memory Cell Survival but Not T Effector-Memory Cell Development

(2011) Iris Castro et al.   JOURNAL OF IMMUNOLOGY

Transplantation Tolerance: Memories That Haunt Us

(2011) M. L. Ford et al.   Science Translational Medicine

Belatacept-Based Regimens Are Associated With Improved Cardiovascular and Metabolic Risk Factors Compared With Cyclosporine in Kidney Transplant Recipients (BENEFIT and BENEFIT-EXT Studies)

(2011) Yves Vanrenterghem et al.   TRANSPLANTATION

Belatacept: The Promises and Challenges of Belatacept and Costimulatory Blockade

(2010) B. Kaplan   AMERICAN JOURNAL OF TRANSPLANTATION

A Phase III Study of Belatacept-based Immunosuppression Regimens versus Cyclosporine in Renal Transplant Recipients (BENEFIT Study)

(2010) F. Vincenti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Long-Term Renal Allograft Survival in the United States: A Critical Reappraisal

(2010) K. E. Lamb et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo

(2010) Vandana Kalia et al.   IMMUNITY

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

(2010) Matthew E. Pipkin et al.   IMMUNITY

Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

(2010) Thomas R. Malek et al.   IMMUNITY

Cutting Edge: Programmed Death-1 Defines CD8+CD122+ T Cells as Regulatory versus Memory T Cells

(2010) H. Dai et al.   JOURNAL OF IMMUNOLOGY

Distinct Roles for IL-2 and IL-15 in the Differentiation and Survival of CD8+ Effector and Memory T Cells

(2010) D. M. Mitchell et al.   JOURNAL OF IMMUNOLOGY

IL-15 Regulates Both Quantitative and Qualitative Features of the Memory CD8 T Cell Pool

(2009) Michelle M. Sandau et al.   JOURNAL OF IMMUNOLOGY

CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses

(2009) J. J. Obar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes

(2009) S. Yokoyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Effect of Costimulatory and Interleukin 2 Receptor Blockade on Regulatory T Cells in Renal Transplantation

(2008) J. A. Bluestone et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Phenotype and function of human T lymphocyte subsets: Consensus and issues

(2008) Victor Appay et al.   CYTOMETRY PART A

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY