Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: Application of physiologically-based pharmacokinetic modeling to gain quantitative insights

Application of a physiologically-based pharmacokinetic model for the prediction of bumetanide plasma and brain concentrations in the neonate

(2018) Maria D. Donovan et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats

(2018) Priyanka Arora et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Impact of capillary flow hydrodynamics on carrier-mediated transport of opioid derivatives at the blood-brain barrier, based on pH -dependent Michaelis-Menten and Crone-Renkin analyses

(2017) Siti R. Yusof et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells

(2017) Amanda Tivnan et al.   Oncotarget

Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data

(2016) Lu Gaohua et al.   Drug Metabolism and Pharmacokinetics

PBPK modeling and simulation in drug research and development

(2016) Xiaomei Zhuang et al.   Acta Pharmaceutica Sinica B

Predicting the Effect of CYP3A Inducers on the Pharmacokinetics of Substrate Drugs Using Physiologically Based Pharmacokinetic (PBPK) Modeling: An Analysis of PBPK Submissions to the US FDA

(2015) Christian Wagner et al.   CLINICAL PHARMACOKINETICS

Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

(2015) HM Jones et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Nonsurgical treatment of recurrent glioblastoma

(2015) O. Gallego   Current Oncology

Preclinical Pharmacological Evaluation of Letrozole as a Novel Treatment for Gliomas

(2015) N. Dave et al.   MOLECULAR CANCER THERAPEUTICS

Aromatase and estrogen receptor alpha mRNA expression as prognostic biomarkers in patients with astrocytomas

(2014) J. M. Dueñas Jiménez et al.   JOURNAL OF NEURO-ONCOLOGY

High CYP2A6 Enzyme Activity as Measured by a Caffeine Test and Unique Distribution of CYP2A6 Variant Alleles in Ethiopian Population

(2014) Eleni Aklillu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Development of a Physiologically-Based Pharmacokinetic Model of the Rat Central Nervous System

(2014) Raj Badhan et al.   Pharmaceutics

The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis

(2013) Nimita Dave et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Postoperative treatment of glioblastoma multiforme with radiation therapy plus concomitant and adjuvant temozolomide : A mono-institutional experience of 215 patients

(2013) DayaNand Sharma et al.   Journal of Cancer Research and Therapeutics

Health-related quality of life and cognitive functioning in long-term anaplastic oligodendroglioma and oligoastrocytoma survivors

(2013) Esther J. J. Habets et al.   JOURNAL OF NEURO-ONCOLOGY

Investigation of the effect of active efflux at the blood–brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system

(2013) Mari Miyajima et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Development of a Physiologically Based Pharmacokinetic Model for the Rat Central Nervous System and Determination of an In Vitro–In Vivo Scaling Methodology for the Blood–Brain Barrier Permeability of Two Transporter Substrates, Morphine and Oxycodone

(2012) Kathryn Ball et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A New In Situ Brain Perfusion Flow Correction Method for Lipophilic Drugs Based on the pH-Dependent Crone-Renkin Equation

(2010) Alex Avdeef et al.   PHARMACEUTICAL RESEARCH

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

(2009) K. Murai et al.   XENOBIOTICA

Unbound Drug Concentration in Brain Homogenate and Cerebral Spinal Fluid at Steady State as a Surrogate for Unbound Concentration in Brain Interstitial Fluid

(2008) X. Liu et al.   DRUG METABOLISM AND DISPOSITION